Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 77-86

  Wilson, Jennifer M ^a   Henderson, Graham ^a   Black, Fiona ^a   Sutherland, Andrew ^a   Ludwig, Robert L ^b   Vousden, Karen H ^b   Robins, David J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Autoubiquitylation inhibitors; Cell cycle arrest; Deazaflavins; Heterocycle synthesis; p53

Indexed keywords

10 (2 CHLOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (2 FLUOROPHENYL) 7 (TRIFLUOROMETHYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (2 FLUOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (2 FLUOROPHENYL) 9 (TRIFLUOROMETHYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (3 CHLOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (3 FLUOROPHENYL) 7 (TRIFLUOROMETHYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (3 FLUOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (4 CHLOROPHENYL) 7 (TRIFLUOROMETHYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (4 CHLOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (4 FLUOROPHENYL) 7 (TRIFLUOROMETHYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (4 FLUOROPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 10 (4 METHYLPHENYL) 7 NITRO 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 5 DEAZAFLAVINE DERIVATIVE; 6 CHLORO 10 (2 CHLOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 (2 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 (3 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 (4 CHLOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 (4 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 (4 METHYLPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLORO 10 PHENYL 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 CHLOROURACIL; 6 FLUORO 10 (2 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 FLUORO 10 (3 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 6 FLUORO 10 (4 FLUOROPHENYL) 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 7 NITRO 10 PHENYL 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; 8 CHLORO 10 PHENYL 10H PYRIMIDO[4,5 B]QUINOLINE 2,4 DIONE; NITRO DERIVATIVE; PROTEIN INHIBITOR; PROTEIN P53; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR WEIGHT;

APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; FLAVINS; FLOW CYTOMETRY; HUMANS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROTO-ONCOGENE PROTEINS C-MDM2; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33750941024     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.011     Document Type: Article

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