Loss of p73 expression in six non-small cell lung cancer cell lines is associated with 5′CpG island methylation

Experimental and Molecular Pathology

Volumn 84, Issue 1, 2008, Pages 59-63

  Liu, Kaishan ^a   Zhan, Meiyi ^a   Zheng, Peie ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

Methylation; Non small cell lung cancer; p73 gene

Indexed keywords

PROTEIN P73;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CHROMOSOME 1P; CONTROLLED STUDY; CPG ISLAND; DNA POLYMORPHISM; EXON; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; METHYLATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 38549088094     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2007.10.002     Document Type: Article

References (23)

1. Belinsky S.A. Gene promoter hypermethylation as a biomarker in lung cancer. Nat. Rev., Cancer 4 (2004) 707-717
2. Belinsky S.A. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 26 (2005) 1481-1487
3. Chen C.L., Ip S.M., Cheng D., Wong L.C., and Ngan H. P73 gene expression in ovarian cancer tissues and cell lines. Clin. Cancer Res. 6 (2000) 3910-3915
4. Chi S.G., Chang S.G., Lee S.J., Lee C.H., Kim J., and Park J.H. Elevated and biallelic expression of p73 is associated with progression of human bladder cancer. Cancer Res. 59 (1999) 2791-2793
5. Chu L.C., Eberhart C.G., Grossman S.A., and Herman J.G. Epigenetic silencing of multiple genes in primary CNS lymphoma. Int. J. Cancer 119 (2006) 2487-2491
6. Corn P.G., Kuerbitz S.J., van Noesel M.M., Esteller M., Compitello N., Baylin S.B., and Herman J.G. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′CpG island methylation. Cancer Res. 59 (1999) 3352-3356
7. Han S., Sermba S., Abe T., Makino N., Furukawa T., Fukushige S., Takahashi H., Sakurada A., Sato M., Shiiba K., Matsuno S., Nimura Y., Nakagawara A., and Horii A. Infrequent somatic mutations of the p73 gene in various human cancers. Eur. J. Surg. Oncol. 25 (1999) 194-198
8. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., and Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 9821-9826
9. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J.C., Valent A., Minty A., Chalon P., Lelias J.M., Dumont X., Ferrara P., McKeon F., and Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90 (1997) 809-819
10. Kang M.J., Park B.J., Byun D.S., Park J.I., Kim H.J., Park J.H., and Chi S.G. Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma. Clin. Cancer Res. 6 (2000) 1767-1771
11. Kovalev S., Marchenko N., Swendeman S., LaQuaglia M., and Moll U.M. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ. 9 (1998) 897-903
12. Mai M., Qian C., Yokomizo A., Tindall D.J., Bostwick D., Polychronakos C., Smith D.I., and Liu W. Loss of imprinting and allele switching of p73 in renal cell carcinoma. Oncogene 17 (1998) 1739-1741
13. Mai M., Yokomizo A., Qian C., Yang P., Tindall D.J., Smith D.I., and Liu W. Activation of p73 silent allele in lung cancer. Cancer Res. 58 (1998) 2347-2349
14. Martinez-Delgado B., Melendez B., Cuadros M., Garcia M.J., Nomdedeu J., Rivas C., Fernandez-Piqueras J., and Benitez J. Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas. Int. J. Cancer 102 (2002) 15-19
15. Melino G., De Laurenzi V., and Vousden K.H. P73: friend or foe in tumorigenesis. Nat. Rev., Cancer 2 (2002) 605-615
16. Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., Baylin S.B., and Sidransky D. 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1 (1995) 633-634
17. Nomoto S., Haruki N., Kondo M., Konishi H., and Takahashi T. Search of mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res. 58 (1998) 1380-1383
18. Peters U.R., Tschan M.P., Kreuzer K.A., Baskaynak G., Lass U., Tobler A., Fey M.F., and Schmidt C.A. Distinct expression patterns of the p53-homologue p73 in malignant and normal hematopoiesis assessed by a novel real-time reverse transcription-polymerase chain reaction assay and protein analysis. Cancer Res. 59 (1999) 4233-4236
19. Sunahara M., Ichimiya S., Nimura Y., Takada N., Sakiyama S., Sato Y., Todo S., Adachi W., Amano J., and Nakagawara A. Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. Int. J. Oncol. 13 (1998) 319-323
20. Takahashi H., Ichimiya S., Nimura Y., Watanabe M., Furusato M., Wakui S., Yatani R., Aizawa S., and Nakagawara A. Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res. 58 (1998) 2076-2077
21. Yokomizo A., Mai M., Tindall D.J., Cheng L., Bostwick D.G., Naito S., Smith D.I., and Liu W. Overexpression of the wild type p73 gene in human bladder cancer. Oncogene 18 (1999) 1629-1633
22. Yoshikawa H., Nagashima M., Khan M.A., McMenamin M.G., Hagiwara K., and Harris C.C. Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene 18 (1999) 3415-3421
23. Zhu J., Jiang J., Zhou W., and Chen X. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 58 (1998) 5061-5065