Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence

Brain Research

Volumn 919, Issue 1, 2001, Pages 20-30

  Shen, Ke Fei ^a   Crain, Stanley M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cholera toxin B subunit; GM1 regulated excitatory opioid receptor; Low dose and opioid hyperalgesia; Mouse tail flick assay; Opioid analgesia and tolerance dependence

Indexed keywords

CHOLERA TOXIN B SUBUNIT; GANGLIOSIDE GM1; KAPPA OPIATE RECEPTOR AGONIST; MORPHINE; NALTREXONE; OPIATE RECEPTOR;

ALLOSTERISM; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BETA CHAIN; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TOLERANCE; HYPERALGESIA; MALE; MOUSE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; RECEPTOR BLOCKING; TAIL FLICK TEST;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANALGESICS, OPIOID; ANIMALS; CELLS, CULTURED; CHOLERA TOXIN; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; HEAT; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MORPHINE; NALTREXONE; OPIOID-RELATED DISORDERS; PAIN MEASUREMENT; RECEPTORS, OPIOID; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0035900180     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02990-0     Document Type: Article

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