Exploring new instrumentation parameters for electrochemotherapy: Attacking tumors with bursts of biphasic pulses instead of single pulses

IEEE Engineering in Medicine and Biology Magazine

Volumn 18, Issue 1, 1999, Pages 62-66

  Daskalov, Ivan ^a   Mudrov, N ^b   Peycheva, E ^b  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; ELECTRIC IMPEDANCE; ELECTRIC POTENTIAL; ONCOLOGY; WAVEFORM ANALYSIS;

ELECTROCHEMOTHERAPY;

ELECTROTHERAPEUTICS;

BASAL CELL CARCINOMA; BIOMEDICAL ENGINEERING; CANCER RESEARCH; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCHEMOTHERAPY; ELECTRONICS; HUMAN; REVIEW; SQUAMOUS CELL CARCINOMA;

ANTIMETABOLITES, ANTINEOPLASTIC; BLEOMYCIN; CARCINOMA, BASAL CELL; COMBINED MODALITY THERAPY; ELECTRIC STIMULATION THERAPY; EQUIPMENT DESIGN; EQUIPMENT SAFETY; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MELANOMA; NEOPLASM RECURRENCE, LOCAL; REMISSION INDUCTION; SKIN NEOPLASMS;

EID: 0032940731     PISSN: 07395175     EISSN: None     Source Type: Journal    
DOI: 10.1109/51.740982     Document Type: Review

References (18)

1. Dev SB, Hofmann GA: Electrochemotherapy - a novel method of cancer treatment. Cancer Treatment Reviews, 20: 105-115, 1994.
2. Mir LM, Orlowski S, Belehradek J, Eissie J, Rols MP, Sersa G, Miklavcic D, Gilbert R, Heller R: Antitumor electrochemotherapy. Biomedical applications of electric pulses with special emphasis on antitumor electrochemotherapy. Bioelectrochemistry and Bioenergetics, 38: 203-207, 1995.
3. Heller R, Jaroszeski M, Messina JL, Rapaport DP, DeConti RC, Fenske NA, Gilbert R, Mir LM, Reintgen DS: Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy, Cancer, 77: 964-971, 1996.
4. Belehradek J Jr, Orlowski S, Ramirez LH, Pron J, Poddevin B, Mir LM: Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochem. Biophys. Acta, 1190: 155-163, 1994.
5. Domenge C, Orlowski S, Lubolnski B, De Baere T, Schwaab G, Belehradek J, Mir LM: Antitumor electrochemotherapy: new advances in the clinical protocol. Cancer, 77: 956-963, 1996.
6. Glass FL, Pepine ML, Fenske NA, Jarozeski M, Reintgen DS, Heller R: Bleomycin-mediated electrochemotherapy of metastatic melanoma. Arch. Dermatol., 132: 1353-1357, 1996.
7. Glass LF, Fenske NA, Jaroszeski M, Perrot R, Harvey DT, Reintgen DS, Heller R: Bleomycin-mediated electrochemotherapy of basal cell carcinoma. J. Am. Acad. Dermatol., 34: 82-86, 1996.
8. Heller R, Jaroszeski M, Perrot R, Messina J, Gilbert R: Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy, Melanoma Res., 7: 10-18, 1997.
9. Glass LF, Jaroszeski M, Gilbert R, Reintgen DS, Heller R: Intralesional bleomycin-mediated electrochemotherapy in 20 patients with basal cell carcinoma, J. Am. Acad. Dermatol., 37: 596-599, 1997.
10. Hoffman GA, Dev SB: Electroporation: from research laboratories to clinical practice, IEEE EMBS Annu. Internat. Conf., 1420-21, 1993.
11. Orlowski S, Mir LM: Cell electropermeabilisation: a new tool for biochemical and pharmacological studies, Biochem. Biophys. Acta. 1154: 51-63, 1993.
12. Weaver JC: Electroporation theory. Concepts and mechanisms. Methods in Molecular Biology, 47: 1-26, 1995.
13. Hofmann GA: Instrumentation, Methods in Molecular Biology, 47: 27-45, 1995.
14. Jaroszeski MJ, Gilbert R, Perrott R, Heller R: Enhanced effects of multiple treatment electrochemotherapy. Melanoma Res. 6: 427-433, 1996.
15. Gilbert RA, Jaroszeski MJ, Heller R: Novel electrode designs for electrochemotherapy, Biochem. Biophys. Acta. 1334: 9-14, 1996.
16. Daskalov I, Bankov S: Electrical stimulation of innervated muscles, J. Clin. Eng., 22: 383-390, 1997.
17. Neumann E, Sprafke A, Boldt E, Wolf H: Biophysical considerations of membrane electroporation, in Guide to Electroporation and Electrofusion (Chang D.C., Chassy B.M., Saunders J. A., Sowers A. E., Editors), San Diego, CA: Academic Press 1992, pp. 77-90.
18. Saulis G, Venslauskas MS: Cell electroporation. Part 1. Theoretical simulation of the process of pore formation in a cell. Bioelectrochem. and Bioenergetics, 32: 221-235, 1993.