Modelling of cell deaths and cell transformations of inhaled radon in homes and mines based on a biophysical and microdosimetric model

International Journal of Radiation Biology

Volumn 84, Issue 2, 2008, Pages 127-138

  Szoke, István ^a   Farkas, Árpád ^a   Balásházy, Imre ^a   Hofmann, Werner ^b  

^a KFKI ATOMIC ENERGY RESEARCH INSTITUTE   (Hungary)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Lung; Microdosimetry; Modelling; Radon

Indexed keywords

RADON; RADON DAUGHTER; URANIUM;

AIR POLLUTION; ARTICLE; CELL COUNT; CELL DEATH; CELL TRANSFORMATION; COMPUTATIONAL FLUID DYNAMICS; CONCENTRATION RESPONSE; DATA ANALYSIS; DOSIMETRY; ENVIRONMENTAL EXPOSURE; LUNG MODEL; MATHEMATICAL MODEL; MICRODOSIMETRY; MINING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGENY; RADIATION DOSE DISTRIBUTION; RADIATION EXPOSURE; UNITED STATES;

AIR POLLUTANTS, RADIOACTIVE; AIR POLLUTION, INDOOR; BODY BURDEN; CELL DEATH; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; INHALATION; LUNG; MINING; MODELS, BIOLOGICAL; NEW MEXICO; RADIOMETRY; RADON;

EID: 38849147638     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000701817076     Document Type: Article

References (34)

1. Balásházy I, Hofmann W, Farkas Á, Szoke I. 2002. Modelling carcinogenic effects of low doses of inhaled radon progenies. Journal of Radiological Protection 22:A89-93.
2. Balásházy I, Hofmann W. 1999. Computation of local enhancement factors for the quantification of particle deposition patterns in airway bifurcations. Journal of Aerosol Science 30:185-203.
3. Böhm R, Nikodemova D, Holy K. 2003. Use of various microdosimetric models for the prediction of radon induced damage in human lungs. Radiation Protection Dosimetry 104:127-137.
4. Chadwick KK, Leenhouts HP, Brugmans MJP. 2003. A contribution to the linear no-threshold discussion. Journal of Radiological Protection 23:53-77.
5. Churg A, Vedal S. 1996. Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: Evidence for high particle concentration at airway carinas. Occupational and Environmental Medicine 53:553-558.
6. Cooper JA, Jackson Po, Langford JC, Petersen MR, Stuart BO. 1973. Characteristics of attached radon-222 daughters under both laboratory and field conditions with particular emphasis upon underground mine environments. (Report to the U.S. Bureau of Mines under contract H0220029). Battle: Pacific Northwest Laboratories.
7. Crawford-Brown DJ, Hofmann W. 1991. An effect-specific track length model for radiation of intermediate to high LET. Radiation Research 126:162-170.
8. Crawford-Brown DJ, Hofmann W. 2002. Analysis of radon-induced lung cancer risk by a stochastic state-vector model of radiation carcinogenesis. Journal of Radiological Protection 22:A61-65.
9. Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochiccio F, Deo H, Falk R, Forastierre F, Hakama M, Heid I, Kreinbrock L, Kreuzer M, Lagarde F, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann HE, Doll R. 2005. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ 330:223-226.
10. Fakir H, Hofmann W, Aubineau-Lanièce I. 2005. Microdosimetry of radon progeny alpha particles in bronchial airway bifurcations. Radiation Protection Dosimetry 117:382-394.
11. Farkas Á, Balásházy I, Szocs K. 2006. Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. Journal of Aerosol Medicine 19:329-343.
12. FLUENT Manual 2001, Lebanon: Fluent Inc.
13. Haninger T. 1997. Size distributions of radon progeny and their influence on lung dose. Radon and thoron in the human environment. In: Katase A, Shima M, editors. Proceedings of the 7th Tohwa University International Symposium. Singapore, New Jersey, London, Hong Kong: World Scientific.
14. Hegedus CsJ, Balásházy I, Farkas Á. 2004. Detailed mathematical description of the geometry of airway bifurcations. Respiratory Physiology & Neurobiology 141:99-114.
15. International Commission on Radiological Protection (ICRP). 1994. Human respiratory tract model for radiation protection. ICRP Publication 66. International Commission on Radiological Protection. Oxford: Pergamon.
16. International Commission on Radiation Units (ICRU). 1993. Stopping powers and ranges for proton and alpha particles. ICRU Report 49. Bethesda: International Commission on Radiation Units and Measurements, Inc.
17. James AC, Birchall A, Akabani G. 2004. Comparative dosimetry of BEIR VI revisited. Radiation Protection Dosimetry 108:3-26.
18. Kim CS, Fisher DM. 1999. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Science and Technology 31:198-220.
19. Kinsara AA, Loyalka SK, Tompson RV, Miller WH, Holub RF. 1995. Deposition pattern of molecular phase radon daughters (Po 218) in lung bifurcations. Health Physics 68:371-381.
20. Klebanov L, Rachev S, Yakovlev A. 1993. A stochastic model of radiation carcinogenesis: Latent distributions and their properties. Mathematical Biosciences 113:51-75.
21. Koblinger L, Hofmann W. 1988. Monte Carlo model for aerosol distribution in human lungs. Annals of Occupational Hygiene 32:65-70.
22. Mercer RM, Michael LR, James DC. 1991. Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. Health Physics 61:117-130.
23. Mercer RR, Michael LR, Roggoli VL, James DC. 1994. Cell number and distribution in human and rat airway. American Journal of Respiratory Cell and Molecular Biology 10:613-624.
24. 222Rn D.P. Radiation Research 152:S137-140.
25. Nikezic D, Haque AKMM, Yu KN. 2002. Absorbed dose delivered by alpha particles calculated in cylindrical geometry. Journal of Environmental Radioactivity 60:293-305.
26. NRC. 1991. Comparative dosimetry of radon in homes and mines. Washington DC: National Academy Press.
27. NRC. 1999. Health effects of exposure to radon. Committee on Health Risks of Exposure to Radon, BEIR VI Report 1999. Washington DC: National Academy Press.
28. Oldham MJ, Phalen RF, Heistracher T. 2000. Computational fluid dynamic predictions and experimental results for particle deposition in an airway model. Aerosol Science and Technology 32:61-71.
29. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramato A, Kamada N, Dohy H, Matsuo T, Mabuchi K. 1994. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma. pp 1950-1987. Radiation Research 137(2 Suppl.):S68-97.
30. Raabe OG, Yeh HC, Schum GM, Phalen RF. 1976. Tracheobronchial geometry: Human, dog, rat, hamster, LF-53 (Lovelace Foundation Report). New Mexico.
31. Reineking A, Becker KH, Porstendörfer J. 1988. Measurements of activity size distributions of the short-lived radon daughters in the indoor and outdoor environment. Radiation Protection Dosimetry 24:245-250.
32. Samet JM, Pathak DR, Morgan MV, Marbury MC, Key CR, Valdivia AA. 1989. Radon progeny exposure and lung cancer risk in New Mexico uranium miners: A case-control study. Health Physics 56:415-421.
33. Schlesinger RB, Lippmann M. 1978. Selective particle deposition and bronchogenic carcinoma. Environmental Research 15:424-431.
34. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). 2000. Source and effects of ionizing radiation. Report 2000 to the general assembly. New York: United Nations Scientific Committee on the Effects of Atomic Radiation.