Autologous hematopoietic stem cell transplantation: The glass seems to be half full for aggressive, early forms of MS and half empty for advanced MS [2]

Brain

Volumn 131, Issue 2, 2008, Pages

  Metz, Imke ^a   Lucchinetti, Claudia F ^b   Openshaw, Harry ^c   Garcia Merino, Antonio ^d   Lassmann, Hans ^e   Freedman, Marc S ^f   Azzarelli, Biagio ^g   Kolar, Oldrich J ^g   Atkins, Harold L ^f   Brück, Wolfgang ^a,h  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MAYO CLINIC   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^e Medical University of Vienna   (Austria)

^f UNIVERSITY OF OTTAWA   (Canada)

^g INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Gemeinnutzige Hertie Stiftung   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ATROPHY; DISEASE COURSE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LETTER; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

EID: 38849202503     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm181     Document Type: Letter

References (8)

1. Chen JT, Collins DL, Atkins HL, Freedman MS, Galal A, Arnold AL, et al. Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis. Neurology 2006; 66: 1935-7.
2. Coles AJ, Wing MG, Molyneux P, Paolillo A, Davie CM, Hale G, et al. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann Neurol 1999; 46: 296-304.
3. Inglese M, Mancardi GL, Pagani E, Rocca MA, Murialdo A, Saccardi R, et al. Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J Neurol Neurosurg Psychiat 2004; 75: 643-4.
4. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707-17.
5. Martin R. Is haematopoietic stem cell transplantation a treatment option for severe MS or not? Brain 2007; 130: 1181-2.
6. Metz I, Lucchinetti CF, Openshaw H, Garcia-Merino A, Lassmann H, Freedman MS, et al. Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis. Brain 2007.
7. Muraro PA, Cassiani IR, Martin R. Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges. Curr Opin Neurol 2003; 16: 299-305.
8. Prineas JW, Kwon EE, Cho E-S, Sharer LR, Barnett MH, Oleszak EL, et al. Immunopathology of secondary-progressive multiple sclerosis. Ann Neurol 2001; 50: 646-57.