Two-minute skin anesthesia through ultrasound pretreatment and iontophoretic delivery of a topical anesthetic: A feasibility study

Pain Medicine

Volumn 9, Issue 1, 2008, Pages 55-59

  Spierings, Egilius L H ^a,c   Brevard, Julie A ^b   Katz, Nathaniel P ^b  

^a MedVadis Research Corporation   (United States)

^b INFLEXXION INC   (United States)

^c NONE   (United States)

Author keywords

Iontophoresis; Lidocaine; Needle pain; SonoPrep ; Topical anesthesia; Ultrasound

Indexed keywords

ADRENALIN; ANESTHETIC AGENT; IONTOCAINE; LIDOCAINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; ELECTRIC POTENTIAL; ERYTHEMA; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; IONTOPHORESIS; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PREMEDICATION; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SINGLE BLIND PROCEDURE; SKIN CONDUCTANCE; SKIN PAIN; SKIN PERMEABILITY; SKIN REDNESS; TOPICAL ANESTHESIA; TREATMENT DURATION; ULTRASOUND; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; AGED; ANESTHETICS, LOCAL; CROSS-OVER STUDIES; EPINEPHRINE; FEMALE; HUMANS; INJECTIONS; IONTOPHORESIS; LIDOCAINE; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; SINGLE-BLIND METHOD; SKIN; ULTRASONIC THERAPY; VASOCONSTRICTOR AGENTS;

EID: 38949084574     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2007.00281.x     Document Type: Article

References (16)

1. Cummings EA, Reid GJ, Finley GA, et al. Prevalence and source of pain in pediatric inpatients. Pain 1996; 68: 25-31.
2. Pitetti RD. Do no harm-But first, do no hurt. CMAJ 2005; 172: 1699.
3. Taddio A, Kaur Soin H, Schuh S, et al. Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: A randomized controlled trial. CMAJ 2005; 172: 1691-5.
4. Kleiber C, Sorenson M, Whiteside K, et al. Topical anesthetics for intravenous insertion in children: A randomized equivalency study. Pediatrics 2002; 110: 758-61.
5. Eichenfield LF, Funk A, Fallon-Friedlander S, Cunningham BB. A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. Pediatrics 2002; 109: 1093-9.
6. Zempsky WT, Anand KJS, Sullivan KM, et al. Lidocaine iontophoresis for topical anesthesia before intravenous line placement in children. J Pediatr 1998; 132: 1061-3.
7. Kim MK, Kini NM, Trshynski TJ, Hennes HM. A randomized clinical trial of dermal anesthesia by iontophoresis for peripheral intravenous catheter placement in children. Ann Emerg Med 1999; 33: 359.
8. Zeltzer L, Regaldo M, Nichter L, et al. Iontophoresis versus subcutaneous injection: A comparison of two methods of local anesthesia delivery in children. Pain 1991; 44: 73-8.
9. Katz NP, Shapiro DE, Herrmann TE, et al. Rapid onset of cutaneous anesthesia with EMLA cream after pretreatment with a new ultrasound-emitting device. Anesth Analg 2004; 98: 371-6.
10. Becker BM, Helfrich S, Baker E, et al. Ultrasound with topical anesthetic rapidly decreases pain of intravenous sticks. Acad Emerg Med 2005; 12: 289-95.
11. Mitragotri S, Kost J. Low-frequency sonophoresis: A review. Adv Drug Deliv Rev 2004; 56: 589-601.
12. Mitragotri S, Kost J. Low-frequency sonophoresis: A non-invasive method of drug delivery and diagnosis. Biotechnol Prog 2000; 16: 488-92.
13. Tezel A, Sens A, Tuchscherer J, Mitragotri S. Synergistic effect of low-frequency ultrasound and surfactants on skin permeability. J Pharm Sci 2002; 91: 91-100.
14. Farinha A, Kellogg S, Dickinson K, Davidson T. Skin impedance reduction for electrophysiology measurements using ultrasonic skin permeation: Initial report and comparison to current methods. Biomed Instrum Technol 2006; 40: 72-7.
15. Bezzant JL, Stephen RL, Petelenz TJ, Jacobson SC. Painless cauterization of spider veins with the use of iontophoretic local anesthesia. J Am Acad Dermatol 1988; 19: 869-75.
16. Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics 2004; 114: 1348-56.