Effects of cysteine on the pharmacokinetic parameters of omeprazole in rats with protein-calorie malnutrition: Partial restoration of some parameters to control levels by oral cysteine supplementation

Journal of Parenteral and Enteral Nutrition

Volumn 31, Issue 1, 2007, Pages 37-46

  Lee, Dae Y ^a   Lee, Inchul ^b   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2D1; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; OMEPRAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG CLEARANCE; ENZYME ANALYSIS; IN VITRO STUDY; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CALORIE MALNUTRITION; PROTEIN EXPRESSION; RAT; STOMACH SECRETION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; INJECTIONS, INTRAVENOUS; LIVER; MALE; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; OMEPRAZOLE; PROTEIN-ENERGY MALNUTRITION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 33845948270     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/014860710703100137     Document Type: Article

References (47)

1. Denke M, Wilson JD. Protein and energy malnutrition. In: Fauci AS, Braunwald E, Isselbacher KJ, et al, eds. Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill; 1998:452-454.
2. Buchanan N. Drug kinetics in protein energy malnutrition. S Afr Med J. 1978;53:327-330.
3. Krishnaswamy K. Drug metabolism and pharmacokinetics in malnutrition. Clin Pharmacokinet. 1978;3:216-240.
4. Lee JH, Suh OK, Lee MG. Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes. Arch Pharm Res. 2004;27:693-712.
5. Cho MK, Kim YG, Lee MG, Kim SG. Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. Arch Biochem Biophys. 1999;372:150-158.
6. Im W, Blakeman DP, Davis JP. Irreversible inactivation of rat gastric (H+-K+)-ATPase in vivo by omeprazole. Biochem Biophys Res Commun. 1985;126:78-82.
7. Lee DY, Shin HS, Bae SK, Lee MG. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats. Biopharm Drug Dispos. 2006;27:209-218.
8. Paula AC, Gracioso JS, Toma W, et al. Is gastric ulceration different in normal and malnourished rats? Br J Nutr. 2005;93:47-52.
9. Kawai T, Teshima S, Kusumoto K, et al. A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats. J Lab Clin Med. 2000;136:138-148.
10. Sezer S, Ibis A, Ozdemir BH, et al. Association of Helicobacter pylori infection with nutritional status in hemodialysis patients. Transplant Proc. 2004;36:47-49.
11. Borras-Blasco J, Navarro-Ruiz A, Navarro-Blasco F, Tovar-Beltran J, Gonzalez-Delgado M. Erythrodermia induced by omeprazole. Int J Clin Pharmacol Ther. 2001;39:219-223.
12. Lutz M, Schwab M, Griese EU, et al. Visual disorders associated with omeprazole and their relation to CYP2C19 polymorphism. Pharmacogenetics. 2002;12:73-75.
13. Bae SK, Yang SH, Kim JW, Kim T, Kwon JW, Lee MG. Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition. J Pharm Sci. 2005;94:1484-1493.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
15. Kang WK, Kim DS, Kwon KI. Advanced method for determination of omeprazole in plasma by HPLC. Arch Pharm Res. 1999;22:86-88.
16. Duggleby RG. Analysis of enzyme progress curves by nonlinear regression. Methods Enzymol. 1995;249:61-90.
17. Shim HJ, Lee EJ, Kim SH, et al. Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique. Biopharm Drug Dispos. 2000;21:285-291.
18. Kim SH, Choi YM, Lee MG. Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J Pharmacokinet Biopharm. 1993;21:1-17.
19. Watanabe K, Matsuka N, Okazaki M, Hashimoto Y, Araki H, Gomita Y. The effect of immobilization stress on the pharmacokinetics of omeprazole in rats. Acta Med Okayama. 2002;56:19-23.
20. Chiou WL. Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm. 1978;6:539-549.
21. Gibaldi M, Ferner D. Pharmacokinetics. 2nd ed. New York, NY: Marcel-Dekker, Inc; 1982.
22. Chiou WL. New calculation method of mean apparent drug volume of distribution and application to rational dosage regimen. J Pharm Sci. 1979;68:1067-1069.
23. Eatman FB, Colburn WA, Boxenbaum HG, et al. Pharmacokinetics of diazepam following multiple dose oral administration to healthy human subjects. J Pharmacokinet Biopharm. 1977;5:481-494.
24. Chiou WL. New calculation method of mean total body clearance of drugs and its application to rational dosage regimens. J Pharm Sci. 1980;69:90-91.
25. Mitruka BM, Rawnsley HM. Clinical, Biochemical and Hematological Reference Values in Normal Experimental Animals and Normal Humans. 2nd ed. New York, NY: Masson Publishing Inc; 1981:163.
26. Obama M, Cangir A, van Eys J. Nutritional status and anthracycline cardiotoxicity in children. South Med J. 1983;76:577-578.
27. Gamelli RL, Foster RS Jr. Effects of protein-calorie malnutrition and refeeding on fluorouracil toxicity. Arch Surg. 1983;118:1182-1185.
28. Brennan MF. Uncomplicated starvation versus cancer cachexia. Cancer Res. 1977;37:2359-2364.
29. Costa G. Cachexia, the metabolic component of neoplastic diseases. Cancer Res. 1977;37:2327-2335.
30. Watanabe K, Furuno K, Eto K, Oishi R, Gomita Y. First-pass metabolism of omeprazole in rats. J Pharm Sci. 1994;83:1131-1134.
31. Webster LK, Jones DB, Mihaly GW, Morgan DJ, Smallwood RA. Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver. Biochem Pharmacol. 1985;34:1239-1245.
32. Karam WG, Goldstein JA, Lasker JM, Ghanayem BI. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996;24:1081-1087.
33. Wilkinson GR, Shand DG. A physiological approach to hepatic drug clearance. Clin Pharmacol Ther. 1975;18:377-390.
34. Remesy C, Demigne C. Changes in availability of glucogenic and ketogenic substrates and liver metabolism in fed or starved rats. Ann Nutr Metab. 1983;27:57-70.
35. Laperche Y, Preaux AM, Feldmann G, Mahu JL, Berthelot P. Effect of fasting on organic anion uptake by isolated rat liver cells. Hepatology. 1981;1:617-621.
36. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF Jr. Liver and kidney metabolism during prolonged starvation. J Clin Invest. 1969;48:574-583.
37. Zaramella MG, Vallini R, Tiribelli C. Estimation of the hepatic blood "flow" by galactose plasma clearance in patients with liver disease. Liver. 1985;5:129-133.
38. Khaled MA. Oxidative stress in childhood malnutrition and diarrhoeal diseases. J Diarrhoeal Dis Res. 1994;12:165-172.
39. Sodhi CP, Rana SF, Attri S, Mehta S, Yaiphei K, Mehta SK. Oxidative-hepatic injury of isoniazid-rifampicin in young rats subjected to protein and energy malnutrition. Drug Chem Toxicol. 1998;21:305-317.
40. Pahan K, Smith BT, Singh AK, Singh I. Cytochrome P-450 2E1 in rat liver peroxisomes: Downregulation by ischemia/reperfusion-induced oxidative stress. Free Radic Biol Med. 1997;23:963-971.
41. Stipanuk MH, Coloso RM, Garcia RA, Banks MF. Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. J Nutr. 1992;122:420-427.
42. Miura K, Ishii T, Sugita Y, et al. Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress. Am J Physiol. 1992;262:C50-C58.
43. Kim YG, Kim SK, Kwon JW, et al. Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition. Life Sci. 2003;72:1171-1181.
44. Kim YG, Cho MK, Kwon JW, Kim SG, Kim SH, Lee MG. Effects of cysteine on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats with protein-calorie malnutrition. Life Sci. 2001;68:2329-2345.
45. Regardh CG, Gabrielsson M, Hoffman KJ, Lofberg I, Skanberg I. Pharmacokinetics and metabolism of omeprazole in animals and man: an overview. Scand J Gastroenterol. 1985;108(suppl):79-94.
46. Hakkak R, Ronis MJ, Badger TM. Effects of enteral nutrition and ethanol on cytochrome P450 distribution in small intestine of male rats. Gastroenterology. 1993;104:1611-1618.
47. Kaminsky LS, Fasco MJ. Small intestinal cytochromes P450. Crit Rev Toxicol. 1991;21:407-422.