IFN-α competes with TNF-α for STAT-1α; molecular basis for immune escape of human colon adenocarcinoma COLO 205 cells

Oncology Reports

Volumn 18, Issue 4, 2007, Pages 1039-1045

  Pajak, Beata ^a   Orzechowski, Arkadiusz ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

COLO 205 cells; Immune escape; Interferons; STAT 1 ; TNF

Indexed keywords

ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; COLON TUMOR; CYTOPLASM; DRUG EFFECT; GENETICS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; WESTERN BLOTTING;

ADENOCARCINOMA; ANGIOGENESIS INHIBITORS; BLOTTING, WESTERN; CELL NUCLEUS; CELL SURVIVAL; COLONIC NEOPLASMS; CYTOPLASM; HUMANS; IMMUNOPRECIPITATION; INTERFERON-ALPHA; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; STAT1 TRANSCRIPTION FACTOR; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38449105965     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.18.4.1039     Document Type: Article

References (28)

1. Fischl MA, Uttamachandani RB, Resnick L, Agarwal R, Fletcher MA, Patrone-Reese J, Dearmas L, CHidekel J, McCann M, Myers M: A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma. J Acquir Immune Defic Syndr 4: 1-10, 1991.
2. Son MJ, Song HS, Kim MH, Kim JT, Kang CM, Jeon JW, Park SY, Kim YJ, Groves MD, Park K, Kim JH, Nam DH: Synergistic effect and condition of pegylated interferon alpha with paclitaxel on glioblastoma. Int J Oncol 28: 1385-1392, 2006.
3. Stark GR, Kerr IM, Williams BRG, Silverman RH, Schreiber RD: How cells respond to interferons. Ann Rev Biochem 67: 227-264, 1998. (Pubitemid 28411130)
4. Yang H, Grossniklaus HE: Combined immunologic and antiangiogenic therapy reduces hepatic micrometastases in a murine ocular melanoma model. Curr Eye Res 31: 557-562, 2006. (Pubitemid 43884602)
5. Pestka S: The human interferon α species and hybrid proteins. Semin. Oncology 24: S9-4-S9-7, 1997.
6. Pestka S, Kotenko SW, Muthukumaran G, Izotova LS, Cook JR, Garotta G: The interferon γ (IFN-γ) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev 15: 563-591, 1997.
7. Friedman RL, Stark GR: Alpha-interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature 341: 637-639, 1985. (Pubitemid 15080843)
8. Larner AC, Chaudhuri A, Darnell JEJ: Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. J Biol Chem 261: 453-459, 1986. (Pubitemid 16103967)
9. Darnell JEJ, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421, 1994. (Pubitemid 24217131)
10. Kumar A, Commane M, Flickinger TW, Horvath CM, Stark GR: Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278: 1630-1632, 1997. (Pubitemid 27516283)
11. Wang Y, Wu TR, Walte T, Chin YE: Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol 20: 4505-4512, 2000. (Pubitemid 30396098)
12. Loetscher H, Pan HC, Lahm HW, Gentz R, Brockhaus M, Tabuchi H, Lesslauer W: Molecular cloning and expression of the human 55 kDa tumor necrosis factor receptor. Cell 61: 351-359, 1990.
13. Schall TJ, Lewis M, Koller KJ, Lee A, Rich GC, Wong GHW, Gatanga T, Granger GA, Lentz R, Raab H: Molecular cloning and expression of a receptor for tumor necrosis factor. Cell 61: 361-370, 1990. (Pubitemid 120035001)
14. Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB: Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J Immunol 160: 2742-2750, 1998. (Pubitemid 28136727)
15. Wesemann DR, Qin H, Kokorina N, Benveniste EN: TRADD interacts with STAT1-α and influences interferon-γ signaling. Nature Immunol 5: 199-207, 2004. (Pubitemid 38208362)
16. 2-terminal protein kinase and apoptosis by tumor necrosis factor-α. J Cell Biochem 84: 803-815, 2002.
17. Bromberg J: STAT proteins in oncogenesis. J Clin Invest 109: 1139-1142, 2002.
18. Pajak B, Orzechowski A: Cycloxehimide-mediated sensitization to TNF-α-induced apoptosis in human colorectal cancer cell line COLO 205: role of FLIP and metabolic inhibitors. J Physiol Pharmacol 56: 101-118, 2005. (Pubitemid 43129237)
19. Jacobson MD, Burne JF, Raff MC: Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J 13: 1899-1910, 1994. (Pubitemid 24124523)
20. Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72: 248-254, 1976.
21. Percipalle P, Visa N: Molecular functions of nuclear actin in transcription. J Cell Biol 20: 1-5, 2006.
22. Pajak B, Gajkowska B, Orzechowski A: Position of STAT-1α in cycloheximide-dependent apoptosis triggered by TNF-α in human colorectal COLO 205 cancer cell line: role of polyphenolic compounds. J Physiol Pharmacol 56: 119-141, 2005. (Pubitemid 43129238)
23. Fulda S, Debatin KM: IFNγ sensitizes for apoptosis by upregulating caspase-8 expression through the STAT1 pathawy. Oncogene 21: 2295-2308, 2002. (Pubitemid 34407289)
24. Park SY, Seol JW, Lee YJ, Cho JH, Kang HS, Kim IS, Park SH, Kim TH, Yim JH, Kim M, Billiar TR, Seol DW: IFN-γ enhances TRAIL-induced apoptosis through IRF-1. Eur J Biochem 271: 4222-4228, 2004. (Pubitemid 39506751)
25. Abadie A, Besancon F, Wietzerbin J: Type I interferon and TNFα cooperate with type II interferon for TRAIL induction and triggering of apoptosis in SK-N-MC EWING tumor cells. Oncogene 23: 4911-4920, 2004. (Pubitemid 38932163)
26. Wesemann DR, Benveniste EN: STAT-1α and IFN-γ as modulators of TNF-α signaling in macrophages: regulation and functional implications of the TNF receptor 1: STAT-1α complex. J Immunol 171: 5313-5319, 2003. (Pubitemid 37432816)
27. Boudny V, Dusek L, Adamkova L, Chumchalova J, Kocak I, Fait V, Lauerova L, Krejci E, Kovarik J: Lack of STAT 1 phosphorylation at TYR 701 by IFNgamma correlates with disease outcome in melanoma patients. Neoplasma 52: 330-337, 2005. (Pubitemid 41076202)
28. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD: Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3: 991-998, 2002. (Pubitemid 35363648)