Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 11, 2007, Pages 5091-5100

  Jha, Purushottam ^a   Matta, Bharati ^a   Lyzogubov, Valeriy ^a   Tytarenko, Ruslana ^a   Bora, Puran S ^a   Bora, Nalini S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CASPASE 3; CD11B ANTIGEN; CYTOCHROME C; MELANIN ASSOCIATED ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; CASPASE 8; CASPASE 9; GLYCOPROTEIN P 15095;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOPLASM; EYE EXAMINATION; FLOW CYTOMETRY; INFLAMMATORY CELL; IRIDOCYCLITIS; LEWIS RAT; MACROPHAGE; MALE; MICROSCOPY; NICK END LABELING; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; DISEASE MODEL; GERMFREE ANIMAL; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD11C; APOPTOSIS; AUTOIMMUNE DISEASES; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CASPASE 9; CD4-POSITIVE T-LYMPHOCYTES; CYTOCHROMES C; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; IN SITU NICK-END LABELING; MACROPHAGES; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIFIC PATHOGEN-FREE ORGANISMS; UVEITIS, ANTERIOR;

EID: 38449118594     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0651     Document Type: Article

References (36)

1. Bloch-Michel E, Nussenblatt RB. International uveitis study group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol. 1987;103:234-235.
2. Nussenblatt RB, Whitcup SM, Palestine AG. Uveitis: Fundamentals and Clinical Practice. 2nd ed. St. Louis: Mosby; 1996.
3. Bora NS, Woon MD, Tandhasetti MT, Cirrito TP, Kaplan HJ. Induction of experimental autoimmune anterior uveitis by a self-antigen: melanin complex without adjuvant. Invest Ophthalmol Vis Sci. 1997;38:2171-2175.
4. Bora NS, Sohn JH, Kang SG, et al. Type I collagen is the autoantigen in experimental autoimmune anterior uveitis. J Immunol. 2004;172:7086-7094.
5. Jha P, Sohn JH, Qin X, et al. Complement system plays a critical role in the development of experimental autoimmune anterior uveitis (EAAU). Invest Ophthalmol Vis Sci. 2006;47:1030-1038.
6. Sohn JH, Kaplan HJ, Suk HJ, Bora PS, Bora NS. Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci. 2000;41:3492-3502.
7. Sohn JH, Kaplan HJ, Suk HJ, Bora PS, Bora NS. Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59. Invest Ophthalmol Vis Sci. 2000;41:4195-4202.
8. Jha P, Sohn JH, Xu Q, Wang Y, Kaplan HJ, Bora PS, Bora NS. Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). J Immunol. 2006;176:7221-7231.
9. Vermeulen K, Van Bockstaele DR, Berneman ZN. Apoptosis: mechanisms and relevance in cancer. Ann Hematol. 2005;84:627-639.
10. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005;6:1191-1197.
11. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther. 2005;4:139-163.
12. Kaufmann SH, Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 2001;11:526-534.
13. Saikumar P, Dong Z, Weinberg JM, Venkatachalam MA. Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene. 1998;17:3341-3349.
14. Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med. 2005;258:479-517.
15. + T cells occurs in experimental autoimmune anterior uveitis (EAAU). Clin Exp Immunol. 1999;118:357-363.
16. Peerc A. A Manual for Histologic Technicians. 3rd ed. Boston: Little, Brown and Co.; 1972.
17. Yang P, Herzberg NH, Zhou H, Broersma L, de Smet M, Kijlstra A. Apoptosis of infiltrating cells in experimental autoimmune uveoretinitis. Chin Med J (Engl). 2000;113:643-646.
18. Poulaki V, Mitsiades N, Mastorakos G, Caspi RR, Chrousos GP, Bouzas E. Fas/Fas ligand-associated apoptosis in experimental autoimmune uveoretinitis in rodents: role of proinflammatory corticotropin-releasing hormone. Exp Eye Res. 2001;72:623-629.
19. Smith JR, Hart PH, Standfield SD, Coster DJ, Wing SJ, Williams KA. Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat. Br J Ophthalmol. 2000;84:205-211.
20. Li Q, Sun B, Matteson DM, O'Brien TP, Chan CC. Cytokines and apoptotic molecules in experimental melanin-protein induced uveitis (EMIU) and experimental autoimmune uveoretinitis (EAU). Autoimmunity. 1999;30:171-182.
21. + T cells in murine experimental allergic encephalomyelitis. Science. 1992;256;1213.
22. Taneja V, Taneja N, Paisansinsup T, et al. CD4 and CD8 T cells in susceptibility/protection to collagen-induced arthritis in HLA-DQ8-transgenic mice: implications for rheumatoid arthritis. J Immunol. 2002;168:5867-5875.
23. Gregory CD, Devitt A. The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology. 2004;113:1-14.
24. Meagher LC, Savill JS, Baker A, Fuller RW, Haslett C. Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. J Leuk Biol. 1993;52:269-273.
25. Savill JS, Wyllie AH, Henson JE, Henson PM, Haslett C. Macrophage phagocytosis of aging neutrophils in inflammation. J Clin Invest. 1989;83:865-875.
26. Hussain N, Wu F, Zhu L, Thrall RS, Kresch MJ. Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat. Am J Respir Cell Mol Biol. 1998;19:867-874.
27. Fan TJ, Han LH, Cong RS, Liang J. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai). 2005;37:719-727.
28. Huang W, Dobberfuhl A, Filippopoulos T, et al. Transcriptional up-regulation and activation of initiating caspases in experimental glaucoma. Am J Pathol. 2005;167:673-681.
29. Jomary C, Neal MJ, Jones SE. Characterization of cell death pathways in murine retinal neurodegeneration implicates cytochrome c release, caspase activation, and bid cleavage. Mol Cell Neurosci. 2001;18:335-346.
30. Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 2000;7:1166-1173.
31. Bora NS, Sohn JH, Bora PS, Kaplan HJ, Kulkarni P. Anti-inflammatory effects of specific cyclooxygenase 2, 5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). Ocul Immunol Inflamm. 2005;13:183-189.
32. Ryter SW, Kim HP, Hoetzel A, et al. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal. 2007;9:49-89.
33. Yang B, Johnson TS, Thomas GL, et al. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Kidney Int. 2002;62:1301-1313.
34. Sawatzky DA, Willoughby DA, Colville-Nash PR, Rossi AG. The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. Am J Pathol. 2006;168:33-41.
35. Degli Esposti M, Dive C. Mitochondrial membrane permeabilisation by Bax/Bak. Biochem Biophys Res Commun. 2003;304:455-461.
36. Padosch SA, Bottiger BW. Neuronal apoptosis following cerebral ischaemia: pathophysiology and possible therapeutic implications. Curr Opin Anaesthesiol. 2003;16:439-445.