Aggressive natural killer cell leukemia presenting with hemophagocytic lymphohistiocytosis

Pediatric Blood and Cancer

Volumn 50, Issue 3, 2008, Pages 654-657

  Petterson, Toni E ^a   Bosco, Annmarie A ^b   Cohn, Richard J ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Acute; Epstein Barr virus; Histiocytosis; Leukemias; Pediatric hematology oncology

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CYCLOSPORIN; DEXAMETHASONE; ETOPOSIDE;

ABDOMINAL PAIN; AGGRESSIVE NATURAL KILLER CELL LEUKEMIA; ANOREXIA; ANTIBIOTIC THERAPY; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME 6; CHROMOSOME 7; CONSTIPATION; CYTOGENETICS; EPSTEIN BARR VIRUS; FEBRILE NEUTROPENIA; FEVER; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HEPATOSPLENOMEGALY; HUMAN; IMMUNOPHENOTYPING; LETHARGY; LEUKEMIA; MALE; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL;

ANEUPLOIDY; ANTIGENS, CD8; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 7; DISEASE PROGRESSION; EPSTEIN-BARR VIRUS INFECTIONS; FATAL OUTCOME; HUMANS; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MULTIPLE ORGAN FAILURE; OPPORTUNISTIC INFECTIONS;

EID: 38549175650     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21358     Document Type: Article

References (20)

1. Ruskova AK, Thula R, Chan GTC. Aggressive natural killer-cell leukemia: Report of five cases and review of the literature. Leuk Lymphoma 2004;45:2427-2438.
2. Osuji N, Matutes E, Morilla A, et al. Prolonged treatment response in aggressive natural killer cell leukemia. Leuk Lymphoma 2005;46:757-763.
3. Shimodaira S, Ishida F, Kobayashi H, et al. The detection of clonal proliferation in granular lymphocyte-proliferative disorders of natural killer cell lineage. Br J Haematol 1995;90:578-584.
4. Kuroda J, Kimura S, Kobayashi Y, et al. Variable manifestation in natural killer cell leukaemia. Clin Lab Haematol 2003;25:239-245.
5. Kwong YL, Chan ACL, Liang RHS. Natural killer cell lymphoma/leukemia: Pathology and treatment. Hematol Oncol 1997;15:71-79.
6. Makishima H, Ito T, Asano N, et al. Significance of chemokine receptor expression in aggressive NK cell leukemia. Leukemia 2005;19:1169-1174.
7. Treatment Protocol of the Second International HLH Study 2004. Histiocyte Society; Sweden.
8. Chan JKC, Wong KF, Jaffe ES, Ralfkiaer E. Aggressive NK-cell leukaemia. In: Jaffe ES, Harris NL, Stein H, Vardiamn JW, editors. World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001. pp 198-200.
9. Okuda T, Sakamoto S, Deguchi T, et al. Hemophagocytic syndrome associated with aggressive natural killer cell leukemia. Am J Hematol 1991;155:1419-1425.
10. Chan JKC, Sin VC, Wong KF, et al. Nonnasal lymphoma expressing the natural killer cell marker C D56: A clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. Blood 1997;89:4510-4513.
11. Mori KL, Egashira M, Oshimi K. Differentiation stage of natural killer cell-lineage lymphoproliferative disorders based on phenotypic analysis. Br J Haematol 2001;115:225-228.
12. Wong KF, Zhang YM, Chan JKC. Cytogenetic abnormalities in natural killer cell lymphoma/leukemia - is there a consistent pattern? Leuk Lymphoma 1999;34:241-250.
13. Siu LLP, Wong KF, Chan JKC, Kwong YL. Comparative genomic hybridisation analysis of natural killer cell lymphoma/leukemia. Am J Pathol 1999;155:1419-1425.
14. Lin M, Chang H, Huang C, et al. Massive expansion of EBV+ monoclonal T cells with CD5 down regulation in - EBV associated haemophagocytic lymphohistiocytosis. J Clin Path 2007;60:101-103.
15. Tsang WYW, Chan JKC, Yip TTC, et al. In situ localisation of Epstein-Barr virus encoded RNA in non-nasal/nasopharyngeal CD 56-positive and CD 56-negative T-cell lymphomas. Hum Pathol 1994;25:758-765.
16. Mizuno S, Akashi K, Ohshima K, et al. Interferon-γ prevents apoptosis in Epstein-Barr virus-infected natural killer cell leukemia in an autocrine fashion. Blood 1999;93:3494-3504.
17. Ohshima K, Kikuchi M, Mizuno S, et al. Hepatosinusoidal leukemia/lymphoma consisting of Epstein-Barr virus-containing natural killer cell leukemia/lymphoma and T-cell lymphoma: Mimicking malignant histiocytosis. Hematol Oncol 1995;13: 83-97.
18. Kanegane H, Miyawaki T, Yachie A, et al. Development of EBV-positive T-cell lymphoma following infection of peripheral blood T cells with EBV. Leuk Lymphoma 1999;34: 603-607.
19. Tsuchiya S. Diagnosis of Epstein-Barr virus-associated diseases. Crit Rev Oncol Hematol 2002;44:227-238.
20. Nava VE, Jaffe ES. The pathology of NK-cell lymphomas and leukemias. Anat Pathol 2005;12:27-34.