CNTF Negatively regulates the phototransduction machinery in rod photoreceptors: Implication for light-induced photostasis plasticity

Advances in Experimental Medicine and Biology

Volumn 613, Issue , 2008, Pages 407-413

  Wen, Rong ^a   Song, Ying ^b   Liu, Yun ^b   Li, Yiwen ^b   Zhao, Lian ^b   Laties, Alan M ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; RETINA S ANTIGEN; RHODOPSIN; MESSENGER RNA; RECOMBINANT PROTEIN; TRANSDUCIN;

CONFERENCE PAPER; ELECTRORETINOGRAM; NERVE CELL PLASTICITY; NONHUMAN; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CYTOLOGY; DARK ADAPTATION; ELECTRORETINOGRAPHY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INJECTION; LIGHT; LONG EVANS RAT; METABOLISM; PHYSIOLOGY; RAT; RETINA ROD; RETINA ROD OUTER SEGMENT; TIME; VITREOUS BODY;

ANIMALS; ARRESTIN; CILIARY NEUROTROPHIC FACTOR; DARK ADAPTATION; ELECTRORETINOGRAPHY; GENE EXPRESSION REGULATION; HUMANS; INJECTIONS; LIGHT; MODELS, BIOLOGICAL; PHOTOTRANSDUCTION; RATS; RATS, LONG-EVANS; RECOMBINANT PROTEINS; RHODOPSIN; RNA, MESSENGER; ROD OUTER SEGMENTS; RODS (RETINA); TIME FACTORS; TRANSDUCIN; VITREOUS BODY;

EID: 38949098237     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-74904-4_48     Document Type: Conference Paper

References (19)

1. Bargoot, F. G.,Williams, T. P. and Beidler, L. M., 1969, The localization of radioactive amino acid taken up into the outer segments of frog (Rana pipiens) rods. Vision Res 9:385-391.
2. Battelle, B. A. and LaVail, M. M., 1978, Rhodopsin content and rod outer segment length in albino rat eyes: modification by dark adaptation. Exp Eye Res 26:487-497.
3. Berson, D. M., Dunn, F. A. and Takao, M., 2002, Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070-1073.
4. Bok, D., Yasumura, D., Matthes, M. T., Ruiz, A., Duncan, J. L., Chappelow, A. V., Zolutukhin, S., Hauswirth,W. and LaVail, M. M., 2002, Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 74:719-735.
5. Farber, D. B., Danciger, J. S. and Organisciak, D. T., 1991, Levels of mRNA encoding proteins of the cGMP cascade as a function of light environment. Exp Eye Res 53:781-786.
6. Fulton, A. B. and Rushton, W. A., 1978, The human rod ERG: correlation with psychophysical responses in light and dark adaptation. Vision Res 18:793-800.
7. Hall, M. O., Bok, D. and Bacharach, A. D., 1969, Biosynthesis and assembly of the rod outer segment membrane system. Formation and fate of visual pigment in the frog retina. J Mol Biol 45:397-406.
8. LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D. and Steinberg, R. H., 1992, Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A 89:11249-11253.
9. Liang, F. Q., Aleman, T. S., Dejneka, N. S., Dudus, L., Fisher, K. J., Maguire, A. M., Jacobson, S. G. and Bennett, J., 2001, Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther 4:461-472.
10. Organisciak, D. T. and Noell, W. K., 1977, The rod outer segment phospholipid/opsin ratio of rats maintained in darkness or cyclic light. Invest Ophthalmol Vis Sci 16:188-190.
11. Organisciak, D. T., Xie, A., Wang, H. M., Jiang, Y. L., Darrow, R. M. and Donoso, L. A., 1991, Adaptive changes in visual cell transduction protein levels: effect of light. Exp Eye Res 53: 773-779.
12. Penn, J. S. and Williams, T. P., 1986, Photostasis: regulation of daily photon-catch by rat retinas in response to various cyclic illuminances. Exp Eye Res 43:915-928.
13. Peterson, W. M., Wang, Q., Tzekova, R. and Wiegand, S. J., 2000, Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 20: 4081-4090.
14. Reiser,M. A.,Williams, T. P. and Pugh, E. N., Jr., 1996, The effect of light history on the aspartateisolated fast-PIII responses of the albino rat retina. Invest Ophthalmol Vis Sci 37:221-229.
15. Schlichtenbrede, F. C., MacNeil, A., Bainbridge, J. W., Tschernutter, M., Thrasher, A. J., Smith, A. J. and Ali, R. R., 2003, Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration. Gene Ther 10:523-527.
16. Wen, R., Song, Y., Kjellstrom, S., Tanikawa, A., Liu, Y., Li, Y., Zhao, L., Bush, R. A., Laties, A. M. and Sieving, P. A., 2006, Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26:13523-13530.
17. Young, R. W., 1967, The renewal of photoreceptor cell outer segments. J Cell Biol 33:61-72.
18. Young, R. W. and Droz, B., 1968, The renewal of protein in retinal rods and cones. J Cell Biol 39:169-184.
19. Young, R. W. and Bok, D., 1969, Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol 42:392-403.