Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes

Journal of Biochemistry

Volumn 142, Issue 5, 2007, Pages 639-645

  Nakano, Norihiko ^a,d   Miyazawa, Nobuko ^a   Sakurai, Takuya ^a   Kizaki, Takako ^a   Kimoto, Kiyoko ^a   Takahashi, Kazuto ^a   Ishida, Hitoshi ^a   Takahashi, Motoko ^b   Suzuki, Kenji ^c   Ohno, Hideki ^a  

^a KYORIN UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c RITSUMEIKAN UNIVERSITY   (Japan)

^d Aino Institute of Regeneration and Rehabilitation   (Japan)

Author keywords

Adipocyte; EGF; Gliclazide; PPAR ; Proliferation and differentiation

Indexed keywords

DIAZOXIDE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLIBENCLAMIDE; GLICLAZIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIPID STORAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN DNA BINDING; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE;

ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DIAZOXIDE; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLICLAZIDE; GLYBURIDE; HYPOGLYCEMIC AGENTS; MICE; PHOSPHORYLATION; PPAR GAMMA; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SULFONYLUREA COMPOUNDS;

EID: 38849157816     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvm172     Document Type: Article

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