Assessment of the genotoxicity of trichloroethylene and its metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), in the comet assay in rat kidney

Mutagenesis

Volumn 23, Issue 1, 2008, Pages 27-33

  Clay, Philip ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

(1,2 DICHLOROVINYL)CYSTEINE; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS;

ANIMALS; CELLS, CULTURED; COMET ASSAY; CYSTEINE; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY TUBULES, PROXIMAL; MALE; MUTAGENS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; TRICHLOROETHYLENE;

ANIMALIA; RATTUS;

EID: 38549146556     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gem034     Document Type: Article

References (28)

1. ECETOC (1994) Trichloroethylene: Assessment of Human Carcinogenic Hazard. Technical Report No. 60. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium.
2. Goeptar, A. R., Commandeur, J. N. M., van Ommen, B., van Bladeren, P. J. and Vermeulen, N. P. E. (1995) Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway. Chem. Res. Toxicol., 8, 3-21.
3. Lock, E. A. and Reed, C. J. (2006) Trichloroethylene: mechanisms of renal toxicity and renal cancer and relevance to risk assessment. Toxicol. Sci., 91, 313-331.
4. US National Research Council (2006) Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues. The National Academies Press, Washington, DC.
5. Green, T., Dow, J., Ellis, M. K., Foster, J. R. and Odum, J. (1997) The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene. Chem. Biol. Interact., 105, 99-117.
6. Maltoni, C., Lefemine, G., Cotti, G. and Perino, G. (1988) Long term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann. N. Y. Acad. Sci., 534, 316-342.
7. NTP (1988) National Toxicology Program Report: Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies). NTP TR 273. Research Triangle Park, NC .
8. NTP (1990) National Toxicology Program Report: Carcinogenesis Studies of Trichloroethylene (without Epichlorohydrin) in F344 Rats and B6C3F1 Mice. NTP TR 243. Research Triangle Park, NC.
9. Terracini, B. and Parker, V. H. (1965) A pathological study on the toxicity of S-1,2-dichlorovinyl-L-cysteine. Food Cosmet. Toxicol., 3, 67-74.
10. Lash, L. H., Elfarra, A. A. and Anders, M. W. (1986) Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. J. Biol. Chem., 261, 5930-5935.
11. Dekant, W., Berthold, K., Vamvakas, S., Henschler, D. and Anders, M. W. (1988) Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-1- cysteine and S-(1,2,2-trichlorovinyl)-1-cysteine formed by cysteine conjugate beta-lyase. Chem. Res. Toxicol., 1, 175-178.
12. MacFarlane, M., Foster, J. R., Gibson, G. G., King, L. J. and Lock, E. A. (1989) Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity. Toxicol. Appl. Pharmacol., 98, 185-197.
13. Gandolfi, A. J., Nagle, R. B., Soltis, J. J. and Plescia, F. H. (1981) Nephrotoxicity of halogenated vinyl cysteine compounds. Res. Commun. Chem. Pathol. Pharmacol., 33, 249-261.
14. Darnerud, P. O., Brandt, I., Feil, V. J. and Bakke, J. E. (1989) Dichlorovinylcysteine (DCVC) in the mouse kidney: tissue-binding and toxicity after glutathione depletion and probenecid treatment. Arch. Toxicol., 63, 345-350.
15. Lash, L. H., Sausen, P. J., Duescher, R. J., Cooley, A. J. and Elfarra, A. A. (1994) Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-l-cysteine and S-(1,2-dichlorovinyl)-1-cysteine sulfoxide. J. Pharmacol. Exp. Ther., 269, 374-383.
16. Vaidya, V. S., Shankar, K., Lock, E. A., Bucci, T. J. and Mehendale, H. M. (2003) Renal injury and repair following S-1,2 dichlorovinyl-lcysteine administration to mice. Toxicol. Appl. Pharmacol., 188, 110-121.
17. Tice, R. R. (1995) The single cell gel/comet assay: a microgel electrophoretic technique for the detection of DNA damage and repair in individual cells. In Phillips, D. H. and Venitt, S. (eds), Environmental Mutagenesis. Bios Scientific, Oxford, pp. 315-339.
18. Fairbairn, D. W., Olive, P. L. and O'Neill, K. L. (1995) The comet assay: a comprehensive review. Mutat. Res., 339, 37-59.
19. Anderson, D., Yu, T.-W. and McGregor, D. B. (1998) Comet assay responses as indicators of carcinogen exposure. Mutagenesis, 13, 539-555.
20. Rojas, E., Lopez, M. C. and Valverde, M. (1999) Single cell gel electrophoresis assay: methodology and applications. J. Chromatogr. B Biomed. Appl., 722, 225-254.
21. Speit, G. and Hartmann, A. (1999) The comet assay (single-cell gel test)- a sensitive genotoxicity test for the detection of DNA damage and repair. In Henderson, D. S. (ed.), Methods in Molecular Biology, Vol. 113, DNA Repair Protocols: Eucaryotic Systems. Humana Press, Totowa, NJ, pp. 203-212.
22. Singh, N. P. (2000) Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat. Res., 455, 111-127.
23. Vinay, P., Gougoux, A. and Lemieux, G. (1981) Isolation of a pure suspension of rat proximal tubules. Am. J. Physiol., 241, F403-F411.
24. Hartmann, A., Agurell, E., Beevers, C. et al. (2003) Recommendations for conducting the in vivo alkaline comet assay. Mutagenesis, 18, 45-51.
25. Eyre, R. J., Stevens, D. K., Parker, J. C. and Bull, R. J. (1995) Renal activation of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice. J. Toxicol. Environ. Health, 46, 465-481.
26. Robbiano, L., Baroni, D., Carrozzino, R., Mereto, E. and Brambilla, G. (2004) DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney. Toxicology, 204, 187-195.
27. Jaffe, D. R., Hassall, C. D., Gandolfi, A. J. and Brendel, K. (1985) Production of DNA single strand breaks in rabbit renal tissue after exposure to 1,2-dichlorovinylcysteine. Toxicology, 35, 25-33.
28. Mally, A., Walker, C. L., Everitt, J. I., Dekant, W. and Vamvakas, S. (2006) Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L- cysteine in vitro. Toxicology, 224, 108-118.