2D Autocorrelation, CoMFA, and CoMSIA modeling of protein tyrosine kinases' inhibition by substituted pyrido[2,3-d]pyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 810-821

  Caballero, Julio ^a   Fernández, Michael ^b   Saavedra, Mario ^a   González Nilo, Fernando D ^a  

^a UNIVERSIDAD DE TALCA   (Chile)

^b UNIVERSITY OF MATANZAS   (Cuba)

Author keywords

2D Autocorrelation space; CoMFA; CoMSIA; Protein tyrosine kinase inhibitors; QSAR analysis

Indexed keywords

BEVACIZUMAB; GEFITINIB; IMATINIB; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; TRASTUZUMAB;

ARTICLE; CHEMICAL BOND; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; COMPETITIVE INHIBITION; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DERIVATIZATION; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GENETIC ALGORITHM; HYDROPHOBICITY; MOLECULAR MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; PREDICTION; SUBSTITUTION REACTION;

ALGORITHMS; DRUG DESIGN; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASES; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SRC-FAMILY KINASES;

EID: 38749091306     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.024     Document Type: Article

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