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Volumn 38, Issue 1, 2008, Pages 167-178

Oxidative Stress, Aging, and Central Nervous System Disease in the Canine Model of Human Brain Aging

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BRAIN PROTEIN; CANTHAXANTHIN; CARNITINE; CAROTENOID; COPPER; DOCOSAHEXAENOIC ACID; FREE RADICAL; ICOSAPENTAENOIC ACID; LIPID; MANGANESE; NUTRACEUTICAL; RETINOL; SELENIUM; SUPEROXIDE DISMUTASE; THIOCTIC ACID; ZINC;

EID: 38749153965     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2007.10.002     Document Type: Review
Times cited : (55)

References (62)
  • 2
    • 17144436887 scopus 로고    scopus 로고
    • Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog
    • Adams B., Chan A., Callahan H., et al. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res 108 1 (2000) 47-56
    • (2000) Behav Brain Res , vol.108 , Issue.1 , pp. 47-56
    • Adams, B.1    Chan, A.2    Callahan, H.3
  • 3
    • 0035999629 scopus 로고    scopus 로고
    • Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility
    • Chan A.D., Nippak P.M., Murphey H., et al. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci 116 3 (2002) 443-454
    • (2002) Behav Neurosci , vol.116 , Issue.3 , pp. 443-454
    • Chan, A.D.1    Nippak, P.M.2    Murphey, H.3
  • 4
    • 0028784660 scopus 로고
    • Spatial learning and memory as a function of age in the dog
    • Head E., Mehta R., Hartley J., et al. Spatial learning and memory as a function of age in the dog. Behav Neurosci 109 (1995) 851-858
    • (1995) Behav Neurosci , vol.109 , pp. 851-858
    • Head, E.1    Mehta, R.2    Hartley, J.3
  • 5
    • 0028331373 scopus 로고
    • Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks
    • Milgram N.W., Head E., Weiner E., et al. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behav Neurosci 108 (1994) 57-68
    • (1994) Behav Neurosci , vol.108 , pp. 57-68
    • Milgram, N.W.1    Head, E.2    Weiner, E.3
  • 6
    • 0034257957 scopus 로고    scopus 로고
    • Vascular and parenchymal Ab deposition in the aging dog: correlation with behavior
    • Colle M.-A., Hauw J.-J., Crespeau F., et al. Vascular and parenchymal Ab deposition in the aging dog: correlation with behavior. Neurobiol Aging 21 (2000) 695-704
    • (2000) Neurobiol Aging , vol.21 , pp. 695-704
    • Colle, M.-A.1    Hauw, J.-J.2    Crespeau, F.3
  • 7
    • 31344454617 scopus 로고    scopus 로고
    • Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease
    • Rofina J.E., van Ederen A.M., Toussaint M.J., et al. Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069 1 (2006) 216-226
    • (2006) Brain Res , vol.1069 , Issue.1 , pp. 216-226
    • Rofina, J.E.1    van Ederen, A.M.2    Toussaint, M.J.3
  • 8
    • 0029564645 scopus 로고
    • Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to l-deprenyl therapy
    • Ruehl W.W., Bruyette D.S., DePaoli A., et al. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to l-deprenyl therapy. Prog Brain Res 106 (1995) 217-225
    • (1995) Prog Brain Res , vol.106 , pp. 217-225
    • Ruehl, W.W.1    Bruyette, D.S.2    DePaoli, A.3
  • 10
    • 0035406946 scopus 로고    scopus 로고
    • Effect of gonadectomy on subsequent development of age-related cognitive impairment in dogs
    • Hart B.L. Effect of gonadectomy on subsequent development of age-related cognitive impairment in dogs. J Am Vet Med Assoc 219 1 (2001) 51-56
    • (2001) J Am Vet Med Assoc , vol.219 , Issue.1 , pp. 51-56
    • Hart, B.L.1
  • 11
    • 0035377333 scopus 로고    scopus 로고
    • Prevalence of behavioral changes associated with age-related cognitive impairment in dogs
    • Neilson J.C., Hart B.L., Cliff K.D., et al. Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. J Am Vet Med Assoc 218 11 (2001) 1787-1791
    • (2001) J Am Vet Med Assoc , vol.218 , Issue.11 , pp. 1787-1791
    • Neilson, J.C.1    Hart, B.L.2    Cliff, K.D.3
  • 13
    • 0036751980 scopus 로고    scopus 로고
    • Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
    • Cotman C.W., Head E., Muggenburg B.A., et al. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging 23 5 (2002) 809-818
    • (2002) Neurobiol Aging , vol.23 , Issue.5 , pp. 809-818
    • Cotman, C.W.1    Head, E.2    Muggenburg, B.A.3
  • 14
    • 0029937437 scopus 로고    scopus 로고
    • The canine as an animal model of human aging and dementia
    • Cummings B.J., Head E., Ruehl W.W., et al. The canine as an animal model of human aging and dementia. Neurobiol Aging 17 (1996) 259-268
    • (1996) Neurobiol Aging , vol.17 , pp. 259-268
    • Cummings, B.J.1    Head, E.2    Ruehl, W.W.3
  • 15
    • 0003164396 scopus 로고    scopus 로고
    • Neurobiological models of aging in the dog and other vertebrate species
    • Hof P., and Mobbs C. (Eds), Academic Press, San Diego
    • Head E., Milgram N.W., and Cotman C.W. Neurobiological models of aging in the dog and other vertebrate species. In: Hof P., and Mobbs C. (Eds). Functional neurobiology of aging (2001), Academic Press, San Diego 457-468
    • (2001) Functional neurobiology of aging , pp. 457-468
    • Head, E.1    Milgram, N.W.2    Cotman, C.W.3
  • 16
    • 0001579029 scopus 로고
    • Aged dogs: an animal model to study beta-protein amyloidogenesis
    • Maurer K., Riederer P., and Beckman H. (Eds), Springer-Verlag, New York
    • Wisniewski H.M., Wegiel J., Morys J., et al. Aged dogs: an animal model to study beta-protein amyloidogenesis. In: Maurer K., Riederer P., and Beckman H. (Eds). Alzheimer's disease. Epidemiology, neuropathology, neurochemistry and clinics (1990), Springer-Verlag, New York 151-167
    • (1990) Alzheimer's disease. Epidemiology, neuropathology, neurochemistry and clinics , pp. 151-167
    • Wisniewski, H.M.1    Wegiel, J.2    Morys, J.3
  • 17
    • 0033125493 scopus 로고    scopus 로고
    • Age-related changes in the brain of the dog
    • Borras D., Ferrer I., and Pumarola M. Age-related changes in the brain of the dog. Vet Pathol 36 3 (1999) 202-211
    • (1999) Vet Pathol , vol.36 , Issue.3 , pp. 202-211
    • Borras, D.1    Ferrer, I.2    Pumarola, M.3
  • 18
    • 33847760962 scopus 로고    scopus 로고
    • The canine model of human brain aging: cognition, behavior and neuropathology
    • Conn P.M. (Ed), Elsevier Inc., Burlington (MA)
    • Tapp P.D., and Siwak C. The canine model of human brain aging: cognition, behavior and neuropathology. In: Conn P.M. (Ed). Handbook of models of human aging (2006), Elsevier Inc., Burlington (MA) 415-434
    • (2006) Handbook of models of human aging , pp. 415-434
    • Tapp, P.D.1    Siwak, C.2
  • 19
    • 0032440880 scopus 로고    scopus 로고
    • MR imaging of anatomic and vascular characteristics in a canine model of human aging
    • Su M.-Y., Head E., Brooks W.M., et al. MR imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging 19 5 (1998) 479-485
    • (1998) Neurobiol Aging , vol.19 , Issue.5 , pp. 479-485
    • Su, M.-Y.1    Head, E.2    Brooks, W.M.3
  • 20
    • 27744493338 scopus 로고    scopus 로고
    • Changes of magnetic resonance imaging on the brain in beagle dogs with aging
    • Kimotsuki T., Nagaoka T., Yasuda M., et al. Changes of magnetic resonance imaging on the brain in beagle dogs with aging. J Vet Med Sci 67 10 (2005) 961-967
    • (2005) J Vet Med Sci , vol.67 , Issue.10 , pp. 961-967
    • Kimotsuki, T.1    Nagaoka, T.2    Yasuda, M.3
  • 21
    • 17144461264 scopus 로고    scopus 로고
    • Age-related changes in the ventricular system of the dog brain
    • Gonzalez-Soriano J., Marin Garcia P., Contreras-Rodriguez J., et al. Age-related changes in the ventricular system of the dog brain. Ann Anat 183 3 (2001) 283-291
    • (2001) Ann Anat , vol.183 , Issue.3 , pp. 283-291
    • Gonzalez-Soriano, J.1    Marin Garcia, P.2    Contreras-Rodriguez, J.3
  • 22
    • 4644343710 scopus 로고    scopus 로고
    • Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging
    • Tapp P.D., Siwak C.T., Gao F.Q., et al. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci 24 38 (2004) 8205-8213
    • (2004) J Neurosci , vol.24 , Issue.38 , pp. 8205-8213
    • Tapp, P.D.1    Siwak, C.T.2    Gao, F.Q.3
  • 23
    • 19944426233 scopus 로고    scopus 로고
    • White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    • Du A.T., Schuff N., Chao L.L., et al. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging 26 4 (2005) 553-559
    • (2005) Neurobiol Aging , vol.26 , Issue.4 , pp. 553-559
    • Du, A.T.1    Schuff, N.2    Chao, L.L.3
  • 24
    • 19944425940 scopus 로고    scopus 로고
    • Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: boundary shift integral versus tracing of the entorhinal cortex and hippocampus
    • Ezekiel F., Chao L., Kornak J., et al. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: boundary shift integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord 18 4 (2004) 196-201
    • (2004) Alzheimer Dis Assoc Disord , vol.18 , Issue.4 , pp. 196-201
    • Ezekiel, F.1    Chao, L.2    Kornak, J.3
  • 25
    • 0000461567 scopus 로고
    • Kongophile angiopathie und senile plaques bei greisen hunden
    • Braunmuhl A. Kongophile angiopathie und senile plaques bei greisen hunden. Arch Psychiatr Nervenkr 194 (1956) 395-414
    • (1956) Arch Psychiatr Nervenkr , vol.194 , pp. 395-414
    • Braunmuhl, A.1
  • 26
    • 0342621746 scopus 로고
    • Neoformaciones dendriticas an las neuronas y alteraciones de la neuroglia en el perro senil
    • Lafora G. Neoformaciones dendriticas an las neuronas y alteraciones de la neuroglia en el perro senil. Trab del Lab de Investig biol t.12: fasc. 1 (1914)
    • (1914) Trab del Lab de Investig biol t.12: fasc. 1
    • Lafora, G.1
  • 27
    • 0014848353 scopus 로고
    • Senile plaques and cerebral amyloidosis in aged dogs
    • Wisniewski H.M., Johnson A.B., Raine C.S., et al. Senile plaques and cerebral amyloidosis in aged dogs. Lab Invest 23 (1970) 287-296
    • (1970) Lab Invest , vol.23 , pp. 287-296
    • Wisniewski, H.M.1    Johnson, A.B.2    Raine, C.S.3
  • 28
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid beta-protein and the genetics of Alzheimer's disease
    • Selkoe D.J. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271 (1996) 18295-18298
    • (1996) J Biol Chem , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 29
    • 0025853543 scopus 로고
    • Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis
    • Johnstone E.M., Chaney M.O., Norris F.H., et al. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain Res Mol Brain Res 10 4 (1991) 299-305
    • (1991) Brain Res Mol Brain Res , vol.10 , Issue.4 , pp. 299-305
    • Johnstone, E.M.1    Chaney, M.O.2    Norris, F.H.3
  • 30
    • 0023118252 scopus 로고
    • Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease
    • Selkoe D.J., Bell D.S., Podlisny M.B., et al. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science 235 (1987) 873-877
    • (1987) Science , vol.235 , pp. 873-877
    • Selkoe, D.J.1    Bell, D.S.2    Podlisny, M.B.3
  • 31
    • 0027332522 scopus 로고
    • Beta-amyloid accumulation in aged canine brain: a model of plaque formation in Alzheimer's disease
    • Cummings B.J., Su J.H., Cotman C.W., et al. Beta-amyloid accumulation in aged canine brain: a model of plaque formation in Alzheimer's disease. Neurobiology of Aging 14 (1993) 547-560
    • (1993) Neurobiology of Aging , vol.14 , pp. 547-560
    • Cummings, B.J.1    Su, J.H.2    Cotman, C.W.3
  • 32
    • 0030952317 scopus 로고    scopus 로고
    • Distribution of beta-amyloid in the canine brain
    • Hou Y., White R.G., Bobik M., et al. Distribution of beta-amyloid in the canine brain. NeuroReport 8 (1997) 1009-1012
    • (1997) NeuroReport , vol.8 , pp. 1009-1012
    • Hou, Y.1    White, R.G.2    Bobik, M.3
  • 33
    • 0029992320 scopus 로고    scopus 로고
    • Age-specific onset of beta-amyloid in beagle brains
    • Russell M.J., Bobik M., White R.G., et al. Age-specific onset of beta-amyloid in beagle brains. Neurobiol Aging 17 (1996) 269-273
    • (1996) Neurobiol Aging , vol.17 , pp. 269-273
    • Russell, M.J.1    Bobik, M.2    White, R.G.3
  • 34
    • 0029978976 scopus 로고    scopus 로고
    • Carboxy terminal of beta-amyloid deposits in aged human, canine and polar bear brains
    • Tekirian T.L., Cole G.M., Russell M.J., et al. Carboxy terminal of beta-amyloid deposits in aged human, canine and polar bear brains. Neurobiol Aging 17 (1996) 249-257
    • (1996) Neurobiol Aging , vol.17 , pp. 249-257
    • Tekirian, T.L.1    Cole, G.M.2    Russell, M.J.3
  • 35
    • 0030013083 scopus 로고    scopus 로고
    • Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine
    • Cummings B.J., Head E., Afagh A.J., et al. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem 66 1 (1996) 11-23
    • (1996) Neurobiol Learn Mem , vol.66 , Issue.1 , pp. 11-23
    • Cummings, B.J.1    Head, E.2    Afagh, A.J.3
  • 36
    • 0032410562 scopus 로고    scopus 로고
    • Visual-discrimination learning ability and beta-amyloid accumulation in the dog
    • Head E., Callahan H., Muggenburg B.A., et al. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging 19 5 (1998) 415-425
    • (1998) Neurobiol Aging , vol.19 , Issue.5 , pp. 415-425
    • Head, E.1    Callahan, H.2    Muggenburg, B.A.3
  • 37
    • 0042703651 scopus 로고    scopus 로고
    • Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages
    • Rofina J., van Andel I., van Ederen A.M., et al. Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10 2 (2003) 86-96
    • (2003) Amyloid , vol.10 , Issue.2 , pp. 86-96
    • Rofina, J.1    van Andel, I.2    van Ederen, A.M.3
  • 38
    • 4544285567 scopus 로고    scopus 로고
    • Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine
    • Rofina J.E., Singh K., Skoumalova-Vesela A., et al. Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid 11 2 (2004) 90-100
    • (2004) Amyloid , vol.11 , Issue.2 , pp. 90-100
    • Rofina, J.E.1    Singh, K.2    Skoumalova-Vesela, A.3
  • 39
    • 0031475121 scopus 로고    scopus 로고
    • Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain
    • Kiatipattanasakul W., Nakamura S., Kuroki K., et al. Immunohistochemical detection of anti-oxidative stress enzymes in the dog brain. Neuropathology 17 (1997) 307-312
    • (1997) Neuropathology , vol.17 , pp. 307-312
    • Kiatipattanasakul, W.1    Nakamura, S.2    Kuroki, K.3
  • 40
    • 0036069450 scopus 로고    scopus 로고
    • Oxidative damage increases with age in a canine model of human brain aging
    • Head E., Liu J., Hagen T.M., et al. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem 82 (2002) 375-381
    • (2002) J Neurochem , vol.82 , pp. 375-381
    • Head, E.1    Liu, J.2    Hagen, T.M.3
  • 41
    • 0038580535 scopus 로고    scopus 로고
    • The role of free radicals in canine counterpart of senile dementia of the Alzheimer type
    • Skoumalova A., Rofina J., Schwippelova Z., et al. The role of free radicals in canine counterpart of senile dementia of the Alzheimer type. Exp Gerontol 38 6 (2003) 711-719
    • (2003) Exp Gerontol , vol.38 , Issue.6 , pp. 711-719
    • Skoumalova, A.1    Rofina, J.2    Schwippelova, Z.3
  • 42
    • 0035093896 scopus 로고    scopus 로고
    • Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques
    • Papaioannou N., Tooten P.C., van Ederen A.M., et al. Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. Amyloid 8 1 (2001) 11-21
    • (2001) Amyloid , vol.8 , Issue.1 , pp. 11-21
    • Papaioannou, N.1    Tooten, P.C.2    van Ederen, A.M.3
  • 43
    • 3042662696 scopus 로고    scopus 로고
    • Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease
    • Bartzokis G., Sultzer D., Lu P.H., et al. Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease. Neurobiol Aging 25 7 (2004) 843-851
    • (2004) Neurobiol Aging , vol.25 , Issue.7 , pp. 843-851
    • Bartzokis, G.1    Sultzer, D.2    Lu, P.H.3
  • 44
    • 0842325638 scopus 로고    scopus 로고
    • White matter lesions and hippocampal atrophy in Alzheimer's disease
    • de Leeuw F.E., Barkhof F., and Scheltens P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 62 2 (2004) 310-312
    • (2004) Neurology , vol.62 , Issue.2 , pp. 310-312
    • de Leeuw, F.E.1    Barkhof, F.2    Scheltens, P.3
  • 45
    • 0038077245 scopus 로고    scopus 로고
    • Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells
    • Munch G., Gasic-Milenkovic J., Dukic-Stefanovic S., et al. Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells. Exp Brain Res 150 1 (2003) 1-8
    • (2003) Exp Brain Res , vol.150 , Issue.1 , pp. 1-8
    • Munch, G.1    Gasic-Milenkovic, J.2    Dukic-Stefanovic, S.3
  • 46
    • 0035690720 scopus 로고    scopus 로고
    • Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins
    • Meda L., Baron P., and Scarlato G. Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins. Neurobiol Aging 22 6 (2001) 885-893
    • (2001) Neurobiol Aging , vol.22 , Issue.6 , pp. 885-893
    • Meda, L.1    Baron, P.2    Scarlato, G.3
  • 47
    • 0028946146 scopus 로고
    • Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures
    • Del Bo R., Angeretti N., Lucca E., et al. Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures. Neurosci Lett 188 1 (1995) 70-74
    • (1995) Neurosci Lett , vol.188 , Issue.1 , pp. 70-74
    • Del Bo, R.1    Angeretti, N.2    Lucca, E.3
  • 48
    • 17844375420 scopus 로고    scopus 로고
    • Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice shows accelerated diffuse beta-amyloid deposition
    • Yamamoto M., Horiba M., Buescher J.L., et al. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice shows accelerated diffuse beta-amyloid deposition. Am J Pathol 166 5 (2005) 1475-1485
    • (2005) Am J Pathol , vol.166 , Issue.5 , pp. 1475-1485
    • Yamamoto, M.1    Horiba, M.2    Buescher, J.L.3
  • 49
    • 0035690976 scopus 로고    scopus 로고
    • Interleukin-1, neuroinflammation, and Alzheimer's disease
    • Mrak R.E., and Griffin W.S. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging 22 6 (2001) 903-908
    • (2001) Neurobiol Aging , vol.22 , Issue.6 , pp. 903-908
    • Mrak, R.E.1    Griffin, W.S.2
  • 50
    • 0029923520 scopus 로고    scopus 로고
    • Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals
    • Fukumoto H., Asami-Odaka A., Suzuki N., et al. Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration 5 1 (1996) 13-17
    • (1996) Neurodegeneration , vol.5 , Issue.1 , pp. 13-17
    • Fukumoto, H.1    Asami-Odaka, A.2    Suzuki, N.3
  • 51
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B.N., Shigenaga M.K., and Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90 (1993) 7915-7922
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 52
    • 0034237123 scopus 로고    scopus 로고
    • Nutritional antioxidants as antidegenerative agents
    • De Ruvo C., Amodio R., Algeri S., et al. Nutritional antioxidants as antidegenerative agents. Int J Dev Neurosci 18 4-5 (2000) 359-366
    • (2000) Int J Dev Neurosci , vol.18 , Issue.4-5 , pp. 359-366
    • De Ruvo, C.1    Amodio, R.2    Algeri, S.3
  • 53
    • 17744409780 scopus 로고    scopus 로고
    • Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion
    • Haramaki N., Stewart D.B., Aggarwal S., et al. Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion. Free Radic Biol Med 25 3 (1998) 329-339
    • (1998) Free Radic Biol Med , vol.25 , Issue.3 , pp. 329-339
    • Haramaki, N.1    Stewart, D.B.2    Aggarwal, S.3
  • 54
    • 0037133283 scopus 로고    scopus 로고
    • Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid
    • Liu J., Head E., Gharib A.M., et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A 99 4 (2002) 2356-2361
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.4 , pp. 2356-2361
    • Liu, J.1    Head, E.2    Gharib, A.M.3
  • 55
    • 0037133319 scopus 로고    scopus 로고
    • Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha-lipoic acid
    • Liu J., Killilea D.W., and Ames B.N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci U S A 99 4 (2002) 1876-1881
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.4 , pp. 1876-1881
    • Liu, J.1    Killilea, D.W.2    Ames, B.N.3
  • 56
    • 0036819096 scopus 로고    scopus 로고
    • Landmark discrimination learning in the dog: effects of age, an antioxidant fortified diet, and cognitive strategy
    • Milgram N.W., Head E., Muggenburg B.A., et al. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified diet, and cognitive strategy. Neurosci Biobehav Rev 26 6 (2002) 679-695
    • (2002) Neurosci Biobehav Rev , vol.26 , Issue.6 , pp. 679-695
    • Milgram, N.W.1    Head, E.2    Muggenburg, B.A.3
  • 57
    • 10044265541 scopus 로고    scopus 로고
    • Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study
    • Milgram N.W., Head E., Zicker S.C., et al. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging 26 (2005) 77-90
    • (2005) Neurobiol Aging , vol.26 , pp. 77-90
    • Milgram, N.W.1    Head, E.2    Zicker, S.C.3
  • 58
    • 36049026787 scopus 로고    scopus 로고
    • Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease
    • doi:10.1016/j.neurobiolaging.2006.09.012
    • Opii W.O., Joshi G., Head E., et al. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging (2006). doi:10.1016/j.neurobiolaging.2006.09.012
    • (2006) Neurobiol Aging
    • Opii, W.O.1    Joshi, G.2    Head, E.3
  • 61
    • 26344464628 scopus 로고    scopus 로고
    • Improved vitamin E bioavailability from a fortified breakfast cereal as compared with a vitamin E supplement
    • Leonard S.W., Good C., Guggar E., et al. Improved vitamin E bioavailability from a fortified breakfast cereal as compared with a vitamin E supplement. FASEB J 16 4 (2002) A373-A374
    • (2002) FASEB J , vol.16 , Issue.4
    • Leonard, S.W.1    Good, C.2    Guggar, E.3
  • 62
    • 0023788981 scopus 로고
    • Canthaxanthin-induced retinal pigment epithelial changes in the cat
    • Scallon L.J., Burke J.M., Mieler W.F., et al. Canthaxanthin-induced retinal pigment epithelial changes in the cat. Curr Eye Res 7 7 (1988) 687-693
    • (1988) Curr Eye Res , vol.7 , Issue.7 , pp. 687-693
    • Scallon, L.J.1    Burke, J.M.2    Mieler, W.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.