Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model

Journal of Experimental and Clinical Cancer Research

Volumn 26, Issue 4, 2007, Pages 483-487

  Spugnini, Enrico P ^a,d   Dotsinsky, I ^d   Mudrov, N ^d   Cardosi, G ^c   Citro, G ^a   D'Avino, A ^b   Baldi, A ^b  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c Freelance   (Italy)

^d CENTRE OF BIOMEDICAL ENGINEERING   (Bulgaria)

Author keywords

Adenoma; Biphasic pulses; Carcinoma; Dog; Electrochemotherapy

Indexed keywords

BLEOMYCIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANUS CARCINOMA; ARTICLE; CANCER CHEMOTHERAPY; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); DISEASE COURSE; DOG; DRUG EFFICACY; DRUG PULSE THERAPY; ELECTROCHEMOTHERAPY; ELECTRODE; INJECTION; MALE; NEEDLE; NONHUMAN; OUTCOME ASSESSMENT; PERIANAL GLAND; PET ANIMAL; PRIORITY JOURNAL; RECTUM ADENOMA; SEDATION;

ANAL GLAND NEOPLASMS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; COMBINED MODALITY THERAPY; DOG DISEASES; DOGS; ELECTROCHEMOTHERAPY; FEMALE; MALE; MODELS, ANIMAL;

EID: 38549156107     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Nielsesn S.W., Aftosmis J.: Canine perianal gland tumors. J. Am. Vet. Med. Assoc. 144: 127-135, 1964.
2. McGavin M.D., Fishburn F.: Perianal adenoma of apocrine origin in a dog. J. Am. Vet. Med. Assoc. 166: 388-389, 1975.
3. Isitor G.N.: Comparative ultrastructural study of normal, adenomatous, carcinomatous, and hyperplastic cells of canine hepatoid circumanal gland. Am. J. Vet. Res. 44: 463-474, 1983.
4. Turek M.M., Withrow S.J.: Perianal Tumors. In: Withrow S.J., Vail D.M., eds. Small animal clinical oncology. 4rd ed. New York; WB Saunders Co, 2007; 503-510.
5. Hayes H.M. Jr., Wilson G.P.: Hormone-dependent neoplasms of the canine perianal gland. Cancer Res. 37: 2068-2071, 1977.
6. Wilson G.P., Hayes H.M. Jr.: Castration for treatment of perianal gland neoplasms in the dog. J. Am. Vet. Med. Assoc. 174: 1301-1303, 1979.
7. Chaisiri N., Pierrpoint C.G.: Steroid-receptor interaction in a canine anal adenoma. J. Small. Animal. Pract. 20: 405-416, 1979.
8. Dow S.W., Olson P.N., Rosychuk R.A., Withrow S.J.: Perianal adenomas and hypertestosteronemia in a spayed bitch with pituitary-dependent hyperadrenocorticism. J. Am. Vet. Med. Assoc. 192: 1439-1441, 1988.
9. Hill K.E., Scott-Moncrieff J.C., Koshko M.A., Glickman L.T., Glickman N.W., Nelson R.W., Blevins W.E., Oliver J.W.: Secretion of sex hormones in dogs with adrenal dysfunction. J. Am. Vet. Med. Assoc. 226: 556-561, 2005.
10. Hitt R.E.: Removal of perianal neoplasms. J. Am. Vet. Med. Assoc. 175: 658, 1979.
11. Liska W.D.: Anorectal and perianal cryosurgery. Vet. Clin. North Am. Small. Anim. Pract. 10: 803-820, 1980.
12. Grier R.L., Brewer W.G. Jr., Theilen G.H.: Hyperthermic treatment of superficial tumors in cats and dogs. J. Am. Vet. Med. Assoc. 177: 227-233, 1980.
13. Anderson C.R., McNiel E.A., Gillette E.L., Powers B.E., LaRue S.M.: Late complications of pelvic irradiation in 16 dogs. Vet. Radiol. Ultrasound 43:187-192, 2002.
14. Owen L.N.: 1980. TNM classification of tumours in domestic animals, World Health Organization, Geneva.
15. Daskalov I., Mudrov N., Peycheva E.: Exploring new instrumentation parameters for electrochemotherapy. IEEE Engineering in. Medicine and Biology 18: 62-66, 1999.
16. Peycheva E., Daskalov I., Tsoneva I.: Electrochemotherapy of mycosis fungoides by interferon-α. Bioelectrochemistry.70:283-286, 2007.
17. Spugnini E.P., Porrello A.: Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses. J. Exp. Clin. Cancer Res. 22: 571-580, 2003.
18. Spugnini E..P, Citro G., Porrello A.: Rational design of new electrodes for electrochemotherapy. J. Exp. Clin. Cancer Res. 24: 245-254, 2005.
19. Spugnini E.P., Dragonetti E., Vincenzi B., Onori N., Citro G., Baldi A.: Pulse mediated chemotherapy enhances local control and survival in a spontaneous canine model of primary mucosal melanoma. Melanoma Res 16: 23-27, 2006.
20. Spugnini E.P., Baldi A., Vincenzi B., Bongiorni F., Bellelli C., Porrello A.: Intraoperative versus postoperative electrochemotherapy in soft tissue sarcomas: a preliminary study in a spontaneous feline model. Cancer Chemother. Pharmacol. 59: 375-381, 2007.
21. Baldi A., Spugnini E.P.: Thoracic haemangiopericytoma in a cat. Vet Rec. 159: 598-600, 2006.
22. Spugnini E.P., Vincenzi B., Baldi F., Citro G., Baldi A.: Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Res. 26 (6B): 4585-4589, 2006.
23. Spugnini E.P., Vincenzi B., Citro G., Santini D., Dotsinsky I., Mudrov N., Baldi A.: Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas. In Vivo 21: 819-822, 2007.
24. Spugnini E.P., Filipponi M., Romani L., Dotsinsky I., Mudrov N., Barone A., Rocco E., Laieta M.T., Montesarchio V., Cassano R., Citro G., Baldi A.. Local control and distant metastasis after electrochemotherapy of a canine anal melanoma. In Vivo 21: 897-899, 2007.
25. Spugnini E.P., Vincenzi B., Citro G., Tonini G., Dotsinsky I., Mudrov N., Baldi A.: Electrochemotherapy for the treatment of squamous cell carcinoma in cats: A preliminary report. Vet. J., in press.
26. Spugnini E.P., Citro G., Dotsinsky I., Mudrov N., Mellone P., Baldi A.: Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. Vet. J., in press.
27. Spugnini E.P., Citro G., Mellone P., Dotsinsky I., Mudrov N., Baldi A.: Electrochemotherapy for localized lymphoma: a preliminary study in companion animals. J. Exp. Clin. Cancer Res. 26: 343-346, 2007.
28. Tozon N., Kodre V., Sersa G., Cemazar M.: Effective treatment of perianal tumors in dogs with electrochemotherapy. Anticancer Res. 25: 839-845, 2005.