Long-term valproate treatment induces changes in ovarian morphology and serum sex steroid hormone levels in female Wistar rats

Seizure

Volumn 8, Issue 8, 1999, Pages 490-493

  Taubøll, Erik ^a   Isojärvi, Jouko I T ^b   Harbo, Hanne Flinstad ^a   Pakarinen, Arto J ^b   Gjerstad, Leif ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

Estrogen; Polycystic ovaries; Rats; Testosterone; Valproate

Indexed keywords

ANTICONVULSIVE AGENT; ESTROGEN; PROGESTERONE; SEX HORMONE; TESTOSTERONE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOCRINE FUNCTION; ESTROGEN BLOOD LEVEL; FEMALE; FOLLICLE CYST; NONHUMAN; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RAT; TESTOSTERONE BLOOD LEVEL;

EID: 0343920741     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1053/seiz.1999.0342     Document Type: Article

References (10)

1. Isojärvi J. I. T., Laatikainen T. J., Pakarinen A. J., Juntunen K. T. S., Myllylä V. V. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. New England Journal of Medicine. 329:1993;1383-1388.
2. Isojärvi J. I. T., Laatikainen T. J., Knip M., Pakarinen A. J., Juntunen K. T. S., Myllylä V. V. Obesity and endocrine disorders in women taking valproate for epilepsy. Annals of Neurology. 39:1996;579-584.
3. Isojärvi J. I. T., Taubøll E., Dale P. O., et al. Polycystic ovaries in women taking valproate monotherapy for epilepsy: a two-center study. Epilepsia. 38 (Suppl. 8):1997;102.
4. Morrell M. J., Springer E., Guidice L. Reproductive function in women with epilepsy on inducing and noninducing antiepileptic drugs. Epilepsia. 38 (Suppl. 8):1997;232.
5. Herzog A. G., Seibel M. M., Schomer D. L., Vaitukaitis J. L., Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Archives of Neurology. 43:1986;341-346.
6. Bilo L., Meo R., Nappi C., et al. Reproductive endocrine disorders in women with primary generalized epilepsy. Epilepsia. 29:1988;612-619.
7. Isojärvi J. I. T., Rättyä J., Myllylä V. V., et al. Valproate, lamotrigine and insulin-mediated risks in women with epilepsy. Annals of Neurology. 43:1998;446-451.
8. J. I. T. Isojärvi, E. Taubøll, A. J. Pakarinen, et al.
9. Walker R. M., Smith G. S., Barsoum N. J., Macallum G. E. Preclinical toxicology of the anticonvulsant calcium valproate. Toxicology. 63:1990;137-155.
10. E. Taubøll, J. M. Nesland, F. H. Harbo, J. I. T. Isojärvi, L. Gjerstad, Proceedings of the Third European Congress of Epileptology, Majkowski, J.Owczarek, K.Zwolinski, P. 1998, Monduzzi Editore, Bologna, Italy, 49, 53.