Inhibitory effect of panaxynol on the proliferation of rat aortic smooth muscle cell and its mechanisms

Chinese Pharmacological Bulletin

Volumn 21, Issue 11, 2005, Pages 1313-1319

  Jiang, Li Ping ^a,b   Nie, Bao Ming ^a   Lu, Hui Min ^b   Gan, Li Jun ^b   Chen, Hong Zhuan ^a   Lu, Yang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b JIANGXI MEDICAL COLLEGE   (China)

Author keywords

Intracelluar free Ca2+ concentration; mtTF1; Panaxynol; PDGF BB; Proliferation; Rat aortic smooth muscle cells

Indexed keywords

CALCIUM ION; DNA; FURA 2 ACETOXYMETHYL ESTER; FURA 3 ACETOXYMETHYL ESTER; MESSENGER RNA; MITOCHONDRIAL TRANSCRIPTION FACTOR 1; PANAXYNOL; PLATELET DERIVED GROWTH FACTOR BB; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CALCIUM CELL LEVEL; CELL COUNT; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 32344433485     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Glass CK, Witztum JL. Atherosclerosis, the road ahead[J]. Cell, 2001, 104(4):503-16.
2. Boehm M, Nabel EG. The cell cycle and cardiovascular diseases [J]. Prog Cell Cycle Res, 2003, 5:19-30.
3. Yoshida T, Azuma H, Aihara K et al. Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat artery [J]. Atherosclerosis, 2005, 178(1):39-47
4. Yoshioka S, Okimura Y, Takahashi Y et al. Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC [J]. Life Sciences, 2004, 74:2097-109.
5. Takai S, Jin D, Kirimura K et al. Effects of a liproxygenase inhibitor, panaxynol, on vascular contraction induced by angiotention [J]. Jpn Pharmacol, 1999, 80(1):89-92.
6. Kuo SC, Teng CM, Lee JC et al. Antiplatelet components in Panax ginseng[J]. Planta Med, 1990, 56(2):164-7.
7. Kwon BW, Nam JY, Lee SH et al. Isolation of cholesteryl ester transfer protein inhibitors from Panaxginseng roots[J]. Chem Parm Bull, 1996, 44(2):444-5.
8. Kwon BW, Ro Sh, Kim MK et al. Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit acyl-CoA: cholesterol acyltransferase[J]. Planta Med, 1997, 63:552-3.
9. Zhang YH, Fang LH, Ku BS. Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression[J]. Biochemical Pharmacology, 2003, 66(9):1853-60.
10. 2+ concentration dynamics in vascular smooth muscle cells of rat mesenteric arteries[J]. Cell Calcium, 2002, 32(3):105-20.
11. Lene H, Per MB. Polyacetylenes in Araliaceae: their chemistry, biosynthesis and biological significance[J]. Phytochemistry, 1986, 25(2):285-93.
12. Bird SD, Hasan Q, Davis PF et al. Platelet derived growth factor-BB induced calcium transients in cultured human peritoneal mesothelial cells[J]. ASAIO J, 1998, 44(6):835-40.
13. Hollenbeck ST, Nelson PR, Yamamura S et al. Intracellular calcium transients are necessary forplatelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration[J]. J Vasc Surg, 2004, 40(2):351-8.
14. Fisher RP, Clayton DA. Purification and characterization of human mitochondrial transcription factor 1[J]. Mol Cell Biol, 1988, 8(8):3496-509.