Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinolin-1- ones as anticonvulsant agents

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 2, 2008, Pages 181-184

  Gitto, Rosaria ^a   Francica, Eleonora ^a   De Sarro, Giovambattista ^b   Scicchitano, Francesca ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Anticonvulsant agent; Isoquinolinone; Solution phase parallel synthesis

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 3 (3'' AMINOPHENYL) N (4' CHLOROBENZYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; 3 (4'' AMINOPHENYL) N (4' CHLOROBENZYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; 3 (4'' BROMOPHENYL) N (4' CHLOROBENZYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; ANTICONVULSIVE AGENT; METHYL N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 1 OXO 3 (3'',4'' DIFLUOROPHENYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 1 OXO 3 (4'' TRIFLUOROMETHYPHENYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 1 OXO 3 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 3 (3'' NITROPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 3 (3'',4'' DIMETHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 3 (4'' FLUOROPHENYL) 1 OXO 3 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE (4 PIPERIDIN 1 YL)CARBOXAMIDE; N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 (4 METHYLPIPERAZIN 1 YL)CARBOXAMIDE; N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 (MORPHOLIN 4 YL)CARBOXAMIDE; N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLAMIDE; N (4' CHLOROBENZYL) 3 (4'' METHOXYPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 PROPYLCARBOXAMIDE; N (4' CHLOROBENZYL) 3 (4'' METHYLPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; N (4' CHLOROBENZYL) 3 (4'' NITROPHENYL) 1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 4 CARBOXYLIC ACID; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; ONE POT SYNTHESIS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; EPILEPSY, REFLEX; FEMALE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED DBA; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 38849163699     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.181     Document Type: Article

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