Downregulation of arginase II and renal apoptosis by inorganic mercury: Overexpression of arginase II reduces its apoptosis

Archives of Toxicology

Volumn 82, Issue 2, 2008, Pages 67-73

  Kanda, Hironori ^a   Kikushima, Makoto ^a   Homma Takeda, Shino ^a,c   Sumi, Daigo ^a   Endo, Akiko ^a   Toyama, Takashi ^a   Miura, Nobuhiko ^b   Naganuma, Akira ^b   Kumagai, Yoshito ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Accumulation; Apoptosis; Arginase II; Inorganic mercury; Proximal tubule

Indexed keywords

ARGINASE; ARGINASE 2; MERCURY; MERCURY CHLORIDE; NITRIC OXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; ARGINASE; DNA FRAGMENTATION; DOWN-REGULATION; KIDNEY; LLC-PK1 CELLS; MALE; MERCURIC CHLORIDE; RATS; RATS, WISTAR; SWINE; TIME FACTORS;

RATTUS;

EID: 38649111052     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0244-z     Document Type: Article

References (29)

1. Baranczyk-Kuzma A, Porembska Z, Mochnacka I (1976) Oligomeric structure of A1 arginase from rat liver and A4 from kidney: difference in charge of subunits. Acta Biochim Pol 23:151-163
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
3. Buzard GS, Kasprzak KS (2000) Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review. J Environ Pathol Toxicol Oncol 19:179-199
4. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
5. Clarkson TW (1972) The pharmacology of mercury compounds. Annu Rev Pharmacol 12:375-406
6. Conrad KP, Joffe GM, Kruszyna H, Kruszyna R, Rochelle LG, Smith RP, Chavez JE, Mosher MD (1993) Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J 7:566-571
7. Duncan-Achanzar KB, Jones JT, Burke MF, Carter DE, Laird HE II (1996) Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1. J Pharmacol Exp Ther 277:1726-1732
8. Esch F, Lin KI, Hills A, Zaman K, Baraban JM, Chatterjee S, Rubin L, Ash DE, Ratan RR (1998) Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. J Neurosci 18:4083-4095
9. Estévez AG, Sahawneh MA, Lange PS, Bae N, Egea M, Ratan RR (2006) Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons. J Neurosci 26:8512-8516
10. Gwinner W, Deters-Evers U, Brandes RP, Kubat B, Koch KM, Pape M, Olbricht CJ (1998) Antioxidant-oxidant balance in the glomerulus and proximal tubule of the rat kidney. J Physiol 509:599-606
11. Gotoh T, Mori M (1999) Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol 144:427-434
12. Gotoh T, Sonoki T, Nagasaki A, Terada K, Takiguchi M, Mori M (1996) Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. FEBS Lett 395:119-122
13. Homma-Takeda S, Takenaka Y, Kumagai Y, Shimojo N (1999) Selective induction of apoptosis of renal proximal tubular cells caused by inorganic mercury in vivo. Environ Toxicol Phar 7:179-187
14. Iyer RK, Bando JM, Jenkinson CP, Vockley JG, Kim PS, Kern RM, Cederbaum SD, Grody WW (1998) Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab 63:168-175
15. Jansen A, Lewis S, Cattell V, Cook HT (1992) Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli. Kidney Int 42:1107-1112
16. Kanda H, Kumagai Y, Nakajima H, Takenaka Y, Homma-Takeda S, Shimojo N (1998) Various changes in nitric oxide synthase and arginase II in rat kidney caused by inorganic mercury. Sangyo Eiseigaku Zasshi 40:212-213
17. Kaysen GA, Strecker HJ (1973) Purification and properties of arginase of rat kidney. Biochem J 133:779-788
18. Kroll DJ, Graichen ME, Leonard TB (1988) Strain difference in rat renal microsomal epoxide hydrolase elevation after mercuric chloride treatment. Carcinogenesis 9:193-198
19. Kumagai Y, Homma-Takeda S, Shinyashiki M, Shimojo N (1997) Alterations in superoxide dismutase isozymes by methylmercury. Appl Organometal Chem 11:635-643
20. Liang M, Knox FG (2000) Production and functional roles of nitric oxide in the proximal tubule. Am J Physiol Regul Integr Comp Physiol 278:R1117-R1124
21. Miyanaka K, Gotoh T, Nagasaki A, Takeya M, Ozaki M, Iwase K, Takiguchi M, Iyama KI, Tomita K, Mori M (1998) Immunohistochemical localization of arginase II and other enzymes of arginine metabolism in rat kidney and liver. Histochem J 30:741-751
22. Ozaki M, Gotoh T, Nagasaki A, Miyanaka K, Takeya M, Fujiyama S, Tomita K, Mori M (1999) Expression of arginase II and related enzymes in the rat small intestine and kidney. J Biochem (Tokyo) 125:586-593
23. Phillips R, Yamauchi M, Côté MG, Plaa GL (1977) Assessment of mercuric chloride-induced nephrotoxicity by p-aminohippuric acid uptake and the activity of four gluconeogenic enzymes in rat renal cortex. Toxicol Appl Pharmacol 41:407-422
24. Shenker BJ, Guo TL, Shapiro IM (2000) Mercury-induced apoptosis in human lymphoid cells: evidence that the apoptotic pathway is mercurial species dependent. Environ Res 84:89-99
25. Shinyashiki M, Kumagai Y, Nakajima H, Nagafune J, Homma-Takeda S, Sagai M, Shimojo N (1998) Differential changes in rat brain nitric oxide synthase in vivo and in vitro by methylmercury. Brain Res 798:147-155
26. Slyke DDV, Archibald RM (1946) Gasometric and photometric measurement of arginase activity. J Biol Chem 165:293-309
27. Weinberg JM, Harding PG, Humes HD (1982) Mitochondrial bioenergetics during the initiation of mercuric chloride-induced renal injury: I. Direct effects of in vitro mercuric chloride on renal mitochondrial function. J Biol Chem 257:60-67
28. Yu Y, Terada K, Nagasaki A, Takiguchi M, Mori M (1995) Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: expression of the enzymes in rat tissues. J Biochem (Tokyo) 117:952-957
29. Zalups PK (2000) Molecular interactions with mercury in the kidney. Pharmacol Rev 52:113-143