Treating common ear problems in pregnancy: What is safe?

European Archives of Oto-Rhino-Laryngology

Volumn 265, Issue 2, 2008, Pages 139-145

  Vlastarakos, Petros V ^a,c   Nikolopoulos, Thomas P ^a   Manolopoulos, Leonidas ^a   Ferekidis, Eleftherios ^a   Kreatsas, George ^b  

^a HIPPOKRATION HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c NONE   (Greece)

Author keywords

Drugs; Ear; Pregnancy; Safety; Teratogenicity

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; ANTIHISTAMINIC AGENT; BETA LACTAM ANTIBIOTIC; BETAHISTINE; BUDESONIDE; CETIRIZINE; CLARITHROMYCIN; CLOTRIMAZOLE; CORTICOSTEROID; DECONGESTIVE AGENT; DIAZEPAM; DIMENHYDRINATE; DIURETIC AGENT; ERYTHROMYCIN; GINGER EXTRACT; HISTAMINE H2 RECEPTOR ANTAGONIST; IBUPROFEN; LORATADINE; MACROLIDE; MECLOZINE; METOCLOPRAMIDE; NIZATIDINE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; PREDNISONE; PROTON PUMP INHIBITOR; PYRIDOXINE; UNINDEXED DRUG; VASODILATOR AGENT;

BELL PALSY; CLEFT PALATE; DISEASE SEVERITY; DRUG CONTRAINDICATION; DRUG MECHANISM; DRUG SAFETY; DRUG WITHDRAWAL; EAR DISEASE; EAR INFECTION; FACIAL NERVE PARALYSIS; FOOD AND DRUG ADMINISTRATION; GASTROSCHISIS; HERPES ZOSTER OTICUS; HUMAN; HYPERBILIRUBINEMIA; HYPONATREMIA; KIDNEY DISEASE; LOW DRUG DOSE; MENIERE DISEASE; MOTION SICKNESS; NONHUMAN; OTOMYCOSIS; PLACENTA PERFUSION; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SUDDEN DEAFNESS; SURGICAL TECHNIQUE; TERATOGENICITY; THROMBOCYTOPENIA; VERTIGO; VOMITING; XEROPHTHALMIA;

ANTI-BACTERIAL AGENTS; FEMALE; FETAL DISEASES; HUMANS; OTITIS MEDIA; PREGNANCY; PREGNANCY COMPLICATIONS; TERATOGENS;

EID: 38749084919     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-007-0534-3     Document Type: Review

References (105)

1. Holt GR, Mabry RL (1983) ENT medications in pregnancy. Otolaryngol Head Neck Surg 91:338-41
2. Abrams RS (1990) Will it hurt the baby? The safe use of medications during pregnancy and breastfeeding. Addison-Wesley, Reading, pp 1-5
3. Rubin PC (1986) Prescribing in pregnancy. General principles. BMJ 293:1415-1417
4. Moore KL (1988) The developing human: clinically oriented embryology, 4th edn. W.B. Saunders, Philadelphia, p 131
5. Schatz M (1997) Asthma treatment during pregnancy. What can be safely taken? Drug Saf 16(5):342-350
6. Ekelund H, Kullander S, Kallen B (1970) Major and minor malformations in newborns and infants up to one year of age. Acta Paediatr Scand 59:297-302
7. Ash P, Vennart J, Carter CO (1977) The incidence of hereditary disease in man. J Med Genet 14:305
8. Sa del Fiol F, Gerenutti M, Groppo FC (2005) Antibiotics and pregnancy. Pharmazie 60(7):483-493
9. Goodnight WH, Soper DE (2005) Pneumonia in pregnancy. Crit Care Med 33(10 Suppl):S390-S397
10. Lim WS, Macfarlane JT, Colthorpe CL (2003) Treatment of community-acquired lower respiratory tract infections during pregnancy. Am J Respir Med 2(3):221-233
11. Miller EL (2002) The penicillins: a review and update. J Midwifery Womens Health 47(6):426-434
12. Christensen B (2000) Which antibiotics are appropriate for treating bacteriuria in pregnancy? J Antimicrob Chemother 46(Suppl 1):29-34 discussion 63-65
13. Rouveix B, Levacher M, Giroud JP (1999) Drugs for respiratory tropism and pregnancy (article in French). Rev Pneumol Clin 55(5):338-343
14. Garland SM, O'Reilly MA (1995) The risks and benefits of antimicrobial therapy in pregnancy Drug Saf 13(3):188-205
15. Friese K (1993) Antibiotic therapy in pregnancy (article in German). Immun Infekt 21(4):111-114
16. Leophonte P (1988) Antibiotics during pregnancy and breast feeding: consequences for the treatment of respiratory infections. Rev Mal Respir 5(3):293-298
17. Ellegard EK (2004) Clinical and pathogenetic characteristics of pregnancy rhinitis. Clin Rev Allergy Immunol 26(3):149-159
18. Heikkila A, Erkkola R (1994) Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedules. Clin Pharmacokinet 27(1):49-62
19. Mucklow JC (1986) The fate of drugs in pregnancy. Clin Obstet Gynaecol 13(2):161-175
20. Brocklehurst P (2002) Antibiotics for gonorrhoea in pregnancy. Cochrane Database Syst Rev (2):CD000098
21. Di Lorenzo G, Mansueto P, Melluso M, Purello D'Ambrosio F, Putignano E, Barbagallo Sangiorgi G (1994) Allergy in pregnancy (article in Italian). Clin Ter 145(9):223-229
22. Sarkar M, Woodland C, Koren G, Einarson AR (2006) Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 6(5):18
23. Källén BA, Otterblad Olausson P, Danielsson BR (2005) Is erythromycin therapy teratogenic in humans? Reprod Toxicol 20(2):209-214
24. Källén BA, Otterblad Olausson P (2003) Maternal drug use in early pregnancy and infant cardiovascular defect. Reprod Toxicol 17(3):255-261
25. Czeizel A, Rockenbauer M, Sørensen HT, Olsen J (1999) A population-based case-control teratologic study of oral erythromycin treatment during pregnancy. Reprod Toxicol 13(6):531-536
26. Louik C, Werler MM, Mitchell AA (2002) Erythromycin use during pregnancy in relation to pyloric stenosis. Am J Obstet Gynecol 186(2):288-290
27. Amsden GW (1996) Erythromycin, clarithromycin, and azithromycin: are the differences real? Clin Ther 18(1):56-72 discussion 55
28. Chun JY, Han JY, Ahn HK, Choi JS, Koong MK, Nava-Ocampo AA, Koren G (2006) Fetal outcome following roxithromycin exposure in early pregnancy. J Matern Fetal Neonatal Med 19(3):189-92
29. Bogacka E (1999) Decongestants in treatment of nasal obstruction (article in Polish/abstract). Otolaryngol Pol 53(3):347-352
30. Mazzotta P, Loebstein R, Koren G (1999) Treating allergic rhinitis in pregnancy. Safety considerations. Drug Saf 20(4):361-375
31. Naclerio RM (1998) Optimizing treatment options. Clin Exp Allergy 28(Suppl 6):54-59
32. Gilbert C, Mazzotta P, Loebstein R, Koren G (2005) Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review. Drug Saf 28(8):707-719
33. Keles N (2004) Treatment of allergic rhinitis during pregnancy. Am J Rhinol 18(1):23-28
34. Schatz M, Zeiger RS, Harden K, Hoffman CC, Chilingar L, Petitti D (1997) The safety of asthma and allergy medications during pregnancy. J Allergy Clin Immunol 100(3):301-306
35. Demoly P, Piette V, Daures JP (2003) Treatment of allergic rhinitis during pregnancy (article in French). Drugs 63(17):1813-1820
36. Gilbert-Barness E, Drut RM (2000) Association of sympathomimetic drugs with malformations. Vet Hum Toxicol 42(3):168-171
37. Ugen KE, Scott WJ Jr (1987) Reduction of uterine blood flow by phenylephrine, an alpha-adrenergic agonist, in the day 11 pregnant rat: relationship to potentiation of acetazolamide teratogenesis. Teratology 36(1):133-141
38. No authors listed (2000) The use of newer asthma and allergy medications during pregnancy. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI). Ann Allergy Asthma Immunol 84(5):475-480
39. No authors listed (2004) Gastroschisis and pseudoephedrine during pregnancy. Prescrire Int 13(72):141-143
40. Werler MM (2006) Teratogen update: pseudoephedrine. Birth Defects Res A Clin Mol Teratol 76(6):445-452
41. Torfs CP, Katz EA, Bateson TF, Lam PK, Curry CJ (1996) Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology 54(2):84-92
42. Werler MM, Mitchell AA, Shapiro S (1992) First trimester maternal medication use in relation to gastroschisis. Teratology 45(4):361-367
43. Blaiss MS (2003) Food, drug administration (US); ACAAI-ACOG (American College of Allergy, Asthma, and Immunology and American College of Obstetricians and Gynecologists). Management of rhinitis and asthma in pregnancy. Ann Allergy Asthma Immunol 90(6 Suppl 3):16-22
44. Gluck PA, Gluck JC (2005) A review of pregnancy outcomes after exposure to orally inhaled or intranasal budesonide. Curr Med Res Opin 21(7):1075-1084
45. Osur SL (2005) The management of asthma and rhinitis during pregnancy. J Womens Health (Larchmt) 14(3):263-276
46. Gani F, Braida A, Lombardi C, Del Giudice A, Senna GE, Passalacqua G (2003) Rhinitis in pregnancy. Allerg Immunol (Paris) 35(8):306-313
47. Paris-Kohler A, Megret-Gabeaud ML, Fabre C, Mares P, Vincent D (2001) The allergic pregnant woman (article in French). Allerg Immunol (Paris) 33(10):399-403
48. Bothamley G (2001) Drug treatment for tuberculosis during pregnancy: safety considerations. Drug Saf 24(7):553-565
49. Shehata H, Nelson-Piercy C (2001) Drugs to avoid. Best Pract Res Clin Obstet Gynaecol 15(6):971-986
50. Ostensen ME, Skomsvoll JF (2004) Anti-inflammatory pharmacotherapy during pregnancy. Expert Opin Pharmacother 5(3):571-80
51. Fardet L, Nizard J, Genereau T (2002) Non-selective and selective non-steroidal anti-inflammatory drugs, administration in pregnancy and breast feeding (article in French). Presse Med 31(31):1462-1468
52. Burdan F, Belzek A (2001) Current opinions on embryotoxic and teratogenic effects of ibuprofen (article in Polish/abstract). Pol Merkuriusz Lek 11(63):266-270
53. Ostensen M (1998) Nonsteroidal anti-inflammatory drugs during pregnancy. Scand J Rheumatol Suppl 107:128-132
54. Ostensen M, Ramsey-Goldman R (1998) Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options? Drug Saf 19(5):389-410
55. Ostensen M (1994) Optimisation of antirheumatic drug treatment in pregnancy. Clin Pharmacokinet 27(6):486-503
56. Schoenfeld A, Bar Y, Merlob P, Ovadia Y (1992) NSAIDs: maternal and fetal considerations. Am J Reprod Immunol 28(3-4):141-147
57. Burdan F (2001) Prenatal effects of acetylsalicylic acid (article in Polish/abstract). Pol Merkuriusz Lek 11(62):182-186
58. De Santis M, Carducci B, Cavaliere AF, De Santis L, Straface G, Caruso A (2001) Drug-induced congenital defects: strategies to reduce the incidence. Drug Saf 24(12):889-901
59. Janssen NM, Genta MS (2000) The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med 160(5):610-619
60. Gran JT, Ostensen M (1998) Spondyloarthritides in females. Baillieres Clin Rheumatol 12(4):695-715
61. Pfaffenrath V, Rehm M (1998) Migraine in pregnancy: what are the safest treatment options? Drug Saf 19(5):383-388
62. Werler MM, Sheehan JE, Mitchell AA (2002) Maternal medication use and risks of gastroschisis and small intestinal atresia. Am J Epidemiol 155(1):26-31
63. Ericson A, Källén BA (2001) Nonsteroidal anti-inflammatory drugs in early pregnancy. Reprod Toxicol 15(4):371-375
64. Yodfat Y (2004) Is there a future for COX-2 inhibitors? (article in Hebrew/abstract) Harefuah 143(11):820-824 837
65. Chan VS (2004) A mechanistic perspective on the specificity and extent of COX-2 inhibition in pregnancy. Drug Saf 27(7):421-426
66. Bannwarth B, Pehourcq F (2003) Pharmacologic basis for using paracetamol: pharmacokinetic and pharmacodynamic issues. Drugs 63(2):5-13
67. Berkovitch M, Diav-Citrin O, Greenberg R, Cohen M, Bulkowstein M, Shechtman S, Bortnik O, Arnon J, Ornoy A (2004) First-trimester exposure to amoxycillin/clavulanic acid: a prospective, controlled study. Br J Clin Pharmacol 58(3):298-302
68. Czeizel AE, Rockenbauer M, Sorensen HT, Olsen J (2001) Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study. Eur J Obstet Gynecol Reprod Biol 97(2):188-192
69. Fairbanks DNF (2003) Pocket guide to antimicrobial therapy in otolaryngology-head and neck surgery, 11th edn. American Academy of Otolaryngology-Head and Neck Surgery Foundation
70. Loh KY, Sivalingam N (2005) Understanding hyperemesis gravidarum. Med J Malaysia 60(3):394-399. Quiz 400
71. Nelson-Piercy C (1998) Treatment of nausea and vomiting in pregnancy. When should it be treated and what can be safely taken? Drug Saf 19(2):155-164
72. Magee LA, Mazzotta P, Koren G (2002) Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP). Am J Obstet Gynecol 186(5 Suppl Understanding):S256-S261
73. Flake ZA, Scalley RD, Bailey AG (2004) Practical selection of antiemetics. Am Fam Physician 69(5):1169-1174
74. Leathem AM (1986) Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. Clin Pharm 5(8):660-668
75. Schroder O, Stein J (2002) Vomiting in pregnancy. When is it more than only a bothersome nuisance? (article in German). MMW Fortschr Med 144(50):32-34
76. Jewell D, Young G (2003) Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev (4):CD000145
77. Langner E, Greifenberg S, Gruenwald J (1998) Ginger: history and use. Adv Ther 15(1):25-44
78. Borrelli F, Capasso R, Aviello G, Pittler MH, Izzo AA (2005) Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol 105(4):849-856
79. Betz O, Kranke P, Geldner G, Wulf H, Eberhart LH (2005) Is ginger a clinically relevant antiemetic? A systematic review of randomized controlled trials (article in German). Forsch Komplementarmed Klass Naturheilkd 12(1):14-23
80. Bryer E (2005) A literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy. J Midwifery Womens Health 50(1):1-3
81. http://www.medicinenet.com
82. Uchide K, Suzuki N, Takiguchi T, Terada S, Inoue M (1997) The possible effect of pregnancy on Meniere's disease. ORL J Otorhinolaryngol Relat Spec 59(5):292-295
83. Kyle PM, Redman CW (1992) Comparative risk-benefit assessment of drugs used in the management of hypertension in pregnancy. Drug Saf 7(3):223-234
84. Hansen L, Sobol S, Abelson T (1986) Otolalyngologic manifestations of pregnancy. J Fam Pract 23(2):151-155
85. Huynh-Do U, Frey FJ (2000) Potential dangers of diuretics (article in German). Ther Umsch 57(6):408-411
86. Oren D, Nulman I, Makhija M, Ito S, Koren G (2004) Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk? Can Fam Physician 50:1083-1085
87. Schatz M (2001) The efficacy and safety of asthma medications during pregnancy. Semin Perinatol 25(3):145-152
88. Park-Wyllie L, Mazzotta P, Pastuszak A, Moretti ME, Beique L, Hunnisett L, Friesen MH, Jacobson S, Kasapinovic S, Chang D, Diav-Citrin O, Chitayat D, Nulman I, Einarson TR, Koren G (2000) Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 62(6):385-392
89. Ambro BT, Scheid SC, Pribitkin EA (2003) Prescribing guidelines for ENT medications during pregnancy. ENT J 82(8):565-568
90. Lockshin MD, Sammaritano LR (1998) Corticosteroids during pregnancy. Scand J Rheumatol Suppl 107:136-138
91. Guillonneau M, Jacqz-Aigrain E (1996) Maternal corticotherapy. Pharmacology and effect on the fetus (article in French). J Gynecol Obstet Biol Reprod (Paris) 25(2):160-167
92. Garbis H, Elefant E, Diav-Citrin O, Schaefer C, Vial T, Clementi M, Valti E, McElhatton P, Smorlesi C, Rodriguez EP, Robert-Gnansia E, Merlob P, Peiker G, Pexieder T, Schueler L, Ritvanen A, Mathieu-Nolf M (2005) Pregnancy outcome after exposure to ranitidine and other H2-blockers. A collaborative study of the European Network of Teratology Information Services. Reprod Toxicol 19(4):453-458
93. Cappell MS (2003) Gastric and duodenal ulcers during pregnancy. Gastroenterol Clin North Am 32(1):263-308
94. Charan M, Katz PO (2001) Gastroesophageal reflux disease in pregnancy. Curr Treat Options Gastroenterol 4(1):73-81
95. Michaletz-Onody PA (1992) Peptic ulcer disease in pregnancy. Gastroenterol Clin North Am 21(4):817-826
96. Kyle PM (2006) Drugs and the fetus. Curr Opin Obstet Gynecol 18(2):93-99
97. Diav-Citrin O, Arnon J, Shechtman S, Schaefer C, van Tonningen MR, Clementi M, De Santis M, Robert-Gnansia E, Valti E, Malm H, Ornoy A (2005) The safety of proton pump inhibitors in pregnancy: a multicentre prospective controlled study. Aliment Pharmacol Ther 21(3):269-275
98. Richter JE (2003) Gastroesophageal reflux disease during pregnancy. Gastroenterol Clin North Am 32(1):235-261
99. Nikfar S, Abdollahi M, Moretti ME, Magee LA, Koren G (2002) Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysis. Dig Dis Sci 47(7):1526-1529
100. Nielsen GL, Sorensen HT, Thulstrup AM, Tage-Jensen U, Olesen C, Ekbom A (1999) The safety of proton pump inhibitors in pregnancy. Aliment Pharmacol Ther 13(8):1085-1089
101. Nava-Ocampo AA, Velázquez-Armenta EY, Han JY, Koren G (2006) Use of proton pump inhibitors during pregnancy and breastfeeding. Can Fam Physician 52:853-854
102. Källén BA (2001) Use of omeprazole during pregnancy-no hazard demonstrated in 955 infants exposed during pregnancy. Eur J Obstet Gynecol Reprod Biol 96(1):63-68
103. Tyring SK, Baker D, Snowden W (2002) Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovir. J Infect Dis 186(Suppl 1):S40-S46
104. Haddad J, Messer J, Willard D, Ritter J (1989) Acyclovir and pregnancy: current aspects (article in French). J Gynecol Obstet Biol Reprod (Paris) 18(5):679-683
105. May M (1980) Bell's palsy: diagnosis, prognosis and treatment. Surg Rounds 13(1):38-48