Genetic alterations of the Cdx2 gene in gastric cancer

APMIS

Volumn 116, Issue 1, 2008, Pages 74-80

  Song, Jae Hwi ^a   Kim, Chang Jae ^a   Cho, Yong Gu ^a   Chae, Hiun Suk ^a   Cao, Zhang ^a   Nam, Suk Woo ^a   Lee, Jung Young ^a   Park, Won Sang ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Homeobox gene; Loss of heterozygosity; Somatic mutation; Stomach cancer

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CANCER CELL; CDX2 GENE; CODON; CONTROLLED STUDY; EXON; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE METAPLASIA; MALE; MISSENSE MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; STAINING; STOMACH CANCER; STOMACH MUCOSA;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CARCINOMA; FEMALE; GASTRIC MUCOSA; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; STOMACH; STOMACH NEOPLASMS;

EID: 38849207669     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2008.00881.x     Document Type: Article

References (26)

1. Shin HR, Jung KW, Won YJ, Park JG. 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals. J Korean Cancer Assoc 2004 36 : 103 14.
2. Yuasa Y. Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 2003 3 : 592 600.
3. Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000 119 : 961 71.
4. Eda A, Osawa H, Yanaka I, Satoh K, Mutoh H, Kihira K, et al. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 2002 37 : 94 100.
5. Drummond FJ, Sowden J, Morrison K, Edwards YH. Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2. FEBS Lett 1998 423 : 218 22.
6. Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003 22 : 7942 9.
7. Kaimaktchiev V, Terracciano L, Tornillo L, Spichtin H, Stoios D, Bundi M, et al. The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. Mod Pathol 2004 17 : 1392 9.
8. Seno H, Oshima M, Taniguchi MA, Usami K, Ishikawa TO, Chiba T, et al. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int J Oncol 2002 21 : 769 74.
9. Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004 64 : 7740 7.
10. Drummond F, Putt W, Fox M, Edwards YH. Cloning and chromosome assignment of the human CDX2 gene. Ann Hum Genet 1997 61 : 393 400.
11. Yustein AS, Harper JC, Petroni GR, Cummings OW, Moskaluk CA, Powell SM. Allelotype of gastric adenocarcinoma. Cancer Res 1999 59 : 1437 41.
12. Chawengsaksophak K, James R, Hammond VE, Köntgen F, Beck F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 1997 386 : 84 7.
13. Lee JY, Dong SM, Kim SY, Yoo NJ, Lee SH, Park WS. A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections. Virchows Arch 1998 433 : 305 9.
14. Park WS, Oh RR, Kim YS, Park JY, Shin MS, Lee HK, et al. Absence of mutations in the kinase domain of the Met gene and frequent expression of Met and HGF/SF protein in primary gastric carcinomas. APMIS 2000 108 : 195 200.
15. Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, et al. The Cdx2 homeobox gene has a tumor suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 2003 52 : 1465 71.
16. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolos C, et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastirc carcinomas. J Pathol 2003 199 : 36 40.
17. Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, et al. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene 2007 [Epub ahead of print].
18. Mizoshita T, Tsukamoto T, Inada K, Ogasawara N, Hirata A, Kato S, et al. Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa. Pathol Int 2004 54 : 392 400.
19. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996 16 : 619 25.
20. Lickert H, Domon C, Huls G, Wehrle C, Duluc I, Clevers H, et al. Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine. Development 2000 127 : 3805 13.
21. Domon-Dell C, Freund JN. Stimulation of Cdx1 by oncogenic β-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homoeprotein. FEBS Lett 2002 518 : 83 7.
22. Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, et al. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis 2005 26 : 193 200.
23. Yagi OK, Akiyama Y, Yuasa Y. Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. Br J Cancer 1999 79 : 440 4.
24. Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, et al. CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene 1998 17 : 657 9.
25. da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, et al. CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. Oncogene 1999 18 : 5010 4.
26. Woodford-Richens KL, Halford S, Rowan A, Bevan S, Aaltonen LA, Wasan H, et al. CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers. Br J Cancer 2001 84 : 1314 6.