메뉴 건너뛰기




Volumn 108, Issue 3-5, 2008, Pages 196-202

Aromatase inhibitors: Assessment of biochemical efficacy measured by total body aromatase inhibition and tissue estrogen suppression

Author keywords

Anastrozole; Aromatase inhibitors; Exemestane; Letrozole; Tissue estrogens

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; ANTIESTROGEN; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTRONE; ESTRONE SULFATE; EXEMESTANE; FORMESTANE; LETROZOLE; PYRIDOGLUTETHIMIDE;

EID: 38849158565     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.09.017     Document Type: Article
Times cited : (19)

References (65)
  • 1
    • 0016144225 scopus 로고
    • Successful medical adrenalectomy with aminoglutethimide
    • Santen R.J., Lipton A., and Kendall J. Successful medical adrenalectomy with aminoglutethimide. JAMA 230 (1974) 1661-1665
    • (1974) JAMA , vol.230 , pp. 1661-1665
    • Santen, R.J.1    Lipton, A.2    Kendall, J.3
  • 2
    • 0017691307 scopus 로고
    • Adrenal suppression with aminoglutethimide. II. Differential effects of aminoglutethimide on plasma androstenedione and estrogen levels
    • Samojlik E., Santen R.J., and Wells S.A. Adrenal suppression with aminoglutethimide. II. Differential effects of aminoglutethimide on plasma androstenedione and estrogen levels. J. Clin. Endocrinol. Metab. 45 (1977) 480-487
    • (1977) J. Clin. Endocrinol. Metab. , vol.45 , pp. 480-487
    • Samojlik, E.1    Santen, R.J.2    Wells, S.A.3
  • 3
    • 0018217717 scopus 로고
    • Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma
    • Santen R.J., Santner S., Davis B., Veldhuis J., Samojlik E., and Ruby E. Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma. J. Clin. Endocrinol. Metab. 47 (1978) 1257-1265
    • (1978) J. Clin. Endocrinol. Metab. , vol.47 , pp. 1257-1265
    • Santen, R.J.1    Santner, S.2    Davis, B.3    Veldhuis, J.4    Samojlik, E.5    Ruby, E.6
  • 4
    • 0023726485 scopus 로고
    • Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer
    • Lønning P.E., and Kvinnsland S. Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer. Drugs 35 (1988) 685-710
    • (1988) Drugs , vol.35 , pp. 685-710
    • Lønning, P.E.1    Kvinnsland, S.2
  • 5
    • 0017755181 scopus 로고
    • The effect of an aromatase inhbitor, 4-hydroxy-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer
    • Brodie A.M.H., Schwarzel W.C., Shaikh A.A., and Brodie H.J. The effect of an aromatase inhbitor, 4-hydroxy-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer. Endocrinology 100 (1977) 1684-1695
    • (1977) Endocrinology , vol.100 , pp. 1684-1695
    • Brodie, A.M.H.1    Schwarzel, W.C.2    Shaikh, A.A.3    Brodie, H.J.4
  • 6
    • 0018743823 scopus 로고
    • Aromatase inhibitors-IV regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione
    • Brodie A.M.H., Marsh D., and Brodie H.J. Aromatase inhibitors-IV regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione. J. Steroid Biochem. 10 (1979) 423-429
    • (1979) J. Steroid Biochem. , vol.10 , pp. 423-429
    • Brodie, A.M.H.1    Marsh, D.2    Brodie, H.J.3
  • 7
    • 0019800997 scopus 로고
    • Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo
    • Brodie A.M.H., Garrett W.M., Hendrickson J.R., Tsai-Morris C.-H., Marcotte P.A., and Robinson C.H. Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo. Steroids 38 (1981) 693-702
    • (1981) Steroids , vol.38 , pp. 693-702
    • Brodie, A.M.H.1    Garrett, W.M.2    Hendrickson, J.R.3    Tsai-Morris, C.-H.4    Marcotte, P.A.5    Robinson, C.H.6
  • 8
    • 0025305715 scopus 로고
    • Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer
    • Lønning P.E., Dowsett M., and Powles T.J. Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer. J. Steroid Biochem. 35 (1990) 355-366
    • (1990) J. Steroid Biochem. , vol.35 , pp. 355-366
    • Lønning, P.E.1    Dowsett, M.2    Powles, T.J.3
  • 9
    • 0034016224 scopus 로고    scopus 로고
    • Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues
    • Chetrite G.S., CortesPrieto J., Philippe J.C., Wright F., and Pasqualini J.R. Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J. Steroid Biochem. Mol. Biol. 72 (2000) 23-27
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.72 , pp. 23-27
    • Chetrite, G.S.1    CortesPrieto, J.2    Philippe, J.C.3    Wright, F.4    Pasqualini, J.R.5
  • 10
    • 17344379365 scopus 로고    scopus 로고
    • Stepwise estrogen suppression manipulating the estrostat
    • Lønning P.E. Stepwise estrogen suppression manipulating the estrostat. J. Steroid Biochem. Mol. Biol. 79 (2001) 127-132
    • (2001) J. Steroid Biochem. Mol. Biol. , vol.79 , pp. 127-132
    • Lønning, P.E.1
  • 11
    • 23844485296 scopus 로고    scopus 로고
    • Endocrine effects of aromatase inhibitors and inactivators in vivo: review of data and method limitations
    • Geisler J., and Lønning P.E. Endocrine effects of aromatase inhibitors and inactivators in vivo: review of data and method limitations. J. Steroid Biochem. Mole. Biol. 95 (2005) 75-81
    • (2005) J. Steroid Biochem. Mole. Biol. , vol.95 , pp. 75-81
    • Geisler, J.1    Lønning, P.E.2
  • 12
    • 0021931084 scopus 로고
    • Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue
    • vanLandeghem A.A.J., Poortman J., Nabuurs M., and Thijssen J.H.H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue. Cancer Res. 45 (1985) 2900-2904
    • (1985) Cancer Res. , vol.45 , pp. 2900-2904
    • vanLandeghem, A.A.J.1    Poortman, J.2    Nabuurs, M.3    Thijssen, J.H.H.4
  • 13
    • 0023831082 scopus 로고
    • Aromatase activity in adipose tissue from breast quadrants: a link with tumour site
    • O'Neill J.S., Elton R.A., and Miller W.R. Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br. Med. J. 296 (1988) 741-743
    • (1988) Br. Med. J. , vol.296 , pp. 741-743
    • O'Neill, J.S.1    Elton, R.A.2    Miller, W.R.3
  • 14
    • 0019976895 scopus 로고
    • Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol
    • Thorsen T., Tangen M., and Støa K.F. Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol. Eur. J. Cancer Clin. Oncol. 18 (1982) 333-337
    • (1982) Eur. J. Cancer Clin. Oncol. , vol.18 , pp. 333-337
    • Thorsen, T.1    Tangen, M.2    Støa, K.F.3
  • 15
    • 0017683005 scopus 로고
    • Estrone and estradiol content in human breast tumors: relationship to estradiol receptors
    • Fishman J., Nisselbaum J.S., Menendez-Botet C.J., and Schwartz M.K. Estrone and estradiol content in human breast tumors: relationship to estradiol receptors. J. Steroid Biochem. 8 (1977) 893-896
    • (1977) J. Steroid Biochem. , vol.8 , pp. 893-896
    • Fishman, J.1    Nisselbaum, J.S.2    Menendez-Botet, C.J.3    Schwartz, M.K.4
  • 16
    • 0019346536 scopus 로고
    • Endogenous oestradiol-17β concentration in breast tumours determined by mass fragmnentography and by radioimmunoassay: relationship to receptor content
    • Edery M., Goussard J., Dehennin L., Scholler R., Reiffsteck J., and Drosdowsky M.A. Endogenous oestradiol-17β concentration in breast tumours determined by mass fragmnentography and by radioimmunoassay: relationship to receptor content. Eur. J. Cancer 17 (1980) 115-120
    • (1980) Eur. J. Cancer , vol.17 , pp. 115-120
    • Edery, M.1    Goussard, J.2    Dehennin, L.3    Scholler, R.4    Reiffsteck, J.5    Drosdowsky, M.A.6
  • 17
    • 0022642042 scopus 로고
    • Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women
    • Vermeulen A., Deslypere J.P., Paridaens R., Leclerco G., Roy F., and Heuson J.C. Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur. J. Cancer Clin. Oncol. 22 (1986) 515-525
    • (1986) Eur. J. Cancer Clin. Oncol. , vol.22 , pp. 515-525
    • Vermeulen, A.1    Deslypere, J.P.2    Paridaens, R.3    Leclerco, G.4    Roy, F.5    Heuson, J.C.6
  • 18
    • 0025992953 scopus 로고
    • Regulation of oestradiol 17β hydroxysteroid dehydrogenase in breast tissues: the role of growth factors
    • Reed M.J., Singh A., Ghilchik M.W., Coldham N.G., and Purohit A. Regulation of oestradiol 17β hydroxysteroid dehydrogenase in breast tissues: the role of growth factors. J. Steroid Biochem. Mol. Biol. 39 (1991) 791-798
    • (1991) J. Steroid Biochem. Mol. Biol. , vol.39 , pp. 791-798
    • Reed, M.J.1    Singh, A.2    Ghilchik, M.W.3    Coldham, N.G.4    Purohit, A.5
  • 19
    • 0026539687 scopus 로고
    • Breast tumor-derived factors stimulate reduction of estrone to estradiol in nonmalignant breast tissue
    • Mehta R.R., and Graves J.M. Breast tumor-derived factors stimulate reduction of estrone to estradiol in nonmalignant breast tissue. Breast Cancer Res. 23 (1992) 51-56
    • (1992) Breast Cancer Res. , vol.23 , pp. 51-56
    • Mehta, R.R.1    Graves, J.M.2
  • 21
    • 0033555597 scopus 로고    scopus 로고
    • Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer
    • Utsumi T., Yoshimura N., Takeuchi S., Ando J., Maruta M., Maeda K., and Harada N. Steroid sulfatase expression is an independent predictor of recurrence in human breast cancer. Cancer Res. 59 (1999) 377-381
    • (1999) Cancer Res. , vol.59 , pp. 377-381
    • Utsumi, T.1    Yoshimura, N.2    Takeuchi, S.3    Ando, J.4    Maruta, M.5    Maeda, K.6    Harada, N.7
  • 22
    • 0026609036 scopus 로고
    • Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer
    • Pasqualini J.R., Schatz B., Varin C., and Nguyen B.L. Recent data on estrogen sulfatases and sulfotransferases activities in human breast cancer. J. Steroid Biochem. Mol. Biol. 41 (1992) 323-329
    • (1992) J. Steroid Biochem. Mol. Biol. , vol.41 , pp. 323-329
    • Pasqualini, J.R.1    Schatz, B.2    Varin, C.3    Nguyen, B.L.4
  • 23
    • 0018286242 scopus 로고
    • Metabolism of estrogens-natural and synthetic
    • Bolt H.M. Metabolism of estrogens-natural and synthetic. Pharm. Ther. 4 (1979) 155-181
    • (1979) Pharm. Ther. , vol.4 , pp. 155-181
    • Bolt, H.M.1
  • 24
    • 0242626166 scopus 로고    scopus 로고
    • The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters
    • Bulun S.E., Sebastian S., Takayama K., Suzuki T., Sasano H., and Shozu M. The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. J. Steroid Biochem. Mol. Biol. 86 (2003) 219-224
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.86 , pp. 219-224
    • Bulun, S.E.1    Sebastian, S.2    Takayama, K.3    Suzuki, T.4    Sasano, H.5    Shozu, M.6
  • 25
    • 23744492069 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue
    • Chen S., Ye J.J., Kijima I., Kinoshita Y., and Zhou D.J. Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. J. Steroid Biochem. Mol. Biol. 95 (2005) 17-23
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.95 , pp. 17-23
    • Chen, S.1    Ye, J.J.2    Kijima, I.3    Kinoshita, Y.4    Zhou, D.J.5
  • 26
    • 0002507276 scopus 로고
    • Importance of intratumour aromatase, and its susceptibility to inhibitors
    • Dowsett M. (Ed), Partenon Publishing Group, London
    • Miller W.R. Importance of intratumour aromatase, and its susceptibility to inhibitors. In: Dowsett M. (Ed). Aromatase Inhibition-Then, Now and Tomorrow (1994), Partenon Publishing Group, London 43-53
    • (1994) Aromatase Inhibition-Then, Now and Tomorrow , pp. 43-53
    • Miller, W.R.1
  • 27
    • 0029055705 scopus 로고
    • Molecular and epidemiologic analyses of abnormal expression of aromatase in breast-cancer
    • Harada N., Utsumi T., and Takagi Y. Molecular and epidemiologic analyses of abnormal expression of aromatase in breast-cancer. Pharmacogenetics 5 (1995) S59-S64
    • (1995) Pharmacogenetics , vol.5
    • Harada, N.1    Utsumi, T.2    Takagi, Y.3
  • 28
    • 0030444771 scopus 로고    scopus 로고
    • Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE(2) via cyclic AMP, reading to activation of promoter II of the CYP19 (aromatase) gene
    • Zhao Y., Agarwal V.R., Mendelson C.R., and Simpson E.R. Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE(2) via cyclic AMP, reading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137 (1996) 5739-5742
    • (1996) Endocrinology , vol.137 , pp. 5739-5742
    • Zhao, Y.1    Agarwal, V.R.2    Mendelson, C.R.3    Simpson, E.R.4
  • 30
    • 0029887272 scopus 로고    scopus 로고
    • Presence of alternatively spliced transcripts of aromatase gene in human breast cancer
    • Utsumi T., Harada N., Maruta M., and Takagi Y. Presence of alternatively spliced transcripts of aromatase gene in human breast cancer. J. Clin. Endocrinol. Metabol. 81 (1996) 2344-2349
    • (1996) J. Clin. Endocrinol. Metabol. , vol.81 , pp. 2344-2349
    • Utsumi, T.1    Harada, N.2    Maruta, M.3    Takagi, Y.4
  • 32
    • 0031058694 scopus 로고    scopus 로고
    • Mechanism for maintenance of high breast tumor estradiol concentrations in the absence of ovarian function: role of very high affinity tissue uptake
    • Masamura S., Santner S.J., Gimotty P., George J., and Santen R.J. Mechanism for maintenance of high breast tumor estradiol concentrations in the absence of ovarian function: role of very high affinity tissue uptake. Breast Cancer Res. Treat. 42 (1997) 215-226
    • (1997) Breast Cancer Res. Treat. , vol.42 , pp. 215-226
    • Masamura, S.1    Santner, S.J.2    Gimotty, P.3    George, J.4    Santen, R.J.5
  • 33
    • 38849152328 scopus 로고    scopus 로고
    • V.H.T. James, M.J. Reed, E.F. Adams, M. Ghilchik, L.C. Lai, N.G. Coldham, C.J. Newton, A. Purohit, A.M. Owen, C.J. Singh, et al., Oestrogen uptake and metabolism in vivo, in: J.S. Beck (Ed.), Oestrogens and the Human Breast. Proc. R. Soc. Edinburgh 95B, 1989, pp. 185-193.
    • V.H.T. James, M.J. Reed, E.F. Adams, M. Ghilchik, L.C. Lai, N.G. Coldham, C.J. Newton, A. Purohit, A.M. Owen, C.J. Singh, et al., Oestrogen uptake and metabolism in vivo, in: J.S. Beck (Ed.), Oestrogens and the Human Breast. Proc. R. Soc. Edinburgh 95B, 1989, pp. 185-193.
  • 34
    • 0027996965 scopus 로고
    • Analysis of the aromatase cytochrome P450 gene in human breast cancers
    • Sourdaine P., Parker M.G., Telford J., and Miller W.R. Analysis of the aromatase cytochrome P450 gene in human breast cancers. J. Mol. Endocrinol. 13 (1994) 331-337
    • (1994) J. Mol. Endocrinol. , vol.13 , pp. 331-337
    • Sourdaine, P.1    Parker, M.G.2    Telford, J.3    Miller, W.R.4
  • 35
    • 0024581375 scopus 로고
    • Separation of urinary metabolites of radiolabelled estrogens in man by HPLC
    • Lønning P.E., Skulstad P., Sunde A., and Thorsen T. Separation of urinary metabolites of radiolabelled estrogens in man by HPLC. J. Steroid Biochem. 32 (1989) 91-97
    • (1989) J. Steroid Biochem. , vol.32 , pp. 91-97
    • Lønning, P.E.1    Skulstad, P.2    Sunde, A.3    Thorsen, T.4
  • 36
    • 0026090289 scopus 로고
    • Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo
    • Jacobs S., Lønning P.E., Haynes B., Griggs L., and Dowsett M. Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo. J. Enzyme Inhib. 4 (1991) 315-325
    • (1991) J. Enzyme Inhib. , vol.4 , pp. 315-325
    • Jacobs, S.1    Lønning, P.E.2    Haynes, B.3    Griggs, L.4    Dowsett, M.5
  • 37
    • 0018595494 scopus 로고
    • Inhibition of peripheral aromatization of androstenedione to estrone in postmenopausal women with breast cancer using {Eth}1-testoloclactone
    • Barone R.M., Shamonki I.M., Siiteri P.K., and Judd H.L. Inhibition of peripheral aromatization of androstenedione to estrone in postmenopausal women with breast cancer using {Eth}1-testoloclactone. J. Clin. Endocrinol. Metab. 49 (1979) 672-676
    • (1979) J. Clin. Endocrinol. Metab. , vol.49 , pp. 672-676
    • Barone, R.M.1    Shamonki, I.M.2    Siiteri, P.K.3    Judd, H.L.4
  • 38
    • 0025128964 scopus 로고
    • Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer
    • Reed M.J., Lai L.C., Owen A.M., Singh A., Coldham N.G., Purohit A., Ghilchik M.W., Shaikh N.A., and James V.H.T. Effect of treatment with 4-hydroxyandrostenedione on the peripheral conversion of androstenedione to estrone and in vitro tumor aromatase activity in postmenopausal women with breast cancer. Cancer Res. 50 (1990) 193-196
    • (1990) Cancer Res. , vol.50 , pp. 193-196
    • Reed, M.J.1    Lai, L.C.2    Owen, A.M.3    Singh, A.4    Coldham, N.G.5    Purohit, A.6    Ghilchik, M.W.7    Shaikh, N.A.8    James, V.H.T.9
  • 39
    • 0027443281 scopus 로고
    • Inhibition of the in vivo conversion of androstenedione to estrone by the aromatase inhibitor vorozole in healthy postmenopausal women
    • Wall E.v.d., Donker T.H., Frankrijker E.d., Nortier H.W.R., Thijssen J.H.H., and Blankenstein M.A. Inhibition of the in vivo conversion of androstenedione to estrone by the aromatase inhibitor vorozole in healthy postmenopausal women. Cancer Res. 53 (1993) 4563-4566
    • (1993) Cancer Res. , vol.53 , pp. 4563-4566
    • Wall, E.v.d.1    Donker, T.H.2    Frankrijker, E.d.3    Nortier, H.W.R.4    Thijssen, J.H.H.5    Blankenstein, M.A.6
  • 40
    • 0025793984 scopus 로고
    • The influence of CGS 16949A on peripheral aromatisation in breast cancer patients
    • Lønning P.E., Jacobs S., Jones A., Haynes B., Powles T., and Dowsett M. The influence of CGS 16949A on peripheral aromatisation in breast cancer patients. Br. J. Cancer 63 (1991) 789-793
    • (1991) Br. J. Cancer , vol.63 , pp. 789-793
    • Lønning, P.E.1    Jacobs, S.2    Jones, A.3    Haynes, B.4    Powles, T.5    Dowsett, M.6
  • 41
    • 0026639780 scopus 로고
    • The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients
    • Jones A.L., MacNeill F., Jacobs S., Lønning P.E., Dowsett M., and Powles T.J. The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients. Eur. J. Cancer 28A (1992) 1712-1716
    • (1992) Eur. J. Cancer , vol.28 A , pp. 1712-1716
    • Jones, A.L.1    MacNeill, F.2    Jacobs, S.3    Lønning, P.E.4    Dowsett, M.5    Powles, T.J.6
  • 42
    • 0026698078 scopus 로고
    • The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer
    • MacNeill F.A., Jones A.L., Jacobs S., Lønning P.E., Powles T.J., and Dowsett M. The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer. Br. J. Cancer 66 (1992) 692-697
    • (1992) Br. J. Cancer , vol.66 , pp. 692-697
    • MacNeill, F.A.1    Jones, A.L.2    Jacobs, S.3    Lønning, P.E.4    Powles, T.J.5    Dowsett, M.6
  • 43
    • 0028275330 scopus 로고
    • Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression
    • MacNeill F.A., Jacobs S., Lønning P.E., Powles T.J., and Dowsett M. Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression. Br. J. Cancer 69 (1994) 1171-1175
    • (1994) Br. J. Cancer , vol.69 , pp. 1171-1175
    • MacNeill, F.A.1    Jacobs, S.2    Lønning, P.E.3    Powles, T.J.4    Dowsett, M.5
  • 44
    • 0029058421 scopus 로고
    • The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients
    • MacNeill F.A., Jacobs S., Dowsett M., Lønning P.E., and Powles T.J. The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients. Cancer Chemother. Pharmacol. 36 (1995) 249-254
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 249-254
    • MacNeill, F.A.1    Jacobs, S.2    Dowsett, M.3    Lønning, P.E.4    Powles, T.J.5
  • 45
    • 0029560237 scopus 로고
    • In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in post menopausal patients with breast cancer
    • Dowsett M., Jones A., Johnston S.R.D., Jacobs S., Trunet P., and Smith I.E. In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in post menopausal patients with breast cancer. Clin. Cancer Res. 1 (1995) 1511-1515
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1511-1515
    • Dowsett, M.1    Jones, A.2    Johnston, S.R.D.3    Jacobs, S.4    Trunet, P.5    Smith, I.E.6
  • 47
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Geisler J., King N., Anker G., Ornati G., DiSalle E., Lønning P.E., and Dowsett M. In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clin. Cancer Res. 4 (1998) 2089-2093
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3    Ornati, G.4    DiSalle, E.5    Lønning, P.E.6    Dowsett, M.7
  • 48
    • 0036467847 scopus 로고    scopus 로고
    • Influence of letrozole (Femara) and anastrozole (Arimidex) on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over-designed study
    • Geisler J., Haynes B., Anker G., Dowsett M., and Lønning P.E. Influence of letrozole (Femara) and anastrozole (Arimidex) on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over-designed study. J. Clin. Oncol. 20 (2002) 751-757
    • (2002) J. Clin. Oncol. , vol.20 , pp. 751-757
    • Geisler, J.1    Haynes, B.2    Anker, G.3    Dowsett, M.4    Lønning, P.E.5
  • 49
    • 3042545132 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • Lønning P.E. Aromatase inhibitors in breast cancer. End-Rel-Cancer 11 (2004) 179-189
    • (2004) End-Rel-Cancer , vol.11 , pp. 179-189
    • Lønning, P.E.1
  • 51
    • 0035890568 scopus 로고    scopus 로고
    • Sequential tamoxifen and aminoglutethimide versus tamoxifen alone in the adjuvant treatment of postmenopausal breast cancer patients: results of an Italian cooperative study
    • Boccardo F., Rubagotti A., Amoroso D., Mesiti M., Romeo D., Caroti C., Farris A., Cruciani G., Villa E., Schieppati G., et al. Sequential tamoxifen and aminoglutethimide versus tamoxifen alone in the adjuvant treatment of postmenopausal breast cancer patients: results of an Italian cooperative study. J. Clin. Oncol. 19 (2001) 4209-4215
    • (2001) J. Clin. Oncol. , vol.19 , pp. 4209-4215
    • Boccardo, F.1    Rubagotti, A.2    Amoroso, D.3    Mesiti, M.4    Romeo, D.5    Caroti, C.6    Farris, A.7    Cruciani, G.8    Villa, E.9    Schieppati, G.10
  • 52
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Howell A., Cuzick J., Baum M., Buzdar A., Dowsett M., Forbes J.F., Hoctin-Boes G., Houghton I., Locker G.Y., Tobias J.S., et al. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365 (2005) 60-62
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3    Buzdar, A.4    Dowsett, M.5    Forbes, J.F.6    Hoctin-Boes, G.7    Houghton, I.8    Locker, G.Y.9    Tobias, J.S.10
  • 54
    • 24644519961 scopus 로고    scopus 로고
    • Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: preliminary results of the Italian Tamoxifen Anastrozole trial
    • Boccardo F., Rubagotti A., Puntoni M., Guglielmini P., Amoroso D., Fini A., Paladini G., Mesiti M., Romeo D., Rinaldini M., et al. Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: preliminary results of the Italian Tamoxifen Anastrozole trial. J. Clin. Oncol. 23 (2005) 5138-5147
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5138-5147
    • Boccardo, F.1    Rubagotti, A.2    Puntoni, M.3    Guglielmini, P.4    Amoroso, D.5    Fini, A.6    Paladini, G.7    Mesiti, M.8    Romeo, D.9    Rinaldini, M.10
  • 56
    • 23444446523 scopus 로고    scopus 로고
    • Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial
    • Jakesz R., Jonat W., Gnant M., Mittlboeck M., Greil R., Tausch C., Hilfrich J., Kwasny W., Menzel C., Samonigg H., et al. Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. Lancet 366 (2005) 455-462
    • (2005) Lancet , vol.366 , pp. 455-462
    • Jakesz, R.1    Jonat, W.2    Gnant, M.3    Mittlboeck, M.4    Greil, R.5    Tausch, C.6    Hilfrich, J.7    Kwasny, W.8    Menzel, C.9    Samonigg, H.10
  • 57
    • 0034177586 scopus 로고    scopus 로고
    • A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue
    • Geisler J., Berntsen H., and Lonning P.E. A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue. J. Steroid Biochem. Mol. Biol. 72 (2000) 259-264
    • (2000) J. Steroid Biochem. Mol. Biol. , vol.72 , pp. 259-264
    • Geisler, J.1    Berntsen, H.2    Lonning, P.E.3
  • 58
    • 0031739178 scopus 로고    scopus 로고
    • Effects of letrozole as primary medical therapy on in situ oestrogen synthesis and endogenous oestrogen levels within the breast
    • Miller W.R., Telford J., Love C., Leonard R.C.F., Hillier S., Gundacker H., Smith H., and Dixon J.M. Effects of letrozole as primary medical therapy on in situ oestrogen synthesis and endogenous oestrogen levels within the breast. Breast 7 (1998) 273-276
    • (1998) Breast , vol.7 , pp. 273-276
    • Miller, W.R.1    Telford, J.2    Love, C.3    Leonard, R.C.F.4    Hillier, S.5    Gundacker, H.6    Smith, H.7    Dixon, J.M.8
  • 59
    • 0034901971 scopus 로고    scopus 로고
    • Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer
    • Geisler J., Detre S., Berntsen H., Ottestad L., Lindtjørn B., Dowsett M., and Lønning P.E. Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer. Clin. Cancer Res. 7 (2001) 1230-1236
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1230-1236
    • Geisler, J.1    Detre, S.2    Berntsen, H.3    Ottestad, L.4    Lindtjørn, B.5    Dowsett, M.6    Lønning, P.E.7
  • 60
    • 17144423592 scopus 로고    scopus 로고
    • Aromatase inhibition-translation into a successful therapeutic approach
    • Geisler J., and Lønning P.E. Aromatase inhibition-translation into a successful therapeutic approach. Clin. Cancer Res. 11 (2005) 2809-2821
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2809-2821
    • Geisler, J.1    Lønning, P.E.2
  • 61
    • 0024321399 scopus 로고
    • Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide
    • Lønning P.E., Johannessen D.C., and Thorsen T. Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide. Br. J. Cancer 60 (1989) 107-111
    • (1989) Br. J. Cancer , vol.60 , pp. 107-111
    • Lønning, P.E.1    Johannessen, D.C.2    Thorsen, T.3
  • 62
    • 0023606126 scopus 로고
    • Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients
    • Lønning P.E., Kvinnsland S., Thorsen T., and Ueland P.M. Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients. Clin. Pharmacokinet. 13 (1987) 393-406
    • (1987) Clin. Pharmacokinet. , vol.13 , pp. 393-406
    • Lønning, P.E.1    Kvinnsland, S.2    Thorsen, T.3    Ueland, P.M.4
  • 63
    • 0024357684 scopus 로고
    • Effects of aminoglutethimide on plasma estrone sulfate not caused by aromatase inhibition
    • Lønning P.E., Johannessen D.C., Thorsen T., and Ekse D. Effects of aminoglutethimide on plasma estrone sulfate not caused by aromatase inhibition. J. Steroid Biochem. 33 (1989) 541-545
    • (1989) J. Steroid Biochem. , vol.33 , pp. 541-545
    • Lønning, P.E.1    Johannessen, D.C.2    Thorsen, T.3    Ekse, D.4
  • 64
    • 33750684835 scopus 로고    scopus 로고
    • Letrozole (Femara) causes potent suppression of breast cancer tissue estrogen levels in the neoadjuvant setting
    • Geisler J., Helle S., Ekse D., Duong N., Evans D., and Lonning P. Letrozole (Femara) causes potent suppression of breast cancer tissue estrogen levels in the neoadjuvant setting. J. Clin. Oncol. 24 (2006) 570s
    • (2006) J. Clin. Oncol. , vol.24
    • Geisler, J.1    Helle, S.2    Ekse, D.3    Duong, N.4    Evans, D.5    Lonning, P.6
  • 65
    • 38849176930 scopus 로고    scopus 로고
    • Letrozole suppresses tissue and plasma estradiol, estrone and estrone sulfate more effectively compared to anastrozole
    • Baltimore, Maryland, USA, September 18-20
    • Geisler J., Helle H., Ekse D., Duong N.K., Aas T., and Lønning P.E. Letrozole suppresses tissue and plasma estradiol, estrone and estrone sulfate more effectively compared to anastrozole. VIII International Aromatase Conference. Baltimore, Maryland, USA, September 18-20 (2006) 2006
    • (2006) VIII International Aromatase Conference , pp. 2006
    • Geisler, J.1    Helle, H.2    Ekse, D.3    Duong, N.K.4    Aas, T.5    Lønning, P.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.