Cytokines, pregnancy, and bacterial vaginosis: Comparison of levels of cervical cytokines in pregnant and nonpregnant women with bacterial vaginosis

Journal of Infectious Diseases

Volumn 196, Issue 9, 2007, Pages 1355-1360

  Beigi, Richard H ^a   Yudin, Mark H ^c   Cosentino, Lisa ^b   Meyn, Leslie A ^a,b   Hillier, Sharon L ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; CYTOKINE; INTERLEUKIN 1;

ADULT; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; DEMOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GARDNERELLA VAGINALIS; GRAM NEGATIVE ANAEROBIC BACTERIA; GRAM POSITIVE COCCI; HUMAN; MAJOR CLINICAL STUDY; MICROBIOLOGICAL EXAMINATION; MYCOPLASMA HOMINIS; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; VAGINITIS; COMPARATIVE STUDY; METABOLISM; PREGNANCY COMPLICATION; UTERINE CERVIX;

ADULT; CERVIX UTERI; CYTOKINES; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; VAGINOSIS, BACTERIAL;

EID: 38449122316     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/521628     Document Type: Article

References (29)

1. Curfs AJ, Meis GM, Hoogkamp-Korstanje AA. A primer on cytokines: sources, receptors, effects, and inducers. Clin Microbiol Rev 1997; 10:742-80.
2. Westrom L, Joesoef MJ, Reynolds G, Hagdu A, Thompson SE. Pelvic inflammatory disease and fertility: a cohort study of 1844 women with laparoscopically verified disease and control women with normal laparoscopic results. Sex Transm Dis 1992; 19:185-92.
3. Wiesenfeld HC, Hillier SL, Krohn MA, et al. Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet Gynecol 2002; 100:456-63.
4. Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low birth weight infant. N Engl J Med 1995; 333:1737-42.
5. Wennerholm U, Holm B, Mattsby-Baltzer I, et al. Interleukin-1a, interleukin-6 and interleukin-8 in cervico/vaginal secretions for screening of preterm birth in twin gestation. Acta Obstet Gynecol Scand 1998; 77:508-14.
6. Kutteh WH, Franklin RD. Quantification of immunoglobulins and cytokines in human cervical mucus during each trimester of pregnancy. Am J Obstet Gynecol 2001; 184:865-74.
7. Donders GG, Vereecken A, Bosmans E, Spitz B. Vaginal cytokines in normal pregnancy. Am J Obstet Gynecol 2003; 189:1433-8.
8. Franklin RD, Kutteh WH. Characterization of immunoglobulins and cytokines in human cervical mucus: influence of exogenous and endogenous hormones. J Reprod Immunol 1999; 42:93-106.
9. Simhan HN, Caritis SN, Krohn MA, et al. Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy. Am J Obstet Gynecol 2003; 189:560-7.
10. Yudin MH, Landers DV, Meyn LA, Hillier SL. Clinical and cervical cytokine response to treatment with oral or vaginal metronidazole for bacterial vaginosis during pregnancy: a randomized trial. Obstet Gynecol 2003; 102:527-34.
11. Genc MR, Onderdonk AB, Vardhana S, et al. Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth. Am J Obstet Gynecol 2004; 191:1324-30.
12. Genc MR, Witkin SS, Delaney ML, et al. A disproportionate increase in IL-1β over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth. Am J Obstet Gynecol 2004; 190:1191-7.
13. Genc MR, Vardhana S, Delaney ML, et al. Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women. Eur J Obstet Gynecol Reprod Biol 2004; 116:152-6.
14. Hillier SL, Martius J, Krohn MA, Kiviat N, Holmes KK, Eschenbach DA . A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med 1988; 319:972-8.
15. Watts DH, Krohn MA, Hillier SJ, Eschenbach DA. Bacterial vaginosis as a risk factor for post-cesarean endometritis. Obstet Gynecol 1990; 75:52-8.
16. Hillier SL, Kiviat NB, Hawes SE, et al. Role of bacterial vaginosis-associated microorganisms in endometritis. Am J Obstet Gynecol 1996; 175:435-41.
17. Soper DE, Bump RC, Hurt WG. Bacterial vaginosis and trichomoniasis vaginitis are risk factors for cuff cellulitis after abdominal hysterectomy. Am J Obstet Gynecol 1990; 163:1016-21.
18. Platz-Christensen JJ, Mattsby-Baltzer I, Thomsen P, Wiqvist N. Endotoxin and interleukin-ia in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis. Am J Obstet Gynecol 1993; 169:1161-6.
19. Mattsby-Baltzer I, Platz-Christensen JJ, Hosseini N, Rosen P. IL-113, IL-6, TNFa, fetal fibronectin and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis. Acta Obstet Gynecol Scand 1998; 77:701-6.
20. Beigi RH, Austin MN, Meyn LA, MA Krohn, Hillier SL. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004; 191:1124-9.
21. Amsel R, Totten PA, Spiegel CA, Chen KCS, Eschenbach DA, Holmes KK. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiological associations. Am J Med 1983; 74:14-22.
22. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
23. 2-producing Lactobacilli, and bacterial vaginosis in pregnant women. Clin Infect Dis 1993; 16(Suppl 4):S273-81.
24. Weinberg ED. Pregnancy-associated depression of cell-mediated immunity. Rev Infect Dis 1984; 6:814-31.
25. Sheffield JS, Andrews WW, Klebanoff MA, et al. Spontaneous resolution of asymptomatic chlamydia trachomatis in pregnancy. Obstet Gynecol 2005; 105:557-62.
26. Klebanoff MA, Hauth JC, MacPherson CA, et al. Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. Am J Obstet Gynecol 2004; 190(2):363-70.
27. Spandorfer SD, Neuer A, Giraldo PC, et al. Relationship of abnormal vaginal flora, proinflammatory cytokines and idiopathic infertility in women undergoing IVF. J Reprod Med 2001; 46:806-10.
28. Simhan HN, Caritis SN, Hillier SL, Krohn MA. Cervical anti-inflammatory cytokine concentrations among first-trimester pregnant smokers. Am J Obstet Gynecol 2005; 193:1999-2003.
29. Scott ME, Ma Y, Farhat S, Shiboski S, Moscicki AB. Covariates of cervical cytokine mRNA expression by real-time PCR in adolescents and young women: Effects of Chlamydia trachomatis infection, hormonal contraception, and smoking. J Clin Immunol 2006; 26:222-32.