Alpha and epsilon isozymes of protein kinase C in the chondrocytes in normal and early osteoarthritic articular cartilage

Calcified Tissue International

Volumn 58, Issue 3, 1996, Pages 192-194

  Satsuma, H ^a   Saito, N ^b   Hamanishi, C ^a   Hashima, M ^a   Tanaka, S ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Cartilage; Osteoarthritis; Protein kinase C

Indexed keywords

PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; ENZYME ACTIVATION; KNEE; MALE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RAT;

EID: 0029878008     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02526886     Document Type: Article

References (16)

1. Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308: 693-698
2. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and implications for cellular regulation. Nature 334: 661-665
3. Saito N, Osawa I, Itouji A, Koga T, Ikegaki N, Fukuda K, Saito A, Takaishi T, Sakai N, Hashimoto T, Nishino N, Tanaka C (1992) Protein kinase C family in neurons. Excerpta Medica 1027:75-83
4. Ono Y, Kikkawa U, Ogita K, Fujii T, Kurokawa T, Asaoka Y, Sekiguchi K, Ase K, Igarashi K, Nishizuka Y (1987) Expression and properties of two types of protein kinase C. Science 236:1116-1120
5. Bacher N, Zisman Y, Berent E, Livneh E (1991) Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. Mol Cell Biol 11:126-133
6. Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y (1989) Protein kinase C ζ subspecies from rat brain: its structure, expression and properties. Proc Natl Acad Sci USA 86: 3099-3103
7. Konno Y, Ohno S, Akita Y, Kawasaki H, Suzuki K (1989) Enzymatic properties of a novel phorbol ester/protein kinase, nPKC. J Biochem 106:673-678
8. Arner EC, Pratta MA (1991) Modulation of interleukin-1-induced alterations in cartilage proteoglycan metabolism by activation of protein kinase C. Arthritis Rheum 34:1006-1013
9. Kimura T, Hujioka H, Matsubara T, Itoh T (1994) The role of protein kinase C in glycosaminoglycan synthesis by cultured bovine articular chondrocytes. Clin Rheumatol (In Japanese) 5:240-246
10. Ito A, Saito N, Hirata M, Kose A, Tsujino T, Yosihara C, Ogita K, Kishimoto A, Nishizuka Y, Tanaka C (1990) Immunocytochemical localization of the subspecies of protein kinase C in rat brain. Proc Natl Acad Sci USA 87:3195-3199
11. Koide H, Ogita K, Kikkawa U, Nishizuka Y (1992) Isolation and characterization of the ε subspecies of protein kinase C in rat brain. Proc Natl Acad Sci USA 89:1146-1153
12. Saito N, Itouji A, Totani Y, Osawa I, Koide H, Fujisawa N, Ogota K, Tanaka C (1993) Cellular and intracellular localization of ε subspecies of protein kinase C in rat brain: presynaptic localization of the e subspecies. Brain Res 607:241-248
13. Saito N, Kose A, Ito A, Hosoda K, Mori M, Hirata M, Ogita K, Kikkawa U, Ono Y, Igarashi K, Nishizuka Y, Tanaka C (1989) Immunocytochemical localization of the βII subspecies of protein kinase C in rat brain. Proc Natl Acad Sci USA 86:3409-3413
14. Hashimoto T, Ase K, Sawamura S, Kikkawa U, Saito N, Tanaka C, Nishizuka Y (1988) Postnatal development of a brain-specific subspecies of protein kinase C in rat. J Neurosci 8:1678-1683
15. Mochly-Rosen D (1995) Localization of protein kinase by anchoring proteins: a theme in signal transduction. Science 268:247-251
16. Papadopoulos V, Hall PF (1989) Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton. J Cell Biol 108:553-567