Analysis of radon-induced lung cancer risk by a stochastic state-vector model of radiation carcinogenesis

Journal of Radiological Protection

Volumn 22, Issue 3 A, 2002, Pages

  Crawford Brown, Douglas J ^a   Hofmann, Werner ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; IRRADIATION; RADON; TUMORS; URANIUM;

CELLULAR TRANSITIONS;

RADIOLOGY;

DNA; RADON;

BIOLOGICAL MODEL; CANCER INCIDENCE; CANCER RISK; CELL ACTIVITY; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL STIMULATION; CELL TRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; CZECHOSLOVAKIA; DNA REPAIR; DNA STRAND BREAKAGE; EPIDEMIOLOGICAL DATA; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VIVO STUDY; IRRADIATION; LUNG; LUNG CANCER; MINER; MITOSIS; MONTE CARLO METHOD; NONLINEAR SYSTEM; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SIMULATION; STOCHASTIC MODEL; URANIUM MINE;

EID: 0036742047     PISSN: 09524746     EISSN: None     Source Type: Journal    
DOI: 10.1088/0952-4746/22/3A/323     Document Type: Conference Paper

References (9)

1. Crawford-Brown D J and Hofmann W 1990 A generalized state-vector model for radiation-induced cellular transformation Int. J. Radiat. Biol. 57 407-23
2. Crawford-Brown D J and Hofmann W 1993 Extension of a generalized state-vector model of radiation carcinogenesis to consideration of dose-rate Math. Biosci. 115 123-44
3. Crawford-Brown D J and Hofmann W 1996 The testing of radiobiological models of radon carcinogenesis for in vitro to in vivo extrapolations Environ. Int. 22 (Suppl 1) S985-94
4. International Commission on Radiological Protection (ICRP) 1993 Protection against radon-222 at home and at work ICRP Publication 65 Ann. ICRP vol 23 (Oxford: Pergamon)
5. Kunz E, Sevc J, Placek V and Horacek J 1979 Lung cancer in man in relation to different time distributions of radiation exposure Health Phys. 36 699-721
6. Miller R, Marino S, Brenner D, Martin S, Richards M, Rander-Pehrson G and Hall E 1995 The biological effectiveness of radon progeny alpha particles. II. Oncogenic transformation as a function of linear energy transfer Radiat. Res. 142 54-60
7. Schöllnberger H, Kotecki M R, Crawford-Brown D J, Hofmann W and Eckl P M 1999 Adaptive response and dose-response plateaus for initiation in a state-vector model of carcinogenesis Int. J. Radiat. Biol. 75 351-64
8. Schöllnberger H, Mebust M R, Crawford-Brown D J, Eckl P M and Hofmann W 2001 The significance of cell-cycle delay, multiple initiation pathways, misrepair, and replication errors in a model of radiobiological effects Int. J. Radiat. Biol. 77 519-27
9. Winkler-Heil R and Hofmann W 2002 Comparison of modeling concepts for radon progeny lung dosimetry High Levels of Natural Radiation and Radon Areas: Radiation Dose and Health Effects ed W Burkart, M Sohrabi and A Bayer (Amsterdam: Elsevier) at press