Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: Partial restoration of some parameters to control levels

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 2, 2008, Pages 153-161

  Choi, Young H ^a   Lee, Inchul ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYTOCHROME P450 2C11; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PROTEIN CALORIE MALNUTRITION; PROTEIN DIET; PROTEIN EXPRESSION; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; CYSTEINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAVENOUS; MALE; MEMBRANE PROTEINS; METFORMIN; NUTRITIONAL STATUS; PROTEIN-ENERGY MALNUTRITION; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE;

EID: 38949162555     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.2.0003     Document Type: Article

References (31)

1. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
2. Buchanan, N. (1978) Drug kinetics in protein energy malnutrition. S. Afr. Med. J. 53: 327-330
3. Chiou, W. L. (1978) Critical evaluation of the potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J. Pharmacokinet. Biopharm. 6: 539-546
4. Cho, M. K., Kim, Y. G., Lee, M. G., Kim, S. G. (1999) Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Arch. Biochem. Biophys. 372: 150-158
5. Choi, Y. H., Lee, M. G. (2006) Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1, and 3A21/2 for the metabolism of metformin. Br. J. Pharmacol. 149: 424-430
6. Choi, Y. H., Kim, S. G., Lee, M. G. (2006) Dose-independent pharmacokinetics of metformin after intravenous and oral administration in rats: hepatic and gastrointestinal first-pass effects. J. Pharm. Sci. 95: 2543-2552
7. Denke, M., Wilson, J. D. (1998) Protein and energy malnutrition. In: Fauci, A. S., Braunwald, E., Isselbacher, K. J., Wilson, J. D., Martin, J. B., Kasper, D. L., Hauser, S. L., Longo, D. L. (eds) Principles of internal medicine. 14th edn, McGraw-Hill, New York, pp 452-454
8. Duggleby, R. G. (1995) Analysis of enzyme progress curves by nonlinear regression. Methods Enzymol. 249: 61-90
9. Gibaldi, M., Perrier, D. (1982) Pharmacokinetics. 2nd edn, Marcel-Dekker, New York.
10. Hale, T. W., Kristensen, J. H., Hackett, L. P., Kohan, R., Ilett, K. F. (2002) Transfer of metformin into human milk. Diabetologia 45: 1509-1514
11. Kaminsky, L. S., Fasco, M. J. (1991) Small intestinal cytochromes P450. Crit. Rev. Toxicol. 21: 407-422
12. Kaminsky, L. S., Zhang, Q.-Y. (2003) The small intestine as a xenobiotic-metabolizing organ. Drug Metab. Dispos. 31: 1520-1525
13. Khaled, M. A. (1994) Oxidative stress in childhood malnutrition and diarrhea diseases. J. Diarrhoeal Dis. Res. 12: 165-172
14. Kim, S. H., Choi, Y. M., Lee, M. G. (1993) Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J. Pharmacokinet. Biopharm. 21: 1-17
15. Kim, Y. G., Kim, S. K., Kwon, J. W., Park, O. J., Kim, S. G., Kim, Y. C., Lee, M. G. (2003) Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition. Life Sci. 72: 1171-1181
16. Krishnaswamy, K. (1978) Drug metabolism and pharmacokinetics in malnutrition. Clin. Pharmacokinet. 3: 216-240
17. Lee, M. G., Chiou, W. L. (1983) Evaluation of potential causes for the incomplete bioavailability of furosemide: gastric first-pass metabolism. J. Pharmacokinet. Biopharm. 11: 623-660
18. Lee, J. H., Suh, O. K., Lee, M. G. (2004) Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes. Arch. Pharm. Res. 27: 693-712
19. Lee, D. Y., Lee, I., Lee, M. G. (2007) Effects of cysteine on the pharmacokinetic parameters of omeprazole in rats with protein-calorie malnutrition: Partial restoration of some parameters to control levels by oral cysteine supplementation. J. Parent. Ent. Nutr. 31: 37-46
20. Martignoni, M., Groothuis, G., de Kanter, R. (2006) Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine. Drug Metab. Dispos. 34: 1047-1054
21. Mitruka, B. M., Rawnsley, H. M. (1981) Clinical biochemical and hematological reference values in normal experimental animals and normal humans. 2nd edn, Masson Publishing USA Inc., New York
22. Miura, K., Ishii, T., Sugita, Y., Bannai, S., Miura, K., Ishii, T., Sugira, Y., Bannai, S. (1992) Cysteine uptake and glutathione level in endothelial cells exposed to oxidative stress. Am. J. Phys. 62: C50-C58
23. Morley, J. E., Perry, H. M. (1991) The management of diabetes mellitus in older individuals. Drugs 41: 548-565
24. Pahan, K., Smith, B. T., Singh, A. K., Singh, I. (1997) Cytochrome P450 2E1 in rat liver peroxisomes: downregulation by ishchemia/reperfusion-induced oxidative stress. Free Radic. Biol. Med. 23: 963-971
25. Scheen, A.J. (1996) Clinical pharmacokinetics of metformin. Clin. Pharmacokinet. 30: 359-371
26. Sirtori, C. R., Franceschini, G., Galli-Kienle, M., Cighetti, G., Galli, G., Bondioli, A., Conti, F. (1978) Disposition of metformin (N,N- dimethylbiguanide) in man. Clin. Pharmacol. Ther. 24: 683-693
27. Sodhi, C. P., Rana, S. F., Attri, S., Mehta, S., Yaiphei, K., Mehta, S. K. (1998) Oxidative-hepatic injury of isoniazid-rifampicin in young rats subjected to protein and energy malnutrition. Drug Chem. Toxicol. 21: 305-317
28. Stipanuk, M. H., Coloso, R. M., Garci, R. A., Banks, M. F. (1992) Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. J. Nutr. 122: 420-427
29. Tucker, G. T., Casey, C., Phillips, P. J., Connor, H., Ward, J. D., Woods, H. F. (1981) Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br. J. Clin. Pharmacol. 12: 235-246
30. Turnbull, P. J., Sinclair, A. J. (2002) Evaluation of nutritional status and its relationship with functional status in older citizens with diabetes mellitus using the mini nutritional assessment (MNA) tool: a preliminary investigation. J. Nutr. Health Aging 6: 185-189
31. Wilkinson, G. R., Shand, D. G. (1975) A physiological approach to hepatic drug clearance. Clin. Pharmacol. Ther. 18: 377-390