Oestrogen receptor gene variation is a determinant of coronary reactivity in healthy young men

European Journal of Clinical Investigation

Volumn 32, Issue 6, 2002, Pages 400-404

  Lehtimaki T ^a   Laaksonen, R ^a,c   Mattila, K M ^a   Janatuinen, T ^b   Vesalainen, R ^b   Nuutila, P ^b   Laakso, J ^c   Jaakkola, O ^a   Koivula, T ^a   Knuuti, J ^b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Atherosclerosis; Coronary flow reserve; Endothelial dysfunction; Oestrogen receptor 1; Polymorphism; Positron emission tomography

Indexed keywords

AUTOANTIBODY; CHOLESTEROL; ESTROGEN RECEPTOR; LOW DENSITY LIPOPROTEIN;

ADULT; ANTIBODY TITER; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NORMAL HUMAN; OXIDATION; PATHOGENESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADULT; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGY; CHOLESTEROL; CORONARY CIRCULATION; ESTROGEN RECEPTOR ALPHA; GENOTYPE; HUMANS; LIPOPROTEINS; MALE; OXIDATION-REDUCTION; POLYMORPHISM, GENETIC; RECEPTORS, ESTROGEN; TOMOGRAPHY, EMISSION-COMPUTED; TRIGLYCERIDES; VARIATION (GENETICS);

EID: 0037002862     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2002.01010.x     Document Type: Article

References (32)

1. Clarkson P, Celermajer DS, Powe AJ, Donald AE, Henry RM, Deanfield JE. Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. Circulation 1997;96:3378-83.
2. Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. Circulation 1994;90:808-17.
3. Pitkanen OP, Raitakari OT, Ronnemaa T, Niinikoski H, Nuutila P, Iida Het al. Influence of cardiovascular risk status on coronary flow reserve in healthy young men. Am J Cardiol 1997;79:1690-2.
4. Pitkanen OP, Nuutila P, Raitakari OT, Ronnemaa T, Koskinen PJ, Iida H et al. Coronary flow reserve is reduced in young men with IDDM. Diabetes 1998;47:248-54.
5. Heitzer T, Yla-Herttuala S, Luoma J, Kurz S, Munzel T, Just Het al. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation 1996;93:1346-53.
6. Laine H, Raitakari OT, Niinikoski H, Pitkanen OP, Iida H, Viikari J et al. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol 1998;32:147-53.
7. Pitkanen OP, Raitakari OT, Niinikoski H, Nuutila P, Iida H, Voipio-Pulkki LM et al. Coronary flow reserve is impaired in young men with familial hypercholesterolemia. J Am Coll Cardiol 1996;28:1705-11.
8. Pitkanen OP, Nuutila P, Raitakari OT, Porkka K, Iida H, Nuotio Iet al. Coronary flow reserve in young men with familial combined hyperlipidemia. Circulation 1999;99:1678-84.
9. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801-11.
10. Yaich L, Dupont WD, Cavener DR, Parl FF. Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 1992;52:77-83.
11. Maruyama H, Toji H, Harrington CR, Sasaki K, Izumi Y, Ohnuma Tet al. Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease. Arch Neurol 2000;57:236-40.
12. Fan Y, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Koivula T et al. Hepatic lipase gene variation is related to coronary reactivity in healthy young men. Eur J Clin Invest 2001;31:574-80.
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
14. Markwell MAK, Hass SM, Tolbert NE, Bieber LL. Protein determination in mebrane and lipoprotein samples manual and automatic procerudes. Meth Enzymol 1981;123:293-303.
15. Laaksonen R, Riihimaki A, Laitila J, Martensson K, Tikkanen MJ, Himberg JJ. Serum and muscle tissue ubiquinone levels in healthy subjects. J Laboratory Clin Med 1995;125:517-21.
16. Lehtimaki T, Lehtinen S, Solakivi T, Nikkila M, Jaakkola O, Jokela Het al. Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease. Arterioscler Thromb Vasc Biol 1999;19:23-7.
17. Mattila KM, Axelman K, Rinne JO, Blomberg M, Lehtimaki T, Laippala P et al. Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women. Neurosci Lett 2000;282:45-8.
18. Arnal JF, Clamens S, Pechet C, Negre-Salvayre A, Allera C, Girolami JPet al. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci USA 1996;93:4108-13.
19. Binko J, Majewski H. 17 beta-Estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS. Am J Physiol 1998;274:H853-9.
20. Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 1986;250:H822-7.
21. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 1994;91:5212-6.
22. Sugioka K, Shimosegawa Y, Nakano M. Estrogens as natural antioxidants of membrane phospholipid peroxidation. FEBS Lett 1987;210:37-9.
23. Liehr JG. Antioxidant and prooxidant properties of estrogens. J Laboratory Clin Med 1996;128:344-5.
24. Shwaery GT, Vita JA, Keaney JF Jr. Antioxidant protection of LDL by physiological concentrations of 17 beta-estradiol. Requirement for estradiol modification. Circulation 1997;95:1378-85.
25. Santanam N, Shern-Brewer R, McClatchey R, Castellano PZ, Murphy AA, Voelkel S et al. Estradiol as an antioxidant: incompatible with its physiological concentrations and function.J Lipid Res 1998;39:2111-8.
26. Sack MN, Rader DJ, Cannon RO 3rd. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994;343:269-70.
27. Karas RH, Patterson BL, Mendelsohn ME. Human vascular smooth muscle cells contain functional estrogen receptor. Circulation 1994;89:1943-50.
28. Losordo DW, Kearney M, Kim EA, Jekanowski J, Isner JM. Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation 1994;89:1501-10.
29. Venkov CD, Rankin AB, Vaughan DE. Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation 1996;94:727-33.
30. Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. J Clin Invest 1986;77:757-61.
31. Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987;262:10098-103.
32. Parthasarathy S. Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor. Biochim Biophys Acta 1987;917:337-40.