Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine

Fundamental and Clinical Pharmacology

Volumn 22, Issue 1, 2008, Pages 19-23

  Strolin Benedetti, M ^a   Whomsley, R ^a   Mathy, F X ^a   Jacques, P ^a   Espie, P ^a   Canning, M ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Dextrocetirizine; Levocetirizine; Renal tubular secretion

Indexed keywords

CARBON 14; CETIRIZINE; DEXTROCETIRIZINE; HISTAMINE H1 RECEPTOR ANTAGONIST; LEVOCETIRIZINE; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG PROTEIN BINDING; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; ISOTOPE LABELING; KIDNEY CLEARANCE; KIDNEY TUBULE EXCRETION; LIQUID SCINTILLATION COUNTING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; URINARY EXCRETION;

ADULT; BLOOD PROTEINS; CETIRIZINE; FEMALE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; KIDNEY TUBULES; MALE; MIDDLE AGED; PIPERAZINES; STEREOISOMERISM;

EID: 38649104109     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2007.00543.x     Document Type: Article

References (23)

1. Hewitt W.R., Hook J.B. The renal excretion of drugs, in: Bridges J.W., Chasseaud L.F. (Eds Progress in drug metabolism, vol.7, John Wiley & Sons Ltd., New York, 1983, pp. 11 56.
2. Lesne M. Les bases pharmacocinétiques de l'adaptation posologique des médicaments dans l'insuffisance rénale. J. Pharm. Belg. (1988) 43 212 232.
3. Bonate P.L., Reith K., Weir S. Drug interactions at the renal level. Implications for drug development. Clin. Pharmacokin. (1998) 34 375 404.
4. Roland M., Tozer T.N. Elimination, in: Robert D. Magee (Ed Clinical pharmacokinetics. Concepts and applications, 3rd edn, William & Wilkins, Media, PA, 1995, pp. 156 183.
5. Van Montfoort J.E., Hagenbuch B., Groothuis G.M.M., Koepsell H., Meier P.J., Meijer D.K.F. Drug uptake systems in liver and kidney. Curr. Drug Metab. (2003) 4 185 211.
6. Li M., Anderson G.D., Wang J. Drug-drug interactions involving membrane transporters in the human kidney. Expert Opin. Drug Metab. (2006) 2 505 532.
7. 14C-cetirizine in humans. Ann. Allergy (1987) 59 31 34.
8. Sasa M., Naito M., Kojima T. Pharmacokinetics of single and multiple doses of a new antiallergic drug, cetirizine, and examination of its safety. Jpn J. Clin. Pharmacol. Ther. (1995) 26 509 522.
9. Whomsley R., Strolin Benedetti M., Baltes E. Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency. Clin. Pharmacol. Ther. (2006) 80 715 716.
10. 1) antagonists. Allergy (1995) 50 12 16.
11. 194. Mol. Pharmacol. (2002) 61 1 9.
12. 1-receptor antagonists. Biochem. Pharmacol. (2003) 66 1123 1126.
13. Wang D.Y., Hanotte F., De Vos C., Clement P. Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. Allergy (2001) 56 339 343.
14. Baltes E., Coupez R., Giezek H., Voss G., Meyerhoff C., Strolin Benedetti M. Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam. Clin. Pharmacol. (2001) 15 269 277.
15. 1-receptor antagonist, in humans. Fundam. Clin. Pharmaocol. (2002) 16 471 478.
16. Gupta A., Hammarlund-Udenaes M., Chatelain P., Massingham R., Jonsson E.N. Stereoselective pharmacokinetics of cetirizine in the guinea pig: role of protein binding. Biopharm. Drug Dispos. (2006) 27 291 297.
17. th ERS Congress, Glasgow, September 2004. Eur. Respir. J. (2004) 24 129s P871.
18. Itoh T., Ishida M., Onuki Y., Tsuda Y., Shimada H., Yamada H. Stereoselective renal tubular secretion of carbenicillin. Antimicrob. Agents Chemother. (1993) 37 2327 2332.
19. Itoh T., Watanabe N., Ishida M., Tsuda Y., Koyano S., Tsunoi T., Shimada H., Yamada H. Stereoselective disposition of sulbenicillin in humans. Antimicrob. Agents Chemother. (1998) 42 325 331.
20. Notterman D.A., Drayer D.E., Metakis L., Reidenberg M.M. Stereoselective renal tubular secretion of quinidine and quinine. Clin. Pharmacol. Ther. (1986) 40 511 517.
21. Lima J.J., Boudoulas H., Shields J. Stereoselective pharmacokinetics of disopyramide enantiomers in man. Drug. Metab. Dispos. (1985) 13 572 577.
22. Robbins D.K, Castles M.A., Pack D.J., Bhargava V.O., Weir S.J. Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers. Biopharm. Drug Dispos. (1998) 19 455 463.
23. Bow D.A., Perry J.L., Simon J.D., Pritchard J.B. The impact of plasma protein binding on the renal transport of organic anions. J. Pharmacol. Exp. Ther. (2006) 316 349 355.