Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: Correlation with outcome in solid organ transplant recipients with cryptococcosis

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 2, 2008, Pages 735-738

  Kontoyiannis, Dimitrios P ^a   Lewis, Russell E ^a   Alexander, Barbara D ^b   Lortholary, Olivier ^c   Dromer, Françoise ^d   Gupta, Krishan L ^e   John, George T ^f   Del Busto, Ramon ^g   Klintmalm, Goran B ^h   Somani, Jyoti ⁱ   Lyon, G Marshall ⁱ   Pursell, Kenneth ^j   Stosor, Valentina ^k   Muňoz, Patricia ^l   Limaye, Ajit P ^m   Kalil, Andre C ⁿ   Pruett, Timothy L ^o   Garcia Diaz, Julia ^p   Humar, Atul ^q   Houston, Sally ^r   House, Andrew A ^s   Wray, Dannah ^t   Orloff, Susan ^u   Dowdy, Lorraine A ^v   Fisher, Robert A ^w   Heitman, Joseph ^c   Albert, Nathaniel D ^a   Wagener, Marilyn M ^x   Singh, Nina ^x,y   more..

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d INSTITUT PASTEUR   (France)

^e POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^f CHRISTIAN MEDICAL COLLEGE   (India)

^g HENRY FORD HOSPITAL   (United States)

^h BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

ⁱ EMORY UNIVERSITY   (United States)

^j UNIVERSITY OF CHICAGO   (United States)

^k NORTHWESTERN UNIVERSITY   (United States)

^l HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^m UNIVERSITY OF WASHINGTON   (United States)

ⁿ UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^o UNIVERSITY OF VIRGINIA   (United States)

^p OCHSNER CLINIC FOUNDATION   (United States)

^q TORONTO GENERAL HOSPITAL   (Canada)

^r UNIVERSITY OF SOUTH FLORIDA   (United States)

^s UNIVERSITY OF WESTERN ONTARIO   (Canada)

^t MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^u OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^v UNIVERSITY OF MIAMI   (United States)

^w VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^x VA Healthcare VISN 4   (United States)

^y UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CALCINEURIN INHIBITOR; CYCLOSPORIN A; FLUCONAZOLE; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS;

ARTICLE; CORRELATION ANALYSIS; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; GRAFT SURVIVAL; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; NONHUMAN; ORGAN TRANSPLANTATION; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTOZOAL INFECTION; REACTION OPTIMIZATION; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

ANTIFUNGAL AGENTS; CALCINEURIN; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DRUG SYNERGISM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICROBIAL SENSITIVITY TESTS; ORGAN TRANSPLANTATION; TACROLIMUS; TREATMENT OUTCOME;

EID: 38649141183     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00990-07     Document Type: Article

References (23)

1. Alexander, B. D. 2005. Cryptococcosis after solid organ transplantation. Transplant Infect. Dis. 7:1-3.
2. Aller, A., R. Claro, C. Castro, C. Serrano, M. Colom, E. Martin-Mazuelos, and the Groupo de Epidemiologia de la Cryptococcosis. 2007. Antifungal susceptibility of Cryptococcus neoformans isolates in HIV-infected patients to fluconazole, itraconazole and voriconazole in Spain: 1994-1996 and 1997-2005. Chemotherapy 53:300-305.
3. Ascioglu, S., J. H. Rex, J. E. Bennett, J. Billie, F. Croksert, D. W. Denning, et al. 2002. Defining opportunistic invasive fungal infections in immunocom-promised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin. Infect. Dis. 34:7-14.
4. Barry, A., M. Pfaller, S. Brown, A. Espinel-Ingroff, M. Ghannoum, C. Knapp, R. Rennie, J. Rex, and M. Rinaldi. 2000. Quality control limits for broth microdilution susceptibility tests of ten antifungal agents. J. Clin. Microbiol. 38:3457-3459.
5. Cardenas, M. E., N. S. Cutler, M. C. Lorenz, C. J. DiComo, and J. Heitman. 1999. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:3271-3279.
6. Cruz, M. C., A. L. Goldstein, J. Blankenship, M. Del Poeta, J. Perfect, J. H. McCusker, Y. L. Bennani, M. E. Cardenas, and J. Heitman. 2001. Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrob. Agents Chemother. 45:3162-3170.
7. Cruz, M. C., A. L. Goldstein, J. R. Blankenship, M. Del Poeta, D. Davis, M. E. Cardenas, John R. Perfect, John H. McCusker, and Joseph Heitman. 2002. Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J. 21:546-559.
8. Cruz, M. C., R. A. L. Sia, M. Olson, C. M. Cox, and J. Heitman. 2000. Comparisons of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infect. Immun. 68:982-985.
9. Dannaoui, E., M. Abdul, M. Arpin, A. Michel-Nguyen, M. Piens, A. Favel, O. Lortholary, F. Dromer, and the French Cryptococcosis Study Group. 2006. Results obtained with various antifungal susceptibility testing methods do not predict early clinical outcome in patients with cryptococcosis. Antimicrob. Agents Chemother. 50:2464-2470.
10. 1, fluconazole, and the pneumocandin MD-0991 caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob. Agents Chemother. 44:739-746.
11. Gorlach, J., D. S. Fox, N. S. Cutler, G. M. Cox, J. R. Perfect, and J. Heitman. 2000. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. EMBO J. 19:3618-3629.
12. Husain, S., M. M. Wagener, and N. Singh. 2001. Cryptococcus neoformans in organ transplant recipients: correlates of variability in clinical characteristics and outcome. Emerg. Infect. Dis. 7:375-381.
13. John, G. T., M. Mathew, E. Snehaltha, V. Anandi, A. Date, C. K. Jacob, and J. C. M. Shastry. 1994. Cryptococcosis in renal allograft recipients. Transplantation 58:855-856.
14. Kontoyiannis, D. P., R. E. Lewis, N. Osherov, N. D. Albert, and G. S. May. 2003. Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species. J. Antimicrob. Chemother. 51:313-316.
15. Marchetti, O., P. Moreillon, M. P. Glauser, J. Bille, and D. Sanglard. 2000. Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans. Antimicrob. Agents Chemother. 44:2373-2381.
16. Odds, F. 2003. Synergy, antagonism, and what the checkerboard puts between them. J. Antimicrob. Chemother. 52:1.
17. Odom, A., S. Muir, E. Lim, D. L. Toffaletti, J. Perfect, and J. Heitman. 1997. Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J. 16:2576-2589.
18. Shaariah, W., Z. Morad, and A. B. Suleiman. 1992. Cryptococcosis in renal transplant recipients. Transplant. Proc. 24:1898-1899.
19. Singh, N., B. Alexander, O. Lortholary, F. Dromer, K. Gupta, G. John, R. del Busto, G. Klintmalm, J. Somani, G. Lyon, K. Pursell, V. Stosor, P. Munoz, A. K. A. Limaye, T. Pruett, J. Garcia-Diaz, A. Humar, S. Houston, A. House, D. Wray, S. Orloff, L. Dowdy, R. Fisher, J. Heitman, M. Wagener, S. Husain, and the Cryptococcal Collaborative Transplant Study Group. 2007. Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality. J. Infect. Dis. 195:756-764.
20. Singh, N., A. Limaye, G. Forrest, N. Safdar, P. Munoz, K. Pursell, S. Houston, F. Rosso, J. G. Montoya, P. Patton, R. del Busto, J. M. Aguado, R. A. Fisher, G. Klintmalm, R. Miller, M. M. Wagener, R. E. Lewis, D. P. Kontoyiannis, and S. Husain. 2006. Combination of voriconazole and caspofungin as primary therapy for invasive aspergillosis in solid organ transplant recipients: a prospective, multicenter observational trial. Transplantation 81:320-326.
21. Singh, N., and J. Perfect. 2007. Immune reconstitution syndrome associated with opportunistic mycoses. Lancet Infect. Dis. 7:395-401.
22. Steinbach, W. J., N. Singh, J. L. Miller, D. K. Benjamin, Jr., W. A. Schell, J. Heitman, and J. R. Perfect. 2004. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients. Antimicrob. Agents Chemother. 48:4922-4925.
23. Vilchez, R., J. Fung, and S. Kusne. 2002. Cryptococcosis in organ transplant recipients: an overview. Am. J. Transplant. 2:575-580.