Some biochemical and haematological effects of black seed (Nigella sativa) oil on Trypanosoma brucei-infected rats

African Journal of Biotechnology

Volumn 7, Issue 2, 2008, Pages 153-157

  Ekanem, Justine T ^a   Yusuf, Oluwatosin K ^a  

^a UNIVERSITY OF ILORIN   (Nigeria)

Author keywords

Black seed oil; Management; Sleeping sickness; Trypanosoma brucei

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; HEMOGLOBIN; NIGELLA SATIVA EXTRACT;

AFRICAN TRYPANOSOMIASIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMISTRY; BLACK CUMIN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ERYTHROCYTE COUNT; HEMATOCRIT; HEMATOLOGY; HEMOGLOBIN DETERMINATION; IMMUNOREGULATION; LEUKOCYTE COUNT; LIFESPAN; NONHUMAN; PARASITEMIA; RAT; THROMBOCYTE COUNT; TRYPANOSOMA BRUCEI;

NIGELLA SATIVA; RATTUS; TRYPANOSOMA BRUCEI;

EID: 38549090553     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Abuharfeil N, AlOran R, Aboshehada M (1999). The effect of bee honey on the proliferative activity of humab B- and T- lymphocytes and the activity of phagocytes. Food Agric. Immunol. 11: 169-177.
2. Adamu SO, Johnson TL (1997) Statistics for beginners, Book 1. SAAL Publications, Ibadan, Nigeria. pp. 184-199.
3. Ali BH, Blunden G (2003). Pharmacological and toxicological properties of Nigella sativa. Phytother. Res. 17(4): 299-305.
4. Anosa VO (1988). Haematological and biochemical changes in human and animal trypanosomiasis. Rev. Elev. Med. Vet. Pays Trop 41(42): 151-164.
5. Biryomumaisho S, Katunguka-Rwakishaya E (2007). The pathogenesis of anaemia in goats experimentally infected with Trypanosoma congolense or Trypanosoma brucei: Use of the myeloid:erythroid ratio. Vet. Parasitol. 143: 354-357.
6. Boutignon F, Huet G, Demeyer D, Richet C, Degand P (1990). Study of proteolytic activities released by incubation of trypanosomes (Trypanosoma brucei brucei). Biochim. Biophys. Acta 1035: 369-377.
7. Chibale K (2005). Economic drug discovery and rational medicinal chemistry for tropical diseases. Pure Appl. Chem. 77: 1957-1964.
8. Chretien JPL, Smoak BL (2005). African Trypanosomiasis: Changing epidemiology and consequences. Curr. Infect. Dis. Rep. 7: 54-60.
9. th edn. Churchill Livingston. Edingburgh
10. Davis CE (1982). Thrombocytopenia: a uniform complication of African trypanosomiasis. Acta Trop. 39: 123 -133.
11. Ekanem JT (1989). Extracellular fractions derived from Trypanosoma brucei activate erythrocyte Ca2+- ATPase. Med. Sci. Res. 17: 739-740.
12. Ekanem JT, Akanji MA, Odutuga AA (1994). Host and parasite derived factors during mammalian African trypanosomiasis. Biokemistri 4: 103-116.
13. Ekanem JT, Akanji MA, Odutuga AA (1996). Extracellular proteins of Trypanosoma brucei origin lyse erythrocytes of rats in vitro. Biokemstri. 6: 21-29.
14. Ekanem JT, Majolagbe OR, Sulaiman FA, Muhammad NO (2006). Effects of honey-supplemented diet on the parasitemia and some enzymes of Trypanosoma brucei-infected rats. Afr. J. Biotech. 5: 1557-1561
15. Ekanem JT, Yusuf OK (2005). Activities of alkaline phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in liver and serum of Trypanosoma brucei-infected rats treated with honey. Biokemistri 17: 185-191.
16. Gornall AG, Bardawill CJ, David MM (1949). Determination of Serum protein by means of the biuret reaction. J. Biol. Chem. 177: 751-756.
17. Hajhashemi V, Ghannadi A, Jafarabadi H (2004). Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother. Res. 18(3): 195-199.
18. Haq A, Lobo PI, Al-Tufail M, Rama NR, Al-Sedairy ST (1999). Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int. J. Immunopharmacol. 21(4): 283-295.
19. Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J (2004). Natural products active against African trypanosomes: a step towards new drugs. Nat. Prod. Rep. 21: 353-364.
20. Jannin J, Cattand P (2004). Treatment and control of human African trypanosomiasis. Curr.Opin. Infect. Dis. 17: 565-571.
21. Khattab MM, Nagi MN (2007). Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother. Res. (Articles online in advance of print) Published online: 18 Jan 2007. DOI: 10.1002/ptr.2083.
22. Kioy D, Mattock N (2005). Control of sleeping sickness - time to integrate approaches. Lancet 366(9487): 695-696.
23. Kökdil G, Tamer L, Ercan B, Çelik M, Atik U (2006). Effects of Nigella orientalis and N. segetalis fixed oils on blood biochemistry in rats. Phytother. Res. 20(1): 71-75.
24. Moore AC (2005). Prospects for improving African trypanosomiasis chemotherapy. J. Infect. Dis. 191: 1793-1795.
25. Nwagwu M, Okenu DMN, Olusi TA, Molokwu RI (1987). Trypanosoma brucei releases proteases extracellularly. Trans. Roy. Soc. Trop. Med. Hyg. 82: 577.
26. Pentreath VW, Kennedy GE (2004). Pathogenesis of human African trypanosomiasis. In The Trypanosomiasis (eds. I. Maudlin, P. H. Holmes and Miles) CABI Publishing, pp. 283-301.
27. Pink R, Hudson A, Mouries M-A, Bendig M (2005). Opportunities and challenges in antiparasitic drug discovery. Nat. Rev. Drug Discov. 49: 727-740.
28. nd ed.) McGraw-HILL, London, pp. 144-145.
29. Poltera AA (1985). Pathology of human African trypanosomiasis with reference to experimental African trypanosomiasis and infections of the central nervous system. Br. Med. Bull. 41: 169-174.
30. Salem ML (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol. 5(13-14): 1749-1770.
31. Sternberg JM (2004). Human African trypanosomiasis: clinical presentation and immune response. Parasite Immunol. 26: 469-476
32. Student Pseudo, Gosset WS (1908). The error of a mean. Biometrika 6: 1-25.
33. Suliman HB, Feldman BF (1989). Pathogenesis and aetiology of anaemia in trypanosomiasis with special reference to T. brucei and T. evansi. Protozool. Abtr. 13: 37-45.
34. Tekeoglu I, Dogan A, Demiralp L (2006). Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother. Res. 20(10): 869-871.