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Volumn 67, Issue 5, 2008, Pages 1094-1107

Efficient point mutagenesis in mycobacteria using single-stranded DNA recombineering: Characterization of antimycobacterial drug targets

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; ISONIAZID; OFLOXACIN; OLIGONUCLEOTIDE; PROTEIN; RIFAMPICIN; SINGLE STRANDED DNA; STREPTOMYCIN;

EID: 38849190026     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06109.x     Document Type: Article
Times cited : (121)

References (51)
  • 1
    • 0027381599 scopus 로고
    • The uraA locus and homologous recombination in Mycobacterium bovis BCG
    • Aldovini, A., Husson, R.N. Young, R.A. (1993) The uraA locus and homologous recombination in Mycobacterium bovis BCG. J Bacteriol 175 : 7282 7289.
    • (1993) J Bacteriol , vol.175 , pp. 7282-7289
    • Aldovini, A.1    Husson, R.N.2    Young, R.A.3
  • 2
    • 0034753254 scopus 로고    scopus 로고
    • Luciferase reporter mycobacteriophages for detection, identification, and antibiotic susceptibility testing of Mycobacterium tuberculosis in Mexico
    • Jr
    • Banaiee, N., Bobadilla-Del-Valle, M., Bardarov, S., Jr, Riska, P.F., Small, P.M., Ponce-De-Leon, A., et al. (2001) Luciferase reporter mycobacteriophages for detection, identification, and antibiotic susceptibility testing of Mycobacterium tuberculosis in Mexico. J Clin Microbiol 39 : 3883 3888.
    • (2001) J Clin Microbiol , vol.39 , pp. 3883-3888
    • Banaiee, N.1    Bobadilla-Del-Valle, M.2    Bardarov, S.3    Riska, P.F.4    Small, P.M.5    Ponce-De-Leon, A.6
  • 3
    • 0028156861 scopus 로고
    • InhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
    • Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K.S., Wilson, T., et al. (1994) inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263 : 227 230.
    • (1994) Science , vol.263 , pp. 227-230
    • Banerjee, A.1    Dubnau, E.2    Quemard, A.3    Balasubramanian, V.4    Um, K.S.5    Wilson, T.6
  • 4
    • 0030931885 scopus 로고    scopus 로고
    • Conditionally replicating mycobacteriophages: A system for transposon delivery to Mycobacterium tuberculosis
    • Bardarov, S., Kriakov, J., Carriere, C., Yu, S., Vaamonde, C., McAdam, R.A., et al. (1997) Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 94 : 10961 10966.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10961-10966
    • Bardarov, S.1    Kriakov, J.2    Carriere, C.3    Yu, S.4    Vaamonde, C.5    McAdam, R.A.6
  • 5
    • 0036774617 scopus 로고    scopus 로고
    • Specialized transduction: An efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis
    • Bardarov, S., Bardarov, S. Pavelka, M.S. Sambandamurthy, V., Larsen, M., Tufariello, J., et al. (2002) Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148 : 3007 3017.
    • (2002) Microbiology , vol.148 , pp. 3007-3017
    • Bardarov, S.1    Bardarov, S.2    Pavelka, M.S.3    Sambandamurthy, V.4    Larsen, M.5    Tufariello, J.6
  • 6
    • 0036033757 scopus 로고    scopus 로고
    • Integration and excision of the Mycobacterium tuberculosis prophage-like element, phiRv1
    • Bibb, L.A. Hatfull, G.F. (2002) Integration and excision of the Mycobacterium tuberculosis prophage-like element, phiRv1. Mol Microbiol 45 : 1515 1526.
    • (2002) Mol Microbiol , vol.45 , pp. 1515-1526
    • Bibb, L.A.1    Hatfull, G.F.2
  • 7
    • 0015239451 scopus 로고
    • The role of exonuclease and beta protein of phage lambda in genetic recombination. II. Substrate specificity and the mode of action of lambda exonuclease
    • Carter, D.M. Radding, C.M. (1971) The role of exonuclease and beta protein of phage lambda in genetic recombination. II. Substrate specificity and the mode of action of lambda exonuclease. J Biol Chem 246 : 2502 2512.
    • (1971) J Biol Chem , vol.246 , pp. 2502-2512
    • Carter, D.M.1    Radding, C.M.2
  • 8
    • 85045497108 scopus 로고
    • Mismatch amplification mutation assay (MAMA): Application to the c-H-ras gene
    • Cha, R.S., Zarbl, H., Keohavong, P. Thilly, W.G. (1992) Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene. PCR Methods Appl 2 : 14 20.
    • (1992) PCR Methods Appl , vol.2 , pp. 14-20
    • Cha, R.S.1    Zarbl, H.2    Keohavong, P.3    Thilly, W.G.4
  • 9
    • 0346103663 scopus 로고    scopus 로고
    • Enhanced levels of lambda Red-mediated recombinants in mismatch repair mutants
    • Costantino, N. Court, D.L. (2003) Enhanced levels of lambda Red-mediated recombinants in mismatch repair mutants. Proc Natl Acad Sci USA 100 : 15748 15753.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15748-15753
    • Costantino, N.1    Court, D.L.2
  • 10
    • 0036953835 scopus 로고    scopus 로고
    • Genetic engineering using homologous recombination
    • Court, D.L., Sawitzke, J.A. Thomason, L.C. (2002) Genetic engineering using homologous recombination. Annu Rev Genet 36 : 361 388.
    • (2002) Annu Rev Genet , vol.36 , pp. 361-388
    • Court, D.L.1    Sawitzke, J.A.2    Thomason, L.C.3
  • 11
    • 33747333128 scopus 로고    scopus 로고
    • A set of recombineering plasmids for gram-negative bacteria
    • Datta, S., Costantino, N. Court, D.L. (2006) A set of recombineering plasmids for gram-negative bacteria. Gene 379 : 109 115.
    • (2006) Gene , vol.379 , pp. 109-115
    • Datta, S.1    Costantino, N.2    Court, D.L.3
  • 12
    • 0141861069 scopus 로고    scopus 로고
    • The RD1 proteins of Mycobacterium tuberculosis: Expression in Mycobacterium smegmatis and biochemical characterization
    • Daugelat, S., Kowall, J., Mattow, J., Bumann, D., Winter, R., Hurwitz, R. Kaufmann, S.H. (2003) The RD1 proteins of Mycobacterium tuberculosis: expression in Mycobacterium smegmatis and biochemical characterization. Microbes Infect 5 : 1082 1095.
    • (2003) Microbes Infect , vol.5 , pp. 1082-1095
    • Daugelat, S.1    Kowall, J.2    Mattow, J.3    Bumann, D.4    Winter, R.5    Hurwitz, R.6    Kaufmann, S.H.7
  • 13
    • 0027536476 scopus 로고
    • Superinfection immunity of mycobacteriophage L5: Applications for genetic transformation of mycobacteria
    • Jr
    • Donnelly-Wu, M.K., Jacobs, W.R., Jr, Hatfull, G.F. (1993) Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria. Mol Microbiol 7 : 407 417.
    • (1993) Mol Microbiol , vol.7 , pp. 407-417
    • Donnelly-Wu, M.K.1    Jacobs, W.R.2    Hatfull, G.F.3
  • 14
    • 0035810938 scopus 로고    scopus 로고
    • High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
    • Ellis, H.M., Yu, D., DiTizio, T. Court, D.L. (2001) High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc Natl Acad Sci USA 98 : 6742 6746.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6742-6746
    • Ellis, H.M.1    Yu, D.2    Ditizio, T.3    Court, D.L.4
  • 15
    • 33745192630 scopus 로고    scopus 로고
    • Control of phage Bxb1 excision by a novel recombination directionality factor
    • Ghosh, P., Wasil, L.R. Hatfull, G.F. (2006) Control of phage Bxb1 excision by a novel recombination directionality factor. PLoS Biol 4 : e186.
    • (2006) PLoS Biol , vol.4
    • Ghosh, P.1    Wasil, L.R.2    Hatfull, G.F.3
  • 16
    • 0027535682 scopus 로고
    • Stable integration and expression of the Plasmodium falciparum circumsporozoite protein coding sequence in mycobacteria
    • Haeseleer, F., Pollet, J.F., Haumont, M., Bollen, A. Jacobs, P. (1993) Stable integration and expression of the Plasmodium falciparum circumsporozoite protein coding sequence in mycobacteria. Mol Biochem Parasitol 57 : 117 126.
    • (1993) Mol Biochem Parasitol , vol.57 , pp. 117-126
    • Haeseleer, F.1    Pollet, J.F.2    Haumont, M.3    Bollen, A.4    Jacobs, P.5
  • 17
    • 0028343501 scopus 로고
    • Homologous pairing and strand exchange promoted by the Escherichia coli RecT protein
    • Hall, S.D. Kolodner, R.D. (1994) Homologous pairing and strand exchange promoted by the Escherichia coli RecT protein. Proc Natl Acad Sci USA 91 : 3205 3209.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3205-3209
    • Hall, S.D.1    Kolodner, R.D.2
  • 18
    • 0027391504 scopus 로고
    • Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturation of homologous single-stranded DNA
    • Hall, S.D., Kane, M.F. Kolodner, R.D. (1993) Identification and characterization of the Escherichia coli RecT protein, a protein encoded by the recE region that promotes renaturation of homologous single-stranded DNA. J Bacteriol 175 : 277 287.
    • (1993) J Bacteriol , vol.175 , pp. 277-287
    • Hall, S.D.1    Kane, M.F.2    Kolodner, R.D.3
  • 19
    • 33745710106 scopus 로고    scopus 로고
    • Mycobacteriophages and tuberculosis
    • In. Eisenach, K., Cole, S.T., Jacobs, W.R., Jr., McMurray, D. (eds). Washington, DC: ASM Press, pp.
    • Hatfull, G.F. (2004) Mycobacteriophages and tuberculosis. In Tuberculosis. Eisenach, K., Cole, S.T., Jacobs, W.R., Jr., McMurray, D. (eds). Washington, DC : ASM Press, pp. 203 218.
    • (2004) Tuberculosis. , pp. 203-218
    • Hatfull, G.F.1
  • 20
  • 21
    • 33745661032 scopus 로고    scopus 로고
    • Selection for chromosome architecture in bacteria
    • Hendrickson, H. Lawrence, J.G. (2006) Selection for chromosome architecture in bacteria. J Mol Evol 62 : 615 629.
    • (2006) J Mol Evol , vol.62 , pp. 615-629
    • Hendrickson, H.1    Lawrence, J.G.2
  • 22
    • 33947231236 scopus 로고    scopus 로고
    • Mutational bias suggests that replication termination occurs near the dif site, not at Ter sites
    • Hendrickson, H. Lawrence, J.G. (2007) Mutational bias suggests that replication termination occurs near the dif site, not at Ter sites. Mol Microbiol 64 : 42 56.
    • (2007) Mol Microbiol , vol.64 , pp. 42-56
    • Hendrickson, H.1    Lawrence, J.G.2
  • 23
    • 0027207286 scopus 로고
    • Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages
    • Jr
    • Jacobs, W.R., Jr, Barletta, R.G., Udani, R., Chan, J., Kalkut, G., Sosne, G., et al. (1993) Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science 260 : 819 822.
    • (1993) Science , vol.260 , pp. 819-822
    • Jacobs, W.R.1    Barletta, R.G.2    Udani, R.3    Chan, J.4    Kalkut, G.5    Sosne, G.6
  • 24
    • 0021091542 scopus 로고
    • Exonuclease VIII of Escherichia coli. II. Mechanism of action
    • Joseph, J.W. Kolodner, R. (1983) Exonuclease VIII of Escherichia coli. II. Mechanism of action. J Biol Chem 258 : 10418 10424.
    • (1983) J Biol Chem , vol.258 , pp. 10418-10424
    • Joseph, J.W.1    Kolodner, R.2
  • 25
    • 0025991639 scopus 로고
    • Insertional mutagenesis and illegitimate recombination in mycobacteria
    • Jr (
    • Kalpana, G.V., Bloom, B.R. Jacobs, W.R., Jr (1991) Insertional mutagenesis and illegitimate recombination in mycobacteria. Proc Natl Acad Sci USA 88 : 5433 5437.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5433-5437
    • Kalpana, G.V.1    Bloom, B.R.2    Jacobs, W.R.3
  • 26
    • 0034041916 scopus 로고    scopus 로고
    • Genetic antagonism and hypermutability in Mycobacterium smegmatis
    • Karunakaran, P. Davies, J. (2000) Genetic antagonism and hypermutability in Mycobacterium smegmatis. J Bacteriol 182 : 3331 3335.
    • (2000) J Bacteriol , vol.182 , pp. 3331-3335
    • Karunakaran, P.1    Davies, J.2
  • 27
    • 33947357684 scopus 로고    scopus 로고
    • Recombineering in Mycobacterium tuberculosis
    • van Kessel, J.C. Hatfull, G.F. (2007) Recombineering in Mycobacterium tuberculosis. Nat Methods 4 : 147 152.
    • (2007) Nat Methods , vol.4 , pp. 147-152
    • Van Kessel, J.C.1    Hatfull, G.F.2
  • 28
    • 0142062042 scopus 로고    scopus 로고
    • Mycobacteriophage Bxb1 integrates into the Mycobacterium smegmatis groEL1 gene
    • Kim, A.I., Ghosh, P., Aaron, M.A., Bibb, L.A., Jain, S. Hatfull, G.F. (2003) Mycobacteriophage Bxb1 integrates into the Mycobacterium smegmatis groEL1 gene. Mol Microbiol 50 : 463 473.
    • (2003) Mol Microbiol , vol.50 , pp. 463-473
    • Kim, A.I.1    Ghosh, P.2    Aaron, M.A.3    Bibb, L.A.4    Jain, S.5    Hatfull, G.F.6
  • 29
    • 0019854161 scopus 로고
    • Beta protein of bacteriophage lambda promotes renaturation of DNA
    • Kmiec, E. Holloman, W.K. (1981) Beta protein of bacteriophage lambda promotes renaturation of DNA. J Biol Chem 256 : 12636 12639.
    • (1981) J Biol Chem , vol.256 , pp. 12636-12639
    • Kmiec, E.1    Holloman, W.K.2
  • 30
    • 0026323938 scopus 로고
    • Site-specific integration of mycobacteriophage L5: Integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin
    • Lee, M.H., Pascopella, L., Jacobs, W.R., Jr. Hatfull, G.F. (1991a) Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin. Proc Natl Acad Sci USA 88 : 3111 3115.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3111-3115
    • Lee, M.H.1    Pascopella, L.2    Jacobs Jr., W.R.3    Hatfull, G.F.4
  • 31
    • 0026323938 scopus 로고
    • Site-specific integration of mycobacteriophage L5: Integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin
    • Jr
    • Lee, M.H., Pascopella, L., Jacobs, W.R., Jr, Hatfull, G.F. (1991b) Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin. Proc Natl Acad Sci USA 88 : 3111 3115.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3111-3115
    • Lee, M.H.1    Pascopella, L.2    Jacobs, W.R.3    Hatfull, G.F.4
  • 32
    • 0344668833 scopus 로고    scopus 로고
    • Identification of factors influencing strand bias in oligonucleotide- mediated recombination in Escherichia coli
    • Li, X.T., Costantino, N., Lu, L.Y., Liu, D.P., Watt, R.M., Cheah, K.S., et al. (2003) Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli. Nucleic Acids Res 31 : 6674 6687.
    • (2003) Nucleic Acids Res , vol.31 , pp. 6674-6687
    • Li, X.T.1    Costantino, N.2    Lu, L.Y.3    Liu, D.P.4    Watt, R.M.5    Cheah, K.S.6
  • 33
    • 0032489359 scopus 로고    scopus 로고
    • The beta protein of phage lambda promotes strand exchange
    • Li, Z., Karakousis, G., Chiu, S.K., Reddy, G. Radding, C.M. (1998) The beta protein of phage lambda promotes strand exchange. J Mol Biol 276 : 733 744.
    • (1998) J Mol Biol , vol.276 , pp. 733-744
    • Li, Z.1    Karakousis, G.2    Chiu, S.K.3    Reddy, G.4    Radding, C.M.5
  • 34
    • 38849186955 scopus 로고    scopus 로고
    • Genomic characterization of mycobacteriophage Giles: Evidence for phage acquisition of host DNA by illegitimate recombination
    • (in press). doi:10.1128/JB.01657-07
    • Morris, P., Marinelli, L.J., Jacobs-Sera, D., Hendrix, R.W. Hatfull, G.F. (2008) Genomic characterization of mycobacteriophage Giles: evidence for phage acquisition of host DNA by illegitimate recombination. J Bacteriol (in press). doi:10.1128/JB.01657-07
    • (2008) J Bacteriol
    • Morris, P.1    Marinelli, L.J.2    Jacobs-Sera, D.3    Hendrix, R.W.4    Hatfull, G.F.5
  • 35
    • 0022912797 scopus 로고
    • The homologous recombination system of phage lambda. Pairing activities of beta protein
    • Muniyappa, K. Radding, C.M. (1986) The homologous recombination system of phage lambda. Pairing activities of beta protein. J Biol Chem 261 : 7472 7478.
    • (1986) J Biol Chem , vol.261 , pp. 7472-7478
    • Muniyappa, K.1    Radding, C.M.2
  • 36
    • 0031924072 scopus 로고    scopus 로고
    • Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli
    • Murphy, K.C. (1998) Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli. J Bacteriol 180 : 2063 2071.
    • (1998) J Bacteriol , vol.180 , pp. 2063-2071
    • Murphy, K.C.1
  • 37
    • 0034603783 scopus 로고    scopus 로고
    • PCR-mediated gene replacement in Escherichia coli
    • Murphy, K.C., Campellone, K.G. Poteete, A.R. (2000) PCR-mediated gene replacement in Escherichia coli. Gene 246 : 321 330.
    • (2000) Gene , vol.246 , pp. 321-330
    • Murphy, K.C.1    Campellone, K.G.2    Poteete, A.R.3
  • 38
    • 23044432834 scopus 로고    scopus 로고
    • New genetic approaches shed light on TB virulence
    • Murry, J.P. Rubin, E.J. (2005) New genetic approaches shed light on TB virulence. Trends Microbiol 13 : 366 372.
    • (2005) Trends Microbiol , vol.13 , pp. 366-372
    • Murry, J.P.1    Rubin, E.J.2
  • 39
    • 0033559118 scopus 로고    scopus 로고
    • Rapid modification of bacterial artificial chromosomes by ET-recombination
    • Muyrers, J.P., Zhang, Y., Testa, G. Stewart, A.F. (1999) Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 27 : 1555 1557.
    • (1999) Nucleic Acids Res , vol.27 , pp. 1555-1557
    • Muyrers, J.P.1    Zhang, Y.2    Testa, G.3    Stewart, A.F.4
  • 40
    • 0032524617 scopus 로고    scopus 로고
    • DNA strand invasion promoted by Escherichia coli RecT protein
    • Noirot, P. Kolodner, R.D. (1998) DNA strand invasion promoted by Escherichia coli RecT protein. J Biol Chem 273 : 12274 12280.
    • (1998) J Biol Chem , vol.273 , pp. 12274-12280
    • Noirot, P.1    Kolodner, R.D.2
  • 41
    • 34547886939 scopus 로고    scopus 로고
    • Comparative genomic analysis of mycobacteriophage Tweety: Evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria
    • Pham, T.T., Jacobs-Sera, D., Pedulla, M.L., Hendrix, R.W. Hatfull, G.F. (2007) Comparative genomic analysis of mycobacteriophage Tweety: evolutionary insights and construction of compatible site-specific integration vectors for mycobacteria. Microbiology 153 : 2711 2723.
    • (2007) Microbiology , vol.153 , pp. 2711-2723
    • Pham, T.T.1    Jacobs-Sera, D.2    Pedulla, M.L.3    Hendrix, R.W.4    Hatfull, G.F.5
  • 42
    • 0015239438 scopus 로고
    • The role of exonuclease and beta protein of phage lambda in genetic recombination. 3. Binding to deoxyribonucleic acid
    • Radding, C.M. Carter, D.M. (1971) The role of exonuclease and beta protein of phage lambda in genetic recombination. 3. Binding to deoxyribonucleic acid. J Biol Chem 246 : 2513 2518.
    • (1971) J Biol Chem , vol.246 , pp. 2513-2518
    • Radding, C.M.1    Carter, D.M.2
  • 43
    • 0028145935 scopus 로고
    • Characterization of mutations in Mycobacterium smegmatis involved in resistance to fluoroquinolones
    • Revel, V., Cambau, E., Jarlier, V. Sougakoff, W. (1994) Characterization of mutations in Mycobacterium smegmatis involved in resistance to fluoroquinolones. Antimicrob Agents Chemother 38 : 1991 1996.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1991-1996
    • Revel, V.1    Cambau, E.2    Jarlier, V.3    Sougakoff, W.4
  • 44
    • 33747371997 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis DeltaRD1 DeltapanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis
    • Sambandamurthy, V.K., Derrick, S.C., Hsu, T., Chen, B., Larsen, M.H., Jalapathy, K.V., et al. (2006) Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine 24 : 6309 6320.
    • (2006) Vaccine , vol.24 , pp. 6309-6320
    • Sambandamurthy, V.K.1    Derrick, S.C.2    Hsu, T.3    Chen, B.4    Larsen, M.H.5    Jalapathy, K.V.6
  • 50
    • 33748469322 scopus 로고    scopus 로고
    • Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
    • Vilcheze, C., Wang, F., Arai, M., Hazbon, M.H., Colangeli, R., Kremer, L., et al. (2006) Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med 12 : 1027 1029.
    • (2006) Nat Med , vol.12 , pp. 1027-1029
    • Vilcheze, C.1    Wang, F.2    Arai, M.3    Hazbon, M.H.4    Colangeli, R.5    Kremer, L.6


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