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Volumn 375, Issue 4, 2007, Pages 273-281

A role for cyclooxygenase in aging-related changes of β-adrenoceptor- mediated relaxation in rat aortas

Author keywords

adrenoceptor; Age; Aorta; Cyclooxygenase; Endothelium; Prostacyclin

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; ISOPRENALINE; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE; PROSTANOID; THROMBOXANE A2; THROMBOXANE B2;

EID: 34247867979     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0153-y     Document Type: Article
Times cited : (15)

References (53)
  • 1
    • 0027930504 scopus 로고
    • Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension
    • Arribas S, Marin J, Ponte A, Balfagon G, Salaices M (1994) Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension. J Pharmacol Exp Ther 270:520-527
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 520-527
    • Arribas, S.1    Marin, J.2    Ponte, A.3    Balfagon, G.4    Salaices, M.5
  • 2
    • 0030759874 scopus 로고    scopus 로고
    • Impairment of vasodilator function in basilar arteries from aged rats
    • Arribas SM, Vila E, McGrath JC (1997) Impairment of vasodilator function in basilar arteries from aged rats. Stroke 28:1812-1820
    • (1997) Stroke , vol.28 , pp. 1812-1820
    • Arribas, S.M.1    Vila, E.2    McGrath, J.C.3
  • 3
    • 33744823282 scopus 로고    scopus 로고
    • Beta-adrenoceptor mediated responses in rat pulmonary artery: Putative role of TASK-1 related K channels
    • Bieger D, Parai K, Ford CA, Tabrizchi R (2006) Beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. Naunyn-Schmiedebergs Arch Pharmacol 373:186-196
    • (2006) Naunyn-Schmiedebergs Arch Pharmacol , vol.373 , pp. 186-196
    • Bieger, D.1    Parai, K.2    Ford, C.A.3    Tabrizchi, R.4
  • 4
    • 0030950128 scopus 로고    scopus 로고
    • Characterization of the induction of nitric oxide synthase and cyclo- oxygenase in rat aorta in organ culture
    • Bishop-Bailey D, Larkin SW, Warner TD, Chen G, Mitchell JA (1997) Characterization of the induction of nitric oxide synthase and cyclo- oxygenase in rat aorta in organ culture. Br J Pharmacol 121:125-133
    • (1997) Br J Pharmacol , vol.121 , pp. 125-133
    • Bishop-Bailey, D.1    Larkin, S.W.2    Warner, T.D.3    Chen, G.4    Mitchell, J.A.5
  • 6
    • 0026442829 scopus 로고
    • Vascular beta-adrenoceptor- mediated responses in hypertension and ageing in rats
    • Borkowski KR, Gros R, Schneider H (1992) Vascular beta-adrenoceptor- mediated responses in hypertension and ageing in rats. J Auton Pharmacol 12:389-401
    • (1992) J Auton Pharmacol , vol.12 , pp. 389-401
    • Borkowski, K.R.1    Gros, R.2    Schneider, H.3
  • 7
    • 26044445766 scopus 로고    scopus 로고
    • Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries
    • Briones AM, Montoya N, Giraldo J, Vila E (2005a) Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries. Auton Autacoid Pharmacol 25:155-162
    • (2005) Auton Autacoid Pharmacol , vol.25 , pp. 155-162
    • Briones, A.M.1    Montoya, N.2    Giraldo, J.3    Vila, E.4
  • 8
    • 18844439123 scopus 로고    scopus 로고
    • Ageing alters the production of nitric oxide and prostanoids after IL-1beta exposure in mesenteric resistance arteries
    • Briones AM, Salaices M, Vila E (2005b) Ageing alters the production of nitric oxide and prostanoids after IL-1beta exposure in mesenteric resistance arteries. Mech Ageing Dev 126:710-721
    • (2005) Mech Ageing Dev , vol.126 , pp. 710-721
    • Briones, A.M.1    Salaices, M.2    Vila, E.3
  • 9
    • 0019150484 scopus 로고
    • Age-related decrease in prostacyclin biosynthetic activity in rat aortic smooth muscle cells
    • Chang WC, Murota SI, Nakao J, Orimo H (1980) Age-related decrease in prostacyclin biosynthetic activity in rat aortic smooth muscle cells. Biochim Biophys Acta 620:159-166
    • (1980) Biochim Biophys Acta , vol.620 , pp. 159-166
    • Chang, W.C.1    Murota, S.I.2    Nakao, J.3    Orimo, H.4
  • 10
    • 0031595054 scopus 로고    scopus 로고
    • Evidence that Ca2+-activated K+ channels play a major role in mediating the vascular effects of iloprost and cicaprost
    • Clapp LH, Turcato S, Hall S, Baloch M (1998) Evidence that Ca2+-activated K+ channels play a major role in mediating the vascular effects of iloprost and cicaprost. Eur J Pharmacol 356:215-224
    • (1998) Eur J Pharmacol , vol.356 , pp. 215-224
    • Clapp, L.H.1    Turcato, S.2    Hall, S.3    Baloch, M.4
  • 11
    • 0019996073 scopus 로고
    • Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium
    • De Mey JG, Vanhoutte PM (1982) Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium. Circ Res 51:439-447
    • (1982) Circ Res , vol.51 , pp. 439-447
    • De Mey, J.G.1    Vanhoutte, P.M.2
  • 12
    • 0024409631 scopus 로고
    • Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age
    • Deisher TA, Mankani S, Hoffman BB (1989) Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age. J Pharmacol Exp Ther 249:812-819
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 812-819
    • Deisher, T.A.1    Mankani, S.2    Hoffman, B.B.3
  • 13
    • 0029816157 scopus 로고    scopus 로고
    • Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: Role of phosphodiesterase 3
    • Delpy E, Coste H, Gouville AC (1996) Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol 119:471-478
    • (1996) Br J Pharmacol , vol.119 , pp. 471-478
    • Delpy, E.1    Coste, H.2    Gouville, A.C.3
  • 14
    • 0026496905 scopus 로고
    • Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle
    • Dorn GW 2nd, Becker MW, Davis MG (1992) Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle. J Biol Chem 267:24897-24905
    • (1992) J Biol Chem , vol.267 , pp. 24897-24905
    • Dorn 2nd, G.W.1    Becker, M.W.2    Davis, M.G.3
  • 15
    • 1642303185 scopus 로고    scopus 로고
    • Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and beta-adrenergic renal vasodilations
    • El-Mas MM, Mohy El-Din MM, El-Gowilly SM, Sharabi FM (2004) Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and beta-adrenergic renal vasodilations. Eur J Pharmacol 487:149-158
    • (2004) Eur J Pharmacol , vol.487 , pp. 149-158
    • El-Mas, M.M.1    Mohy El-Din, M.M.2    El-Gowilly, S.M.3    Sharabi, F.M.4
  • 16
    • 0027391480 scopus 로고
    • Effect of aging and drug-induced weight reduction on rat vascular reactivity
    • Feletou M, Moreau N, Boulanger M, Duhault J (1993) Effect of aging and drug-induced weight reduction on rat vascular reactivity. J Cardiovasc Pharmacol 21:120-127
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 120-127
    • Feletou, M.1    Moreau, N.2    Boulanger, M.3    Duhault, J.4
  • 17
    • 0026567539 scopus 로고
    • Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man
    • Ford GA, Hoffman BB, Vestal RE, Blaschke TF (1992) Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man. Br J Clin Pharmacol 33:83-87
    • (1992) Br J Clin Pharmacol , vol.33 , pp. 83-87
    • Ford, G.A.1    Hoffman, B.B.2    Vestal, R.E.3    Blaschke, T.F.4
  • 18
    • 33745698250 scopus 로고    scopus 로고
    • Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder
    • Frazier EP, Schneider T, Michel MC (2006) Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder. Naunyn-Schmiedebergs Arch Pharmacol 373:300-309
    • (2006) Naunyn-Schmiedebergs Arch Pharmacol , vol.373 , pp. 300-309
    • Frazier, E.P.1    Schneider, T.2    Michel, M.C.3
  • 19
    • 0025922250 scopus 로고
    • Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N- ethylcarboxamidoadenosine or salbutamol in conscious rats
    • Gardiner SM, Kemp PA, Bennett T (1991) Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5′-N- ethylcarboxamidoadenosine or salbutamol in conscious rats. Br J Pharmacol 103:1725-1732
    • (1991) Br J Pharmacol , vol.103 , pp. 1725-1732
    • Gardiner, S.M.1    Kemp, P.A.2    Bennett, T.3
  • 20
    • 0022400757 scopus 로고
    • Platelets from aged rats aggregate more, but are more sensitive to prostacyclin
    • Giani E, Masi I, Galli C (1985) Platelets from aged rats aggregate more, but are more sensitive to prostacyclin. Prostaglandins Leukot Med 20:237-246
    • (1985) Prostaglandins Leukot Med , vol.20 , pp. 237-246
    • Giani, E.1    Masi, I.2    Galli, C.3
  • 21
    • 0027408273 scopus 로고
    • Beta-adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: A role for the endothelium and nitric oxide
    • Graves J, Poston L (1993) Beta-adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide. Br J Pharmacol 108:631-637
    • (1993) Br J Pharmacol , vol.108 , pp. 631-637
    • Graves, J.1    Poston, L.2
  • 22
    • 0026806047 scopus 로고
    • Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta
    • Gray DW, Marshall I (1992) Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol 107:684-690
    • (1992) Br J Pharmacol , vol.107 , pp. 684-690
    • Gray, D.W.1    Marshall, I.2
  • 23
    • 0028986867 scopus 로고
    • Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta
    • Gurdal H, Friedman E, Johnson MD (1995) Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta. Mol Pharmacol 47:772-778
    • (1995) Mol Pharmacol , vol.47 , pp. 772-778
    • Gurdal, H.1    Friedman, E.2    Johnson, M.D.3
  • 25
    • 27644555091 scopus 로고    scopus 로고
    • Cyclooxygenase-2: How good is it as a target for cancer chemoprevention?
    • Hull MA (2005) Cyclooxygenase-2: how good is it as a target for cancer chemoprevention? Eur J Cancer 41:1854-1863
    • (2005) Eur J Cancer , vol.41 , pp. 1854-1863
    • Hull, M.A.1
  • 26
    • 0023157679 scopus 로고
    • Age-related alterations in alpha 1- and beta-adrenoceptors mediated responsiveness of rat aorta
    • Hyland L, Warnock P, Docherty JR (1987) Age-related alterations in alpha 1- and beta-adrenoceptors mediated responsiveness of rat aorta. Naunyn-Schmiedebergs Arch Pharmacol 335:50-53
    • (1987) Naunyn-Schmiedebergs Arch Pharmacol , vol.335 , pp. 50-53
    • Hyland, L.1    Warnock, P.2    Docherty, J.R.3
  • 29
    • 0024344494 scopus 로고
    • Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats
    • Kamata K, Miyata N, Kasuya Y (1989) Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 249:890-894
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 890-894
    • Kamata, K.1    Miyata, N.2    Kasuya, Y.3
  • 30
    • 0021048924 scopus 로고
    • Role of endothelium in dilator responses of spontaneously hypertensive rat arteries
    • Konishi M, Su C (1983) Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 5:881-886
    • (1983) Hypertension , vol.5 , pp. 881-886
    • Konishi, M.1    Su, C.2
  • 31
    • 84939690460 scopus 로고
    • Beta-adrenoceptors in endothelium of rabbit coronary artery and alteration in atherosclerosis
    • Lu Z, Qu P, Xu K, Han C (1995) Beta-adrenoceptors in endothelium of rabbit coronary artery and alteration in atherosclerosis. Biol Signals 4:150-159
    • (1995) Biol Signals , vol.4 , pp. 150-159
    • Lu, Z.1    Qu, P.2    Xu, K.3    Han, C.4
  • 32
    • 0033180284 scopus 로고    scopus 로고
    • Age related changes in vascular responses
    • Marin J, Rodriguez-Martinez MA (1999) Age related changes in vascular responses. Exp Gerontol 34:503-512
    • (1999) Exp Gerontol , vol.34 , pp. 503-512
    • Marin, J.1    Rodriguez-Martinez, M.A.2
  • 33
    • 0033778214 scopus 로고    scopus 로고
    • Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids
    • Matz RL, de Sotomayor MA, Schott C, Stoclet JC, Andriantsitohaina R (2000a) Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br J Pharmacol 131:303-311
    • (2000) Br J Pharmacol , vol.131 , pp. 303-311
    • Matz, R.L.1    de Sotomayor, M.A.2    Schott, C.3    Stoclet, J.C.4    Andriantsitohaina, R.5
  • 34
    • 0033982738 scopus 로고    scopus 로고
    • Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products
    • Matz RL, Schott C, Stoclet JC, Andriantsitohaina R (2000b) Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products. Physiol Res 49:11-18
    • (2000) Physiol Res , vol.49 , pp. 11-18
    • Matz, R.L.1    Schott, C.2    Stoclet, J.C.3    Andriantsitohaina, R.4
  • 35
    • 0035979769 scopus 로고    scopus 로고
    • Maturation reveals a decrease in endothelium-dependent contraction induced by depolarization in the aorta of spontaneously hypertensive rats
    • Matz RL, Van Overloop B, Gaubert E, Gairard A (2001) Maturation reveals a decrease in endothelium-dependent contraction induced by depolarization in the aorta of spontaneously hypertensive rats. Life Sci 69:1791-1804
    • (2001) Life Sci , vol.69 , pp. 1791-1804
    • Matz, R.L.1    Van Overloop, B.2    Gaubert, E.3    Gairard, A.4
  • 37
    • 0026068870 scopus 로고
    • Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
    • Moncada S, Rees DD, Schulz R, Palmer RM (1991) Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA 88:2166-2170
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2166-2170
    • Moncada, S.1    Rees, D.D.2    Schulz, R.3    Palmer, R.M.4
  • 38
    • 0033040983 scopus 로고    scopus 로고
    • Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats
    • Numaguchi Y, Harada M, Osanai H, Hayashi K, Toki Y, Okumura K, Ito T, Hayakawa T (1999) Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Cardiovasc Res 41:682-688
    • (1999) Cardiovasc Res , vol.41 , pp. 682-688
    • Numaguchi, Y.1    Harada, M.2    Osanai, H.3    Hayashi, K.4    Toki, Y.5    Okumura, K.6    Ito, T.7    Hayakawa, T.8
  • 39
    • 0022446810 scopus 로고
    • Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by beta-adrenoceptor subtypes can be differentially regulated
    • O'Donnell SR, Wanstall JC (1986) Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by beta-adrenoceptor subtypes can be differentially regulated. Br J Pharmacol 88:41-49
    • (1986) Br J Pharmacol , vol.88 , pp. 41-49
    • O'Donnell, S.R.1    Wanstall, J.C.2
  • 40
    • 0025013973 scopus 로고
    • Changes in vascular wall production of prostacyclin and thromboxane A2 in spontaneously hypertensive rats during maturation and the concomitant development of hypertension
    • Osanai T, Matsumura H, Kikuchi T, Minami O, Yokono Y, Akiba R, Eidou H, Konta A, Kanazawa T, Onodera K et al (1990) Changes in vascular wall production of prostacyclin and thromboxane A2 in spontaneously hypertensive rats during maturation and the concomitant development of hypertension. Jpn Circ J 54:507-514
    • (1990) Jpn Circ J , vol.54 , pp. 507-514
    • Osanai, T.1    Matsumura, H.2    Kikuchi, T.3    Minami, O.4    Yokono, Y.5    Akiba, R.6    Eidou, H.7    Konta, A.8    Kanazawa, T.9    Onodera, K.10
  • 41
    • 0022873341 scopus 로고
    • Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man
    • Pan HY, Hoffman BB, Pershe RA, Blaschke TF (1986) Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther 239:802-807
    • (1986) J Pharmacol Exp Ther , vol.239 , pp. 802-807
    • Pan, H.Y.1    Hoffman, B.B.2    Pershe, R.A.3    Blaschke, T.F.4
  • 42
    • 0019497347 scopus 로고
    • Age-related increase in prostacyclin production in the rat aorta
    • Panganamala RV, Hanumaiah B, Merola AJ (1981) Age-related increase in prostacyclin production in the rat aorta. Prostaglandins Med 6:233-235
    • (1981) Prostaglandins Med , vol.6 , pp. 233-235
    • Panganamala, R.V.1    Hanumaiah, B.2    Merola, A.J.3
  • 43
    • 26244457463 scopus 로고    scopus 로고
    • Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery
    • Pourageaud F, Leblais V, Bellance N, Marthan R, Muller B (2005) Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery. Naunyn-Schmiedebergs Arch Pharmacol 372:14-23
    • (2005) Naunyn-Schmiedebergs Arch Pharmacol , vol.372 , pp. 14-23
    • Pourageaud, F.1    Leblais, V.2    Bellance, N.3    Marthan, R.4    Muller, B.5
  • 44
    • 0021987792 scopus 로고
    • Endothelium-removal decreases relaxations of canine coronary arteries caused by beta-adrenergic agonists and adenosine
    • Rubanyi G, Vanhoutte PM (1985) Endothelium-removal decreases relaxations of canine coronary arteries caused by beta-adrenergic agonists and adenosine. J Cardiovasc Pharmacol 7:139-144
    • (1985) J Cardiovasc Pharmacol , vol.7 , pp. 139-144
    • Rubanyi, G.1    Vanhoutte, P.M.2
  • 45
    • 0023239258 scopus 로고
    • Reduction with age in the relaxation to beta-adrenoceptor agonists and other vasodilators in rat aorta
    • Sawyer R, Docherty JR (1987) Reduction with age in the relaxation to beta-adrenoceptor agonists and other vasodilators in rat aorta. Naunyn-Schmiedebergs Arch Pharmacol 336:60-63
    • (1987) Naunyn-Schmiedebergs Arch Pharmacol , vol.336 , pp. 60-63
    • Sawyer, R.1    Docherty, J.R.2
  • 46
    • 0022993654 scopus 로고
    • Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle
    • Shimizu I, Toda N (1986) Alterations with age of the response to vasodilator agents in isolated mesenteric arteries of the beagle. Br J Pharmacol 89:769-778
    • (1986) Br J Pharmacol , vol.89 , pp. 769-778
    • Shimizu, I.1    Toda, N.2
  • 47
    • 0034048530 scopus 로고    scopus 로고
    • Aging increases PGHS-2-dependent vasoconstriction in rat mesenteric arteries
    • Stewart KG, Zhang Y, Davidge ST (2000) Aging increases PGHS-2-dependent vasoconstriction in rat mesenteric arteries. Hypertension 35:1242-1247
    • (2000) Hypertension , vol.35 , pp. 1242-1247
    • Stewart, K.G.1    Zhang, Y.2    Davidge, S.T.3
  • 48
    • 0034943516 scopus 로고    scopus 로고
    • Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes
    • Tilley SL, Coffman TM, Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108:15-23
    • (2001) J Clin Invest , vol.108 , pp. 15-23
    • Tilley, S.L.1    Coffman, T.M.2    Koller, B.H.3
  • 49
    • 0028296005 scopus 로고
    • Combined effects of age and exercise on thromboxane B2 and platelet activation
    • Todd MK, Goldfarb AH, Kauffman RD, Burleson C (1994) Combined effects of age and exercise on thromboxane B2 and platelet activation. J Appl Physiol 76:1548-1552
    • (1994) J Appl Physiol , vol.76 , pp. 1548-1552
    • Todd, M.K.1    Goldfarb, A.H.2    Kauffman, R.D.3    Burleson, C.4
  • 50
    • 0023036993 scopus 로고
    • Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation
    • Tsujimoto G, Lee CH, Hoffman BB (1986) Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation. J Pharmacol Exp Ther 239:411-415
    • (1986) J Pharmacol Exp Ther , vol.239 , pp. 411-415
    • Tsujimoto, G.1    Lee, C.H.2    Hoffman, B.B.3
  • 52
    • 0034717101 scopus 로고    scopus 로고
    • Age-related involvement of the endothelium in beta-adrenoceptor- mediated relaxation of rat aorta
    • van der Zypp A, Kang KB, Majewski H (2000) Age-related involvement of the endothelium in beta-adrenoceptor- mediated relaxation of rat aorta. Eur J Pharmacol 397:129-138
    • (2000) Eur J Pharmacol , vol.397 , pp. 129-138
    • van der Zypp, A.1    Kang, K.B.2    Majewski, H.3
  • 53
    • 0035206974 scopus 로고    scopus 로고
    • MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms
    • Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, Tanaka Y (2001) MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn Schmiedebergs Arch Pharmacol 364:538-550
    • (2001) Naunyn Schmiedebergs Arch Pharmacol , vol.364 , pp. 538-550
    • Yamaki, F.1    Kaga, M.2    Horinouchi, T.3    Tanaka, H.4    Koike, K.5    Shigenobu, K.6    Toro, L.7    Tanaka, Y.8


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