Characterization of immunoglobulins and cytokines in human cervical mucus: Influence of exogenous and endogenous hormones

Journal of Reproductive Immunology

Volumn 42, Issue 2, 1999, Pages 93-106

  Franklin, R D ^a   Kutteh, W H ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Cervical mucus; Cytokines; Immunoglobulins; Oral contraceptives; Reproductive tract immunology; Vaginal immunology

Indexed keywords

CYTOKINE; ESTRADIOL; ETHINYLESTRADIOL PLUS NORETHISTERONE; IMMUNOGLOBULIN; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NORETHISTERONE; ORAL CONTRACEPTIVE AGENT;

ADULT; ARTICLE; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMALE GENITAL SYSTEM; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; MENSTRUAL CYCLE; MUCOSAL IMMUNITY; NORMAL HUMAN; OVULATION; PRIORITY JOURNAL; UTERINE CERVIX MUCUS;

ADULT; CERVIX MUCUS; CONTRACEPTIVES, ORAL, COMBINED; CONTRACEPTIVES, ORAL, SYNTHETIC; CYTOKINES; ETHINYL ESTRADIOL; FEMALE; HORMONES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-6; NORETHINDRONE; VAGINA;

EID: 0033024523     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0378(98)00086-2     Document Type: Article

References (26)

1. Brandtzaeg P. The role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand. J. Immunol. 22:1985;111-146.
2. Brandtzaeg P. Mucosal immunity in the female genital tract. J. Reprod. Immunol. 36:1997;23-50.
3. Cohen, P.E., Pollard, J.W., 1996. Cytokines and growth factors in reproduction. In: Bronson, R.A., Alexander, N.J., Anderson, D., Branch, D.W., Kutteh, W.H. (Eds.), Reproductive Immunology. Blackwell, Cambridge, MA, pp. 52-102.
4. Conley M.E., Delacroix D.L. Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense? Ann. Intern. Med. 106:1987;892-899.
5. Dibbelt L., Knuppen R., Jutting G., Heilmann S., Klipping C.O., Parikka-Olexik H. Group comparison of serum ethinyl estradiol, SHBG and CBG levels in 83 women using two low dose combination oral contraceptives for three months. Contraception. 43:1991;1-21.
6. Edwards R.P., Krasnow J., Kulhauy L., Wolfe K., Gooding B., Crowley-Norwick P.A. Immunoglobulin and interleukin-6 (IL-6) concentrations in cervical mucus are suppressed at ovulation. J. Soc. Gynecol. Invest. 2:1995;238.
7. Finkelman F.D., Holmes J., Katona I.M.et al. Lymphokine control of in vivo immunoglobulin isotype selection. Ann. Rev. Immunol. 8:1990;303-333.
8. Goldzieher J.W. Pharmacology of contraceptive steroids: a brief review. Am. J. Obstet. Gynecol. 160:1989;1260-1264.
9. Goldzieher J.W., Brody S.A. Pharmacokinetics of ethinyl estradiol and mestranol. Am. J. Obstet. Gynecol. 163:1990;2114-2119.
10. Hammond, K.R., Blackwell, R.E., Boots, L.R., Steinkampf, M.P., 1992. Preovulatory cervical mucus collection: evaluation of timing and techniques. 48th Annu. Meet. of the American Fertility Society, New Orleans, LA, 2-5 November 1992.
11. Jung-Hoffman C., Kuhl H. Pharmacokinetics and pharmacodynamics of oral contraceptives steroids: factors influencing steroid metabolism. Am. J. Obstet. Gynecol. 163:1990;2183-2197.
12. Kaushic C., Frauendorf E., Rossoll R.M., Richardson J.M., Wira C.R. Influence of the estrous cycle on the presence and distribution on immune cells in the rat reproductive tract. Am. J. Reprod. Immunol. 39:1998;209-216.
13. Kutteh W.H., Mestecky J. Secretory immunity in the female reproductive tract. Am. J. Reprod. Immunol. 31:1994;40-46.
14. Kutteh W.H., Hatch K.D., Blackwell R.E., Mestecky J. Secretory immune system of the female reproductive tract. I. Immunoglobulin and secretory component-containing cells. Obstet. Gynecol. 71:1988;56-60.
15. Kutteh W.H., Prince S.J., Hammond K.R., Kutteh C.C., Mestecky J. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin. Exp. Immunol. 104:1996;538-542.
16. Kutteh W.H., Moldoveanu Z., Mestecky J. Mucosal immunity in the female reproductive tract: correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation. Aids Res. Hum. Retrovir. 14:1998;S51-S55.
17. McGhee J.R., Mestecky J., Elson C.O., Kiyono H. Regulation of IgA synthesis and immune response by T cells and interleukins. J. Clin. Immunol. 9:1989;175-199.
18. Menge A.C., Mestecky J. Surface expression of secretory component and HLA class II DR antigen on glandular epithelial cells from human endometrium and two endometrial adenocarcinoma cell lines. J. Clin. Immunol. 13:1993;259-264.
19. Mestecky J., McGhee J.R. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40:1987;153-245.
20. Prabhala R.H., Wira C.R. Cytokine regulation of the mucosal immune system: in vivo stimulation by interferon-γ of secretory component and Immunoglobulin A in uterine secretions and proliferation of lymphocytes from spleen. Endocrinology. 129:1991;2915-2923.
21. Prabhala R.H., Wira C.R. Sex hormone and IL-6 regulation of antigen presentation in the female reproductive tract mucosal tissues. J. Immunol. 155:1995;5566-5573.
22. Quesnel A., Cu-Uvin S., Murphy D., Ashley R.L., Flanigan T., Neutra M.R. Comparative analysis of methods for collection and measurement of immunoglobulins in cervical and vaginal secretions of women. J. Immunol. Methods. 202:1997;153-161.
23. Schumacher, G.F.B., 1973. Soluable proteins in cervical mucus. In: Blantau, R., Moghissi, K. (Eds.), The Biology of the Cervix. University of Chicago Press, Chicago, IL, pp. 201-221.
24. Vandermolen P.T., Gu Y. Human endometrial interleukin-6 (IL-6): in vivo messenger ribonucleic acid expression, in vitro protein production, and stimulation thereof by IL-1β Fertil. Steril. 66:1996;741-747.
25. Wira C.R., Rossoll R.M. Antigen presenting cells in the female reproductive tract: influence of sex hormones on antigen presentation in the vagina. Immunology. 84:1995;505-508.
26. Wira C.R., Sandoe C.P. Specific IgA and IgG antibodies in the secretion of the female reproductive tract: effects of immunization and estradiol on expression of this response in vivo. J. Immunol. 138:1987;4159-4164.