Mitochondrial uncoupling protein 2 mediates temperature heterogeneity in atherosclerotic plaques

Cardiovascular Research

Volumn 77, Issue 2, 2008, Pages 425-431

  Van De Parre, Tim J L ^a   Martinet, Wim ^a   Verheye, Stefan ^b   Kockx, Mark M ^b   Van Langenhove, Glenn ^b   Herman, Arnold G ^a   De Meyer, Guido R Y ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

Author keywords

Atherosclerosis; Macrophages; Mitochondria

Indexed keywords

SODIUM CYANIDE; UNCOUPLING PROTEIN 2;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BROWN ADIPOSE TISSUE; CATHETER; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; EX VIVO STUDY; HEART MITOCHONDRION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SUBENDOTHELIUM; TEMPERATURE; THERMOGENESIS; THERMOGRAPHY; THERMOMETER; THORACIC AORTA; WESTERN BLOTTING;

ANIMALS; ATHEROSCLEROSIS; CELLS, CULTURED; HUMANS; ION CHANNELS; MACROPHAGES; MALE; MICE; MITOCHONDRIAL PROTEINS; RABBITS; RNA, MESSENGER; THERMOGENESIS; THERMOGRAPHY;

EID: 38849143193     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvm003     Document Type: Article

References (30)

1. Madjid M, Zarrabi A, Litovsky S, Willerson JT, Casscells W. Finding vulnerable atherosclerotic plaques: is it worth the effort? Arterioscler Thromb Vasc Biol 2004;24:1775-1782.
2. Stefanadis C, Diamantopoulos L, Vlachopoulos C, Tsiamis E, Dernellis J, Toutouzas K, Stefanadi E, Toutouzas P. Thermal heterogeneity within human atherosclerotic coronary arteries detected in vivo - a new method of detection by application of a special thermography catheter. Circulation 1999; 99:1965-1971.
3. Stefanadis C, Diamandopoulos L, Dernellis J, Economou E, Tsiamis E, Toutouzas K, Vlachopoulos C, Toutouzas P. Heat production of atherosclerotic plaques and in.ammation assessed by the acute phase proteins in acute coronary syndromes. J Am Coll Cardiol 2000;35:358A-359A.
4. Casscells W, Hathorn B, David M, Krabach T, Vaughn WK, McAllister HA, Bearman G, Willerson JT. Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis. Lancet 1996;347:1447-1451.
5. Naghavi M, Madjid M, Gul K, Siadaty MS, Litovsky S, Willerson JT, Casscells SW. Thermography basket catheter: in vivo measurement of the temperature of atherosclerotic plaques for detection of vulnerable plaques. Catheter Cardiovasc Interv 2003;59:52-59.
6. Verheye S, De Meyer GRY, Van Langenhove G, Knaapen MW, Kockx MM. In vivo temperature heterogeneity of atherosclerotic plaques is determined by plaque composition. Circulation 2002;105:1596-1601.
7. Toutouzas K, Markou V, Drakopoulou M, Mitropoulos I, Tsiamis E, Vavuranakis M, Vaina S, Stefanadis C. Increased heat generation from atherosclerotic plaques in patients with type 2 diabetes: an increased local in.ammatory activation. Diabetes Care 2005;28:1656-1661.
8. Toutouzas K, Drakopoulou M, Mitropoulos J, Tsiamis E, Vaina S, Vavuranakis M, Markou V, Bosinakou E, Stefanadis C. Elevated plaque temperature in non-culprit de novo atheromatous lesions of patients with acute coronary syndromes. J Am Coll Cardiol 2006;47:301-306.
9. Argyropoulos G, Harper ME. Uncoupling proteins and thermoregulation. J Appl Physiol 2002;92:2187-2198.
10. Nubel T, Ricquier D. Respiration under control of uncoupling proteins: Clinical perspective. Horm Res 2006;65:300-310.
11. Mattiasson G, Sullivan PG. The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid Redox Signal 2006;8:1-38.
12. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 2005;6:248-261.
13. Echtay KS, Winkler E, Bienengraeber M, Klingenberg M. Site-directed mutagenesis identi.es residues in uncoupling protein (UCP1) involved in three different functions. Biochemistry 2000;39:3311-3317.
14. Martinet W, De Meyer GRY, Timmermans JP, Herman AG, Kockx MM. Macrophages but not smooth muscle cells undergo benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethylketone-induced nonapoptotic cell death depending on receptor-interacting protein 1 expression: implications for the stabilization of macrophage-rich atherosclerotic plaques. J Pharmacol Exp Ther 2006;317:1356-1364.
15. Martinet W, Schrijvers DM, De Meyer GRY, Thielemans J, Knaapen MW, Herman AG, Kockx MM. Gene expression pro.ling of apoptosis-related genes in human atherosclerosis: upregulation of death-associated protein kinase. Arterioscler Thromb Vasc Biol 2002;22:2023-2029.
16. Pecqueur C, Alves-Guerra MC, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F, Miroux B. Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem 2001;276:8705-8712.
17. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000;26:435-439.
18. Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J Neurosci 1999;19:10417-10427.
19. Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol 2003;65:1917-1921.
20. Paulik MA, Buckholz RG, Lancaster ME, Dallas WS, Hull-Ryde EA, Weiel JE, Lenhard JM. Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists. Pharm Res 1998;15:944-949.
21. Van De Parre TJL, Martinet W, Schrijvers DM, Herman AG, De Meyer GRY. MRNA but not plasmid DNA is ef.ciently transfected in murine J774A.1 macrophages. Biochem Biophys Res Commun 2005;327:356-360.
22. Van De Parre TJL, Martinet W, De Meyer GRY. mRNA transfection in monocytes and macrophages. In: Kwang LB, ed. New Messenger RNA Research Communications. Nova Science Publishers, Inc.; 2007:181-190.
23. Duval C, Negre-Salvayre A, Doglio A, Salvayre R, Penicaud L, Casteilla L. Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem Cell Biol Biochim Biol Cell 2002;80:757-764.
24. Ryu JW, Hong KH, Maeng JH, Kim JB, Ko J, Park JY, Lee KU, Hong MK, Park SW, Kim YH, Han KH. Overexpression of uncoupling protein 2 in THP1 monocytes inhibits beta2 integrin-mediated .rm adhesion and transendothelial migration. Arterioscler Thromb Vasc Biol 2004;24:864-870.
25. Lee KU, Lee IK, Han J, Song DK, Kim YM, Song HS, Kim HS, Lee WJ, Koh EH, Song KH, Han SM, Kim MS, Park IS, Park JY. Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circ Res 2005;96:1200-1207.
26. Blanc J, Alves-Guerra MC, Esposito B, Rousset S, Gourdy P, Ricquier D, Tedgui A, Miroux B, Mallat Z. Protective role of uncoupling protein 2 in atherosclerosis. Circulation 2003;107:388-390.
27. Oberko.er H, Iglseder B, Klein K, Unger J, Haltmayer M, Krempler F, Paulweber B, Patsch W. Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol 2005;25:1-7.
28. Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, Miller GJ, Humphries SE, Hurel SJ, Montogomery HE. Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. Eur Heart J 2004;25:468-475.
29. Casscells SW, Lal BN, Madjid M, Tewatia T, Aboshady I, Geng Y, Willerson JT. Thermal stabilization of vulnerable plaques. In: Virmani R, Narula J, Leon MB, Willerson JT, eds. The Vulnerable Atherosclerotic Plaque: Strategies for Diagnosis and Management. Blackwell Publishing; 2007. 331-342.
30. Schrijvers DM, De Meyer GRY, Kockx MM, Herman AG, Martinet W. Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis. Arterioscler Thromb Vasc Biol 2005;25:1256-1261.