Valproic acid alters GnRH-GABA interactions in cycling female rats

Cellular and Molecular Neurobiology

Volumn 27, Issue 8, 2007, Pages 1069-1083

  Lakhanpal, Dinesh ^a   Kaur, Gurcharan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

Author keywords

Antiepileptic drugs; Epilepsy; GnRH pulse generator; Hypothalamus; Neuronal plasticity; Valproic acid

Indexed keywords

4 AMINOBUTYRIC ACID; GONADORELIN; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; BODY WEIGHT; BRAIN REGION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; EPILEPSY; ESTRUS CYCLE; FEMALE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MENSTRUAL CYCLE; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALS; ESTROUS CYCLE; FEMALE; GAMMA-AMINOBUTYRIC ACID; GONADOTROPIN-RELEASING HORMONE; NEURAL CELL ADHESION MOLECULE L1; NEURONS; OVARY; RATS; RATS, WISTAR; SIALIC ACIDS; VALPROIC ACID;

RATTUS;

EID: 38649107716     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-007-9201-x     Document Type: Conference Paper

References (42)

1. Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E (1978) Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science 202:631-633
2. Bergen HT, Hejtmancik JF, Pfaff DW (1991) Effects of gamma-aminobutyric acid receptor agonists and antagonist on LHRH-synthesizing neurons as detected by immunocytochemistry and in situ hybridization. Exp Brain Res 87:46-56
3. Betts T, Yarrow H, Dutton N, Greenhill L, Rolfe TA (2003) Study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. Seizure 12:323-329
4. Bilger M, Heger S, Brann DW, Paredes A, Ojeda SR (2001) A conditional tetracycline-regulated increase in Gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat. Endocrinology 142:2102-2114
5. Bohme I, Luddens H (2001) The inhibitory neural circuitry as target of antiepileptic drugs. Curr Med Chem 8:1257-1274
6. Cook JS, Bale JF, Hoffman RP (1992) Pubertal arrest associated with valproic acid therapy. Pediatr Neurol 8:229-231
7. Czapinski P, Blaszczyk B, Czuczwar SJ (2005) Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 5:3-14
8. Dodge JC, Illig AM, Snyder PJ, Badura LL (2000) GABA levels within the medial preoptic area: effects of chronic administration of sodium valproic acid. Psychoneuroendocrinology 25:519-534
9. Feleder C, Jarry H, Leonhardt S, Wuttke W, Moguilevsky JA (1996) The GABAergic control of gonadotropin-releasing hormone secretion in male rats during sexual maturation involves effects on hypothalamic excitatory and inhibitory amino acid systems. Neuroendocrinology 64:305-312
10. Fryer HJ, Hockfield S (1996) The role of polysialic acid and other carbohydrate polymers in neural structural plasticity. Curr Opin Neurobiol 6:113-118
11. Glass JD, Shen H, Fedorkova L, Chen L, Tomasiewicz H, Watanabe M (2000) Polysialylated neural cell adhesion molecule modulates photic signaling in the mouse suprachiasmatic nucleus. Neurosci Lett 280:207-210
12. Harris GC, Levine JE (2003) Pubertal acceleration of pulsatile gonadotropin-releasing hormone release in male rats as revealed by microdialysis. Endocrinology 144:163-171
13. Harvey PK, Bradford HF, Davison AN (1975) The inhibitory effect of sodium n-dipropyl acetate on the degradative enzymes of the GABA shunt. FEBS Lett 52:251-254
14. Herbison AE, Dyer RG (1991) Effect on luteinizing hormone secretion of GABA receptor modulation in the medial preoptic area at the time of proestrous luteinizing hormone surge. Neuroendocrinology 53:317-320
15. Illig AM, Melia K, Snyder PJ, Badura LL (2000) Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice. Brain Res 885:192-200
16. Isojarvi JIT, Tauboll E, Herzog AG (2005) Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs 19:207-223
17. Isojarvi JI, Tauboll E, Pakarinen AJ, van Parys J, Rattya J, Harbo HF, Dale PO, Fauser BC, Gjerstad L, Koivunen R, Knip M, Tapanainen JS (2001) Altered ovarian function and cardiovascular risk factors in valproate-treated women. Am J Med 111:290-296
18. Kaplan PW (2004) Reproductive health effects and teratogenicity of antiepileptic drugs. Neurology 63:S13-S23
19. Kaur G, Heera PK, Srivastava LK (2002) Neuroendocrine plasticity in GnRH release during rat estrous cycle: correlation with molecular markers of synaptic remodeling. Brain Res 95:421-431
20. Kemp LI (1992) Br Sodium valproate as an antidepressant. J Psychiatry 160:121-123
21. King JC, Ronsheim PM, Rubin BS (1995) Dynamic relationships between LHRH neuronal terminals and the end-feet of tanycytesin cycling rats revealed by confocal microscopy. Proceedings of the 25th Annual Meeting of the Society for Neuroscience Abstract 21:265
22. Laeng P, Pitts RL, Lemire AL, Drabik CE, Weiner A, Tang H, Thyagarajan R, Mallon BS, Altar CA (2004) The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. J Neurochem 91:238-251
23. Lamberts R, Vijayan E, Graf M, Mansky T, Wuttke W (1983) Involvement of preoptic-anteriorhypothalamic GABA neurons in the regulation of pituitary LH and prolactin release. Exp Brain Res 52:356-362
24. Leranth C, MacLusky NJ, Sakamoto H, Shanabrough M, Naftolin F (1985) Glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area. Neuroendocrinology 40:536-539
25. McElroy SL, Keck PE Jr, Pope HG Jr, Hudson JI (1992) Valproate in the treatment of bipolar disorder: literature review and clinical guidelines. J Clin Psychopharmacol 12:42S-52S
26. Morrell MJ, Giudice L, Flynn KL, Seale CG, Paulson AJ, Done S, Flaster E, Ferin M, Sauer MV (2002) Predictors of ovulatory failure in women with epilepsy. Ann Neurol 52:704-711
27. Owens MJ, Nemeroff CB (2003) Pharmacology of valproate. Psychopharmacol Bull 37:17-24
28. Parkash J, Kaur G (2005) Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule. J Endocrinol 186:397-409
29. Rattya J, Pakarinen AJ, Knip M, Repo-Outakoski M, Myllyla VV, Isojarvi JI (2001) Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. Neurology 57:440-444
30. Rekling JC (2003) Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation. Neurosci Lett 335:167-170
31. Roste LS, Tauboll E, Berner A, Isojarvi JI, Gjerstad L (2001) Valproate, but not lamotrigine, induces ovarian morphological changes in Wistar rats. Exp Toxicol Pathol 52:545-552
32. Roste LS, Tauboll E, Isojarvi JI, Pakarinen AJ, Huhtaniemi IT, Knip M, Gjerstad L (2002) Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats. Reprod Toxicol 16(6):767-773
33. Roste LS, Tauboll E, Morkrid L, Bjornenak T, Saetre ER, Morland T, Gjerstad L (2005) Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. Eur J Neurol 12:118-124
34. Rutishauser U, Landmesser L (1996) Polysialic acid in the vertebrate nervous system: a promoter of plasticity in cell-cell interactions. Trends Neurosci 19:422-427
35. Scott CJ, Clarke IJ (1993) Evidence that changes in the function of the subtypes of the receptors for gamma-amino butyric acid may be involved in the seasonal changes in the negative-feedback effects of oestrogen on gonadotropin-releasing hormone secretion and plasma luteinizing hormone levels in the ewe. Endocrinology 133:2904-2912
36. Seki T, Arai Y (1991) Expression of highly polysialylated NCAM in the neocortex and piriform cortex of the developing and the adult rat. Anat Embryol 184:395-401
37. Seki T, Arai Y (1993) Highly polysialylated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat. J Neurosci 13:2351-2358
38. Sisk CL, Richardson HN, Chappell PE, Levine JE (2001) In vivo gonadotropin-releasing hormone secretion in female rats during peripubertal development and on proestrus. Endocrinology 142:2929-2936
39. Snyder PJ, Badura LL (1998) A potential mechanism of slowed pubertal maturation after chronic administration of sodium valproic acid. Neurology 50:922-925
40. Svalheim S, Tauboll E, Bjornenak T, Roste LS, Morland T, Saetre ER, Gjerstad L (2003) Do women with epilepsy have increased frequency of menstrual disturbances? Seizure 12:529-533
41. Tauboll E, Isojarvi JI, Harbo HF, Pakarinen AJ, Gjerstad L (1999) Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats. Seizure 8:490-493
42. Watanabe G, Terasawa E (1989) In vivo release of luteinizing hormone releasing hormone increases with puberty in the female rhesus monkey. Endocrinology 125:92-99