Paxillin's LD4 motif interacts with bcl-2

Journal of Cellular Physiology

Volumn 214, Issue 3, 2008, Pages 655-661

  Sheibani, Nader ^a   Tang, Yixin ^a   Sorenson, Christine M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR; HIC 5 PROTEIN; INTEGRIN; LEUPAXIN; PAXILLIN; PROTEIN BCL 2; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; PEPTIDE; PHOSPHOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIUM CELL; KIDNEY DEVELOPMENT; KIDNEY EPITHELIUM; MORPHOGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; URETER; AMINO ACID SEQUENCE; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENE DELETION; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CYTOSKELETAL PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PAXILLIN; PEPTIDES; PHOSPHOPROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE DELETION; URETER;

EID: 38449107062     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21256     Document Type: Article

References (21)

1. Brown MC, Turner CE. 2004. Paxillin: Adapting to change. Physiol Rev 84:1315-1339.
2. Brown M, Perrotta J, Turner E. 1996. Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol 135:1109-1123.
3. Chandler D, El-Naggar AK, Brisbay S, Redline RW, McDonnell TJ. 1994. Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and human adult kidney: Evidence for the contribution of bcl-2 expression to renal carcinogenesis. Human Pathol 25:789-796.
4. Chay K, Park SS, Mushinski JF. 2002. Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine Pro-B lymphocytes. J Biol Chem 277:14521-14529.
5. Chen G-C, Turano B, Ruest PJ, Hagel M, Settleman J, Thomas SM. 2005. Regulation of rho and rac signaling to the actin cytoskeleton by paxillin during drosophila development. Mol Cell Biol 25:979-987.
6. Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM. 2002. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 22:901-915.
7. Lu PJ, Lu QL, Rughetti A, Taylor-Papadimitriou J. 1995. Bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells. J Cell Biol 129:1363-1378.
8. 3 integrins that elevates bcl-2 transcription. J Biol Chem 276:27757-27763.
9. Melendez J, Turners C, Avraham H, Steinberg S, Schaefer E, Sussman M. 2004. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 279:53516-53523.
10. Nor JE, Christensen J, Liu J, Peters M, Mooney DJ, Strieter RM, Polverini PJ. 2001. Up-regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res 61:2183-2188.
11. Novak DV, Korsmeyer SJ. 1994. Bcl-2 protein expression during murine development. Am J Pathol 145:61-73.
12. Sheibani N, Scheef EA, DiMaio TA, Wang Y, Kondo S, Sorenson CM. 2007. Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells. J Cell Physiol 210:616-625.
13. Sorenson CM. 2004. Interaction of bcl-2 with paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem 279:11368-11374.
14. Sorenson CM, Sheibani N. 1999. Focal adhesion kinase, paxillin and bcl-2: Analysis of expression, phosphorylation and association during morphogenesis. Dev Dyn 215:371-382.
15. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR. 1995. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol 268:F73-F8I.
16. Sorenson CM, Padanilam B, Hammerman MR. 1996a. Abnormal postpartum renal development and cystogenesis in the bcl-2-/- mouse. Am J Physiol 271:F18-4-F193.
17. Sorenson CM, Rogers SA, Hammerman MR. 1996b. Abnormal renal development in the Os/+ mouse is intrinsic to the kidney. Am J Physiol 271:F234-F238.
18. Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM. 2004. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol 165:371-381.
19. Tumbarello DA, Brown MC, Turner CE. 2002. The paxillin LD motifs. FEBS Lett 513:114-118.
20. Turner C. 2000. Paxillin and focal adhesion signaling. Nat Cell Biol 2:E231-E236.
21. West K, Zhang H, Brown M, Nikolopoulos S, Riedy M, Horwitz A, Turner C. 2001. The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol 154:161-176.