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Volumn 128, Issue 2, 2008, Pages 190-193

Molecular targeted therapy in colorectal cancer;Molekylært rettet behandling av kolorektal cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CYTOSTATIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR;

EID: 38749086877     PISSN: 00292001     EISSN: 08077096     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (29)
  • 1
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AV, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2: 563-72.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.V.2    MacDonald, I.C.3
  • 2
    • 28444476260 scopus 로고    scopus 로고
    • Angiogenic inhibitors: A new therapeutic strategy in oncology
    • Gasparini G, Longo R, Toi M et al. Angiogenic inhibitors: a new therapeutic strategy in oncology. Nat Clin Pract Oncol 2005; 2: 562-77.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 562-577
    • Gasparini, G.1    Longo, R.2    Toi, M.3
  • 3
    • 33846541373 scopus 로고    scopus 로고
    • Novel targets for anticancer treatment development in colorectal cancer
    • Macarulla T, Ramos FJ, Capdevila J et al. Novel targets for anticancer treatment development in colorectal cancer. Clin Colorectal Cancer 2006; 6: 265-72.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 265-272
    • Macarulla, T.1    Ramos, F.J.2    Capdevila, J.3
  • 4
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 5
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-5.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 6
    • 41749125958 scopus 로고    scopus 로고
    • Saltz LB, Clarke S, Diaz-Rubio E et al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: efficacy results from XELOX-1/NO16966, a randomized phase III trial in the first-line treatment of metastatic colorectal cancer (MCRC). 2007 Gastrointestinal Cancers Symposium; abstract 238. www.asco.org/portal/site/ ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID= 45&abstractID=10580 (16.11.2007).
    • Saltz LB, Clarke S, Diaz-Rubio E et al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: efficacy results from XELOX-1/NO16966, a randomized phase III trial in the first-line treatment of metastatic colorectal cancer (MCRC). 2007 Gastrointestinal Cancers Symposium; abstract 238. www.asco.org/portal/site/ ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID= 45&abstractID=10580 (16.11.2007).
  • 7
    • 41749090058 scopus 로고    scopus 로고
    • Sugrue MM, Kozloff M, Hainsworth J et al. Safety and effectiveness of bevacizumab plus chemotherapy in elderly patients with mCRC: results from the BRiTE registry. 2007 Gastrointestinal Cancers Symposium; abstract 345. www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/? vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview= abst_detail_view&confID=45&abstractID=10653 (16.11.2007).
    • Sugrue MM, Kozloff M, Hainsworth J et al. Safety and effectiveness of bevacizumab plus chemotherapy in elderly patients with mCRC: results from the BRiTE registry. 2007 Gastrointestinal Cancers Symposium; abstract 345. www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/? vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview= abst_detail_view&confID=45&abstractID=10653 (16.11.2007).
  • 8
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group study E2200
    • Giantonio BJ, Levy DE, O'dwyer PJ et al. A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the Eastern Cooperative Oncology Group study E2200. Ann Oncol 2006; 17: 1399-403.
    • (2006) Ann Oncol , vol.17 , pp. 1399-1403
    • Giantonio, B.J.1    Levy, D.E.2    O'dwyer, P.J.3
  • 9
    • 34247131745 scopus 로고    scopus 로고
    • Adjuvant therapy for stage II and III colorectal cancer
    • de Gramont A, Tournigand C, André T et al. Adjuvant therapy for stage II and III colorectal cancer. Semin Oncol 2007; 34: S37-40.
    • (2007) Semin Oncol , vol.34
    • de Gramont, A.1    Tournigand, C.2    André, T.3
  • 10
    • 34247848005 scopus 로고    scopus 로고
    • Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results
    • Czito BG, Bendell JC, Willett CG et al. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: phase I trial results. Int J Radiat Oncol Biol Phys 2007; 68: 472-8.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 472-478
    • Czito, B.G.1    Bendell, J.C.2    Willett, C.G.3
  • 11
    • 21344432989 scopus 로고    scopus 로고
    • Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of bevacizumab and cetuximab: An Acta Oncologica expert report
    • Nygren P, Sørbye H, Österlund P et al. Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of bevacizumab and cetuximab: an Acta Oncologica expert report. Acta Oncol 2005; 44: 203-17.
    • (2005) Acta Oncol , vol.44 , pp. 203-217
    • Nygren, P.1    Sørbye, H.2    Österlund, P.3
  • 12
    • 18844429786 scopus 로고    scopus 로고
    • Molecularly targeted therapy for gastrointestinal cancer
    • Wiedmann MW, Caca K. Molecularly targeted therapy for gastrointestinal cancer. Curr Cancer Drug Targets 2005; 5: 171-93.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 171-193
    • Wiedmann, M.W.1    Caca, K.2
  • 13
    • 9744248657 scopus 로고    scopus 로고
    • Targeted therapy in advanced colon cancer: The role of new therapies
    • iv55-62
    • Tabernero J, Salazar R, Casado E et al. Targeted therapy in advanced colon cancer: the role of new therapies. Ann Oncol 2004; 15 (suppl 4): iv55-62.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 4
    • Tabernero, J.1    Salazar, R.2    Casado, E.3
  • 14
    • 34548610593 scopus 로고    scopus 로고
    • Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): The CRYSTAL trial
    • abstract 4000. Philadelphia, PA: American Society of Clinical Oncology
    • Van Cutsem E, Nowacki M, Lang I et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial. 2007 Annual Meeting of the American Society of Clinical Oncology; abstract 4000. Philadelphia, PA: American Society of Clinical Oncology, 2007.
    • (2007) Annual Meeting of the American Society of Clinical Oncology , pp. 2007
    • Van Cutsem, E.1    Nowacki, M.2    Lang, I.3
  • 15
    • 34547147534 scopus 로고    scopus 로고
    • Randomized phase III trial of cetuximab plus irinotecan versus irinotecan alone for metastatic colorectal cancer in 1298 patients who have failed prior oxaliplatin-based therapy: The EPIC trial
    • abstract 3536. Philadelphia, PA: American Society of Clinical Oncology
    • Sobrero AF, Fehrenbacher L, Rivera F et al. Randomized phase III trial of cetuximab plus irinotecan versus irinotecan alone for metastatic colorectal cancer in 1298 patients who have failed prior oxaliplatin-based therapy: the EPIC trial. 2007 Annual Meeting of the American Association for Cancer Research; abstract 3536. Philadelphia, PA: American Society of Clinical Oncology, 2007.
    • (2007) Annual Meeting of the American Association for Cancer Research , pp. 2007
    • Sobrero, A.F.1    Fehrenbacher, L.2    Rivera, F.3
  • 16
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. New Engl J Med 2004; 351: 337-45.
    • (2004) New Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 17
    • 33847261015 scopus 로고    scopus 로고
    • Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy
    • Souglakos J, Kalykaki A, Vamvakas L et al. Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy. Ann Oncol 2007; 18: 305-10.
    • (2007) Ann Oncol , vol.18 , pp. 305-310
    • Souglakos, J.1    Kalykaki, A.2    Vamvakas, L.3
  • 18
    • 2142641698 scopus 로고    scopus 로고
    • Saltz LB, Meropol NJ, Loehrer PJ sr. et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-8.
    • Saltz LB, Meropol NJ, Loehrer PJ sr. et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-8.
  • 19
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz HJ, Van Cutsem E, Khambata-Ford S et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006; 24: 4914-21.
    • (2006) J Clin Oncol , vol.24 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3
  • 20
    • 33751169352 scopus 로고    scopus 로고
    • Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer
    • Hofheinz RD, Horisberger K, Woernle C et al. Phase I trial of cetuximab in combination with capecitabine, weekly irinotecan, and radiotherapy as neoadjuvant therapy for rectal cancer. Int J Radiat Oncol Biol Phys 2006; 66: 1384-90.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1384-1390
    • Hofheinz, R.D.1    Horisberger, K.2    Woernle, C.3
  • 21
    • 34047179551 scopus 로고    scopus 로고
    • Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer
    • Machiels JP, Sempoux C, Scalliet P et al. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann Oncol 2007; 18: 738-44.
    • (2007) Ann Oncol , vol.18 , pp. 738-744
    • Machiels, J.P.1    Sempoux, C.2    Scalliet, P.3
  • 22
    • 33745909120 scopus 로고    scopus 로고
    • Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer
    • Gibson TB, Ranganathan A, Grothey A. Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer. Clin Colorectal Cancer 2006; 6: 29-31.
    • (2006) Clin Colorectal Cancer , vol.6 , pp. 29-31
    • Gibson, T.B.1    Ranganathan, A.2    Grothey, A.3
  • 23
    • 41749101288 scopus 로고    scopus 로고
    • Saltz LB, Lenz HJ, Kindler H et al. Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. 2005 Gastrointestinal Cancers Symposium; abstract 169b. www.asco.org/portal/site/ASCO/menuitem. 34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID= 36&index=y&abstractID=10273 (16.11.2007).
    • Saltz LB, Lenz HJ, Kindler H et al. Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. 2005 Gastrointestinal Cancers Symposium; abstract 169b. www.asco.org/portal/site/ASCO/menuitem. 34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=abst_detail_view&confID= 36&index=y&abstractID=10273 (16.11.2007).
  • 24
    • 41749120353 scopus 로고    scopus 로고
    • Amgen discontinues Vectibix™ treatment in PACCE trial evaluating Vectibix™ as part of triple combination regimen. Pressemelding (Amgen) 22.3.2007. www.reuters.com/article/inPlayBriefing/ idUSIN20070322173707AMGN20070322 (16.11.2007).
    • Amgen discontinues Vectibix™ treatment in PACCE trial evaluating Vectibix™ as part of triple combination regimen. Pressemelding (Amgen) 22.3.2007. www.reuters.com/article/inPlayBriefing/ idUSIN20070322173707AMGN20070322 (16.11.2007).
  • 25
    • 33750596636 scopus 로고    scopus 로고
    • Mechanisms of disease: Cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy
    • Drosten M, Putzer BM. Mechanisms of disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy. Nat Clin Pract Oncol 2006; 3: 564-74.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 564-574
    • Drosten, M.1    Putzer, B.M.2
  • 26
    • 23944469938 scopus 로고    scopus 로고
    • Targeting signal transduction pathways in colorectal cancer - more than skin deep
    • Cohen SJ, Cohen RB, Meropol NJ. Targeting signal transduction pathways in colorectal cancer - more than skin deep. J Clin Oncol 2005; 23, 5374-85.
    • (2005) J Clin Oncol , vol.23 , pp. 5374-5385
    • Cohen, S.J.1    Cohen, R.B.2    Meropol, N.J.3
  • 27
    • 5444241523 scopus 로고    scopus 로고
    • Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer
    • Rao S, Cunningham D, de Gramont A et al. Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer. J Clin Oncol 2004; 22: 3950-7.
    • (2004) J Clin Oncol , vol.22 , pp. 3950-3957
    • Rao, S.1    Cunningham, D.2    de Gramont, A.3
  • 28
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF-signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F et al. Oncogenic activation of the RAS/RAF-signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007; 67: 2643-8.
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 29
    • 0036898832 scopus 로고    scopus 로고
    • Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter
    • Sträter J, Hinz U, Walczak H et al. Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. Clin Cancer Res 2002; 8: 3734-40.
    • (2002) Clin Cancer Res , vol.8 , pp. 3734-3740
    • Sträter, J.1    Hinz, U.2    Walczak, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.