Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas: A preliminary study in a spontaneous feline model

Cancer Chemotherapy and Pharmacology

Volumn 59, Issue 3, 2007, Pages 375-381

  Spugnini, Enrico P ^a   Baldi, Alfonso ^a   Vincenzi, Bruno ^b   Bongiorni, Franco ^c   Bellelli, Corrado ^d   Citro, Gennaro ^a   Porrello, Alessandro ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^c Ambulatorio Dr Bongiorni   (Italy)

^d Zoospedale Flamino   (Italy)

Author keywords

Adjuvant; Bleomycin; Cat; Electrochemotherapy; Sarcoma

Indexed keywords

BLEOMYCIN;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER ADJUVANT THERAPY; CANCER MODEL; CANCER RECURRENCE; CANCER SURGERY; CAT; CHRONOTHERAPY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG TOLERABILITY; ELECTRIC POTENTIAL; ELECTROCHEMOTHERAPY; FEASIBILITY STUDY; FIBROSARCOMA; INTERMETHOD COMPARISON; INTRAOPERATIVE PERIOD; METASTASIS; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECURRENT CANCER; RETREATMENT; SOFT TISSUE SARCOMA; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; BLEOMYCIN; CAT DISEASES; CATS; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DISEASE-FREE SURVIVAL; ELECTROCHEMOTHERAPY; FIBROSARCOMA; INTRAOPERATIVE CARE; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE CARE; SOFT TISSUE NEOPLASMS; SURVIVAL RATE;

EID: 33845873617     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-006-0281-y     Document Type: Article

References (20)

1. Belehradek M, Domenge C, Luboinski B, Paoletti C, Mir LM (1993) Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 72:3694-3700
2. Bujko K, Suit HD, Springfield DS, Convery K (1993) Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gynecol Ostet 176:124-134
3. Cronin K, Page RL, Spodnick G, Dodge R, Hardie EN, Price GS, Ruslander D, Thrall DE (1998) Radiation therapy and surgery for fibrosarcoma in 33 cats. Vet Radiol Ultrasound 39:51-56
4. Edmonson JH, Petersen IA, Shives TC, Mahoney MR, Rock MG, Haddock MG, Sim FH, Maples WJ, O'Connor MI, Gunderson LL, Foo ML, Pritchard DJ, Buckner JC, Stafford SL (2002) Chemotherapy, irradiation, and surgery for function-preserving therapy of primary extremity soft tissue sarcomas. Cancer 94:786-792
5. Hershy EA, Søremno KU, Hendrick MJ, Shofer FS, Vail DM (2000) Prognosis for presumed feline vaccine associated sarcoma after excision: 61 cases (1986-1996). J Am Vet Med Assoc 216:58-61
6. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
7. Martano M, Morello E, Ughetto M, Iussich S, Petterino C, CascioP, Buracco P (2005) Surgery alone versus surgery and doxorubicin for the treatment of feline injection-site sarcomas: a report of 69 cases. Vet J 170:84-90
8. Mennuni C, Calvaruso F, Zampaglione I, Rizzuto G, Rinaudo D, Dammassa E, Ciliberto G, Fattori E, La Monica N (2002) Hyaluronidase increases electrogene transfer efficiency in skeletal muscle. Hum Gene Ther 13:335-365
9. Mir LM, Devauchelle P, Quintin-Colonna F, Delisle F, Doliger S, Fredelizi D, Belehradek J Jr, Orlowski S (1997) First clinical trial of cat soft-tissue sarcomas treatment by electrochemotherapy. Br J Cancer 76:1617-1622
10. O'Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, Wunder J, Kandel R, Goddard K, Sadura A, Pater J, Zee B (2002). Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomized trial. Lancet 359:2235-2241
11. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1-39
12. Poirier VJ, Thamm DH, Kurzman ID, Jeglum KA, Chun R, Obradovich JE, O'Brien M, Rogers MF III, Phillips BS, Vail DM (2002) Liposome-encapsulated doxorubicin (Doxil) and doxorubicin in the treatment of vaccine-associated sarcoma in cats. J Vet Intern Med 16:726-731
13. Pron G, Belehradec J Jr, Mir LM (1993) Identification of a plasma membrane protein that specifically binds bleomycin. Biochem Biophys Res Commun 194:333-337
14. Sadoski C, Suit HD, Rosenberg A, Mankin H, Efird J (1993) Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissues. J Surg Oncol 52:223-230
15. Spugnini EP (2002) Use of hyaluronidase for the treatment of extravasation of chemotherapeutic agents in six dogs. J Am Vet Med Assoc 221:1437-1440
16. Spugnini EP, Porrello A (2003) Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses. J Exp Clin Cancer Res 22:571-580
17. Spugnini EP, Citro G, Porrello A (2005) Rational design of new electrodes for electrochemotherapy. J Exp Clin Cancer Res 24:245-254
18. Spugnini EP, Dragonetti E, Vincenzi B, Onori N, Citro G, Baldi A (2006). Pulse mediated chemotherapy enhances local control and survival in a spontaneous canine model of primary mucosal melanoma. Melanoma Res 16:23-27
19. Suit HD, Mankin HJ, Wood WC, Proppe KH (1985) Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer 55:2659-2667
20. Zaharoff DA, Barr RC, Li C-Y, Yuan F (2002) Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. Gene Ther 9:1286-1290