A one-pot synthesis of tetrahydroisoquinolonic acids from aldehydes and amines in trimethylorthoformate

Synlett

Volumn , Issue 3, 2000, Pages 355-356

  Yu, Niefang ^a   Poulain, Rebecca ^b   Gesquiere, Jean Claude ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b CEREP   (France)

Author keywords

Aldehydes; Amines; Cyclization; Orthoformate; Solvent effect

Indexed keywords

ISOQUINOLINE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CYCLIZATION; DRUG STABILITY; DRUG SYNTHESIS; POLYMERIZATION; REACTION ANALYSIS; SOLID PHASE EXTRACTION;

EID: 0034090830     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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3. Cushman, M.; Gentry, J.; Dekow, F. W. J. Org. Chem. 1977, 42, 1111.
4. Cushman, M.; Cheng, L.G. J. Org. Chem. 1978, 43, 286-288.
5. Griffith, M. C.; Dooley, C. T.; Houghten R. A.; Kiely, J. S. In Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery; Chaiken, I. M.; Janda, K. D. Eds.; American Chemical Society: Washington, DC 1996; p 50.
6. Yu, N.; Bourel, L.; Déprez, B.; Gesquiere; J. C. : Tetrahedron Lett. 1998, 39, 829.
7. 3: 315.42; MS: 316.5 (100%, M+1).