Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 12, 2007, Pages 5377-5387

  Ruiz, Alberto ^a,b   Ghyselinck, Norbert B ^c,d   Mata, Nathan ^e   Nusinowitz, Steven ^a   Lloyd, Marcia ^a   Dennefeld, Christine ^c   Chambon, Pierre ^c,d   Bok, Dean ^a,b  

^a JULES STEIN EYE INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CNRS   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

^e Sirion Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; RETINOID; RETINOL ESTER; TYROSINASE RELATED PROTEIN 1; ACYLTRANSFERASE; INTEGRASE; LECITHIN RETINOL ACYLTRANSFERASE; LECITHIN-RETINOL ACYLTRANSFERASE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAM; EXON; GENE; GENE ACTIVITY; GENE DISRUPTION; GENE EXPRESSION; HETEROZYGOSITY; KNOCKOUT MOUSE; LRAT GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; ELECTRORETINOGRAPHY; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC RECOMBINATION; GENETICS; GENOTYPE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACYLTRANSFERASES; ANIMALS; BLOTTING, WESTERN; ELECTRORETINOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; GENOTYPE; INTEGRASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PIGMENT EPITHELIUM OF EYE; RECOMBINATION, GENETIC; RETINA; RETINOIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 38549174686     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0673     Document Type: Article

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