Inter-individual variability in propofol pharmacokinetics in preterm and term neonates

British Journal of Anaesthesia

Volumn 99, Issue 6, 2007, Pages 864-870

  Allegaert, K ^a   Peeters, M Y ^b   Verbesselt, R ^a   Tibboel, D ^b   Naulaers, G ^a   De Hoon, J N ^a   Knibbe, C A ^c,d  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Anaesthetics i.v., propofol; Neonates; Pharmacology; Sedation

Indexed keywords

PROPOFOL; CREATININE; INTRAVENOUS ANESTHETIC AGENT;

ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ACCUMULATION; DRUG CLEARANCE; FEMALE; HUMAN; MALE; NEWBORN; PREMATURITY; PRIORITY JOURNAL; AGING; BIOLOGICAL MODEL; BLOOD; BODY WEIGHT; DRUG ADMINISTRATION; GESTATIONAL AGE; METABOLIC CLEARANCE RATE; PHYSIOLOGY;

AGING; ANESTHETICS, INTRAVENOUS; BODY WEIGHT; CREATININE; DRUG ADMINISTRATION SCHEDULE; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; PROPOFOL;

EID: 38449118819     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aem294     Document Type: Article

References (22)

1. Rigby-Jones AE, Nolan JA, Priston MJ, et al. Pharmacokinetics of propofol infusions in critically ill neonates, infants and children in an intensive care unit. Anesthesiology 2002; 97: 1393-400
2. Shangguan WN, Lian Q, Aarons L, et al. Pharmacokinetics of single bolus of propofol in Chinese children of different ages. Anesthesiology 2006; 104: 27-32
3. Jones RD, Chan K, Andrew LJ. Pharmacokinetics of propofol in children. Br J Anaesth 1990; 65: 661-7
4. Prins S, Peeters MY, Houmes RJ, et al. Propofol 6 % as sedative in children under 2 years of age following major craniofacial surgery. Br J Anaesth 2005; 94: 630-5
5. Allegaert K, Debeer A, Rayyan M, Devlieger H, Naulaers G. Propofol pharmacokinetics in neonates. Crit Care 2007; 11: S170
6. Raoof AA, van Obbergh LJ, Verbeeck RK. Propofol pharmacokinetics in children with biliary atresia. Br J Anaesth 1995; 74: 46-9
7. Murat I, Billard V, Vernois J, et al. Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches. Anesthesiology 1996; 84: 526-32
8. Saint-Maurice C, Cockshott ID, Douglas EJ, et al. Pharmacokinetics of propofol in young children after a single dose. Br J Anaesth 1989; 63: 667-70
9. Ghanta S, Abdel-Latif ME, Lui K, Ravindranathan H, Awad J, Oei J. Propofol compared with the morphine, atropine, and suxamethonium regimen as induction agents for neonatal endotracheal intubation: a randomized, controlled trial. Pediatrics 2007; 119: e1248-55
10. Rigby-Jones A, Priston M, Wolf A, Sneyd J. Paediatric propopol pharmacokinetics: a multicentre study. Paediatr Anaesth 2007; 17: 610
11. Favetta P, Degoute CS, Perdrix JP, et al. Propofol metabolites in man following propofol induction and maintenance. Br J Anaesth 2002; 88: 653-8
12. Guitton J, Buronfosse T, Desage M, et al. Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth 1998; 80: 788-95
13. Kearns GL, Abdel-Rahman SM, Alander SW, et al. Developmental pharmacology - drug disposition, action, and therapy in infants and children. N Engl J Med 2003; 349: 1157-67
14. Rakhmanina NY, van den Anker JN. Pharmacological research in pediatrics: from neonates to adolescents. Adv Drug Deliv Rev 2006; 58: 4-14
15. Allegaert K, Tibboel D, Naulaers G, et al. Systematic evaluation of pain in neonates: effect on the number of intravenous analgesics prescribed. Eur J Clin Pharmacol 2003; 59: 87-90
16. Allegaert K, Naulaers G, Debeer A, et al. The use of methohexital during chest tube removal in neonates. Paediatr Anaesth 2004; 14: 308-12
17. Bouwmeester NJ, Anderson BJ, Tibboel D, et al. Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children. Br J Anaesth 2004; 92: 208-17
18. Choonara IA, McKay P, Hain R, Rane A. Morphine metabolism in children. Br J Clin Pharmacol 1989; 28: 599-604
19. Allegaert K, de Hoon J, Verbesselt R, Vanhole C, Devlieger H, Tibboel D. Intra- and inter-individual variability of glucuronidation of paracetamol during repeated administration in neonates. Acta Paediatr 2005; 94: 1273-9
20. Knibbe CA, Zuideveld KP, Aarts LP, et al. Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. Br J Clin Pharmacol 2005; 59: 705-11
21. Parke TJ, Stevens JE, Rice AS, et al. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. Br Med J 1992; 305: 613-6
22. Wolf AR, Potter F. Propofol infusion in children: when does an anesthetic tool become an intensive care liability? Paediatr Anaesth 2004; 14: 435-8