Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon

Journal of Agricultural and Food Chemistry

Volumn 53, Issue 5, 2005, Pages 1823-1827

  Kobæk Larsen, Morten ^a   Christensen, Lars P ^b   Vach, Werner ^a   Ritskes Hoitinga, Jelmera ^a   Brandt, Kirsten ^c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

(3R) falcarinol; Aberrant crypt foci; BDIX rats; Colon carcinogenesis; Daucus carota; Natural toxicant

Indexed keywords

AZOXYMETHANE; PANAXYNOL; STARCH;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CANCER INHIBITION; CARROT; COLON CANCER; CONTROLLED STUDY; DIETARY INTAKE; FEEDING; MAIZE; MALE; NONHUMAN; PRECANCER; RAT;

ALKYNES; ANIMALS; AZOXYMETHANE; COLONIC NEOPLASMS; DAUCUS CAROTA; DIET; DIYNES; FATTY ALCOHOLS; MALE; PLANT EXTRACTS; PRECANCEROUS CONDITIONS; RATS;

ANIMALIA; DAUCUS CAROTA; ZEA MAYS;

EID: 14644402382     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf048519s     Document Type: Article

References (32)

1. Trichopoulou, A.; Naska, A.; Antoniou, A.; Friel, S.; Trygg, K.; Turrini, A. Vegetable and fruit: The evidence in their favour and the public health perspective. Int. J. Vitam. Nutr. Res. 2003, 73, 63-69.
2. Maynard, M.; Gunnell, D.; Emmett, P.; Frankel, S.; Smith, G. D. Fruit, vegetables, and antioxidants in childhood and risk of adult cancer: The Boyd Orr cohort. J. Epidemiol. Community Health 2003, 57, 218-225.
3. Gundgaard, J.; Nielsen, J. N.; Olsen, J.; Sørensen, J. Increased intake of fruit and vegetables: estimation of impact in terms of life expectancy and healthcare costs. Public Health Nutr. 2003, 6, 25-30.
4. Kris-Etherton, P. M.; Etherton, T. D.; Carlson, J.; Gardner, C. Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease. Curr. Opin. Lipidol. 2002, 13, 397-407.
5. Gry, J.; Kovatsis, A.; Rhodes, M.; Rosa, E.; Rosner, H.; Speijers, G.; Søborg, I.; Walker, A. Information on Inherent Food Plant Toxicants-Guide to Resources Generated by the EU-AIR-NETTOX Project; Danish Veterinary and Food Administration: Søborg, Denmark, 1998.
6. Brandt, K.; Christensen, L. P.; Hansen-Møller, J.; Hansen, S. L.; Haraldsdóttir, J.; Jespersen, L.; Purup, S.; Kharazmi, A.; Barkholt, V.; Frøkiær, H.; Kobæk-Larsen, M. Health promoting compounds in vegetables and fruits. Trends Food Sci. Technol. 2004, 15, 384-393.
7. Thomalley, P. J. Isothiocyanates: Mechanism of cancer chemopreventive action. Anti-Cancer Drugs 2002, 13, 331-338.
8. Omenn, G. S.; Goodmann, G. E.; Thornquist, M. D.; Balmes, J.; Cullen, M. R.; Glass, A.; Keogh, J. P.; Meyskens, F. L., Jr.; Valanis, B.; Williams, J. H., Jr. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. New Engl. J. Med. 1996, 334, 1150-1155.
9. Greenberg, E. R.; Baron, J. A.; Karagas, M. R.; Stukel, T. A.; Nierenberg, D. W.; Stevens, M. M.; Mandel, J. S.; Haile, R. W. Mortality associated with low plasma concentration of β-carotene and the effect of oral supplementation. J. Am. Med. Assoc. 1996, 275, 699-703.
10. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. New Engl. J. Med. 1994, 330, 1029-1035.
11. Hansen, S. L.; Purup, S.; Christensen, L. P. Bioactivity of falcarinol and the influence of processing and storage on its content in carrots (Daucus carota L.). J. Sci. Food Agric. 2003, 83, 1010-1017.
12. Bernart, M. W.; Cardellina, J. H., II; Balaschak, M. S.; Alexander, M.; Shoemaker, R. H.; Boyd, M. R. Cytotoxic falcarinol oxylipins from Dendropanax arboreus. J. Nat. Prod. 1996, 59, 748-753.
13. Saita, T.; Katano, M.; Matsunaga, H.; Yamamoto, H.; Fujito, H.; Mori, M. The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol. Chem. Pharm. Bull. 1993, 41, 549-552.
14. Matsunaga, H.; Katano, M.; Yamamoto, H.; Fujito, H.; Mori, M.; Takata, K. Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer. Chem. Pharm. Bull. 1990, 38, 3480-3482.
15. Calabrese, E. J.; Baldwin, L. A. Applications of hormesis in toxicology, risk assessment and chemotherapeutics. Trends Pharmacol. Sci. 2002, 23, 331-337.
16. Haraldsdóttir, J.; Jespersen, L.; Hansen-Møller, J.; Hansen, S. L.; Christensen, L. P.; Brandt, K. Recent developments in bioavailability of falcarinol. In Health Promoting Compounds in Vegetables and Fruit; Brandt, K., Åkesson, B., Eds; Proceedings of the workshop in Karrebæksminde, Denmark, 6-8 Nov; DIAS Report-Horticulture 29, 24-28 (http://www.agrsci.dk/ pvf/Healthpromotingcompounds3/PDF/DJFrap29Have.pdf).
17. Rieder, A.; Adamek, M.; Wrba, H. Delay of diethylnitrosamine-induced hepatoma in rats by carrot feeding. Oncology 1983, 40, 120-123.
18. Corpet, D. E.; Tache, S. Most effective colon cancer chemo-preventive agents in rats: A systematic review of aberrant crypt foci and tumor data, ranked by potency. Nutr. Cancer Int. J. 2002, 43, 1-21.
19. Kobæk-Larsen, M.; Fenger, C.; Hansen, K.; Nissen, I.; Diderichsen, A.; Thorup, I.; van Bieman, M.; Vach, W.; Ritskes-Hoitinga, J. Comparative studies of the histopathology of azoxymethane-induced colonic tumors in three inbred rat strains: BDIX/Orllco, F344/NHsd, and WAG/RijNsd. Comp. Med. 2002, 52, 50-57.
20. Czepa, A.; Hofmann, T. Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree. J. Agric. Food Chem. 2003, 51, 3865-3873.
21. Nakano, Y.; Matsunaga, H.; Saita, T.; Mori, M.; Katano, M.; Okabe, H. Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. Biol. Pharm. Bull. 1998, 21, 257-261.
22. Hirakura, K.; Morita, M.; Nakajima, K.; Ikeya, Y.; Mitsuhashi, H. Three acetylenic compounds from roots of Panax ginseng. Phytochemistry 1992, 31, 899-903.
23. 17 Polyacetylenic alcohols as the major constituents in roots of Petroselinum crispum Mill. ssp. tuberosum. J. Agric. Food Chem. 1990, 38, 1445-1447.
24. Zheng, G.; Lu, W.; Aisa, H. A.; Cai, J. Absolute configuration of falcarinol, a potent antitumor agent commonly occurring in plants. Tetrahedron Lett. 1999, 40, 2181-2182.
25. Terada, A.; Tanoue, Y.; Kishimoto, D. (-)-(9Z)-1,9 -Heptadecadiene-4,6- diyn-3-ol as a principal component of the resinous sap of Evodiopanax innovans Nakai, Japanese name, Takanotsume, and its role in an ancient golden varnish of Japan. Bull. Chem. Soc. Jpn. 1989, 62, 2977-2980.
26. Bohlmann, F.; Burkhardt, T.; Zdero, C. Naturally Occurring Acetylenes; Academic Press: London, 1973; pp 464-485.
27. Kuo, Y.-C.; Lin, Y. L.; Huang, C.-P.; Shu, J.-W.; Tsai, W.-J. A tumor cell growth inhibitor from Saposhnikovae divaricata. Cancer Invest. 2002, 20, 955-964.
28. Cunsolo, F.; Ruberto, G. Bioactive metabolites from Sicilian marine fennel, Crithmum maritimum. J. Nat. Prod. 1993, 56, 1598-1600.
29. Miyazawa, M.; Shimamura, H.; Bhuva, R. C.; Nakamura, S.; Kameoka, H. Antimutagenic activity of falcarindiol from Peucedanum praeruptorum. J. Agric. Food Chem. 1996, 44, 3444-3448.
30. Hansen, L.; Hammershøy, O.; Boll, P. M. Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola. Contact Dermatitis 1986, 14, 91-93.
31. DeWille, J. W.; Waddell, K.; Steinmeyer, C.; Farmer, S. J. Dietary fat promotes mammary tumorigenesis in MMTV/ v-Ha-ras transgenic mice. Cancer Lett. 1993, 69, 59-66.
32. Wang, Y.; Cummings, S. L.; Gietzen, D. W. Temporal-spatial pattern of c-Fos expression in the rat brain in response to indispensable amino acid deficiency II. The learned taste aversion. Mol. Brain Res. 1996, 40, 35-41.