메뉴 건너뛰기




Volumn 19, Issue 10, 2007, Pages 793-801

Enantioselective analysis of citalopram and demethylcitalopram in human and rat plasma by chiral LC-MS/MS: Application to pharmacokinetics

Author keywords

Citalopram; Enantiomers; LC MS MS; Metabolism; Pharmacokinetics

Indexed keywords

CITALOPRAM; DEMETHYLCITALOPRAM; DRUG DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

EID: 38449102717     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20452     Document Type: Article
Times cited : (44)

References (22)
  • 1
    • 0032706936 scopus 로고    scopus 로고
    • Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes
    • Olesen OV, Linnet K. Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes. Pharmacology 1999;59: 298-309.
    • (1999) Pharmacology , vol.59 , pp. 298-309
    • Olesen, O.V.1    Linnet, K.2
  • 2
    • 0034074252 scopus 로고    scopus 로고
    • Stereoselective HPLC-assay for citalopram and its metabolites
    • Zheng Z, Jamour M, Klotz U. Stereoselective HPLC-assay for citalopram and its metabolites. Ther Drug Monit 2000;22: 219-224.
    • (2000) Ther Drug Monit , vol.22 , pp. 219-224
    • Zheng, Z.1    Jamour, M.2    Klotz, U.3
  • 3
    • 0034936466 scopus 로고    scopus 로고
    • Escitalopram (S-citalopram) and its metabolites in vitro: Cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram
    • Moltke LLV, Greenblatt DJ, Giancarlo GM, Granda BW, Harmatz JS, Sharder RI. Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram. Drug Metabol Dispos 2001;29: 1102-1109.
    • (2001) Drug Metabol Dispos , vol.29 , pp. 1102-1109
    • Moltke, L.L.V.1    Greenblatt, D.J.2    Giancarlo, G.M.3    Granda, B.W.4    Harmatz, J.S.5    Sharder, R.I.6
  • 4
    • 0036787115 scopus 로고    scopus 로고
    • Enantiomers' potential in psychopharmacology - A critical analysis with special emphasis on the antidepressant escitalopram
    • Baumann P, Zullino DF, EAP CB. Enantiomers' potential in psychopharmacology - A critical analysis with special emphasis on the antidepressant escitalopram. Eur Neuropsychopharmacol 2002;12: 433-444.
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 433-444
    • Baumann, P.1    Zullino, D.F.2    Eap, C.B.3
  • 5
    • 0034467642 scopus 로고    scopus 로고
    • Citalopram pharmacokinetics in patients with chronic renal failure and the effect of hemodialysis
    • Spigset O, Hägg S, Stegmayr B, Dahqvist R. Citalopram pharmacokinetics in patients with chronic renal failure and the effect of hemodialysis. Eur J Clin Pharmacol 2000;56: 699-703.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 699-703
    • Spigset, O.1    Hägg, S.2    Stegmayr, B.3    Dahqvist, R.4
  • 6
    • 0030682236 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of enantiomers of citalopram and its metabolites in humans
    • Shidu J, Priskorn M, Poulsen M, Segonzac A, Grollier G, Larsen F. Steady-state pharmacokinetics of enantiomers of citalopram and its metabolites in humans. Chirality 1997;9: 686-692.
    • (1997) Chirality , vol.9 , pp. 686-692
    • Shidu, J.1    Priskorn, M.2    Poulsen, M.3    Segonzac, A.4    Grollier, G.5    Larsen, F.6
  • 8
    • 0035047361 scopus 로고    scopus 로고
    • In vivo steady-state pharmacokinetic outcome following clinical and toxic doses of racemic citalopram to rats
    • Kugelberg FC, Apelqvist G, Carlsson B, Ahlner J, Bengtsson F. In vivo steady-state pharmacokinetic outcome following clinical and toxic doses of racemic citalopram to rats. Br J Pharmacol 2001;132: 1683-1690.
    • (2001) Br J Pharmacol , vol.132 , pp. 1683-1690
    • Kugelberg, F.C.1    Apelqvist, G.2    Carlsson, B.3    Ahlner, J.4    Bengtsson, F.5
  • 9
    • 0042164612 scopus 로고    scopus 로고
    • Stereoselective single- dose kinetics of citalopram and its metabolites in rats
    • Kugelberg FC, Carlsson B, Ahlner J, Bengtsson F. Stereoselective single- dose kinetics of citalopram and its metabolites in rats. Chirality 2003;15: 622-629.
    • (2003) Chirality , vol.15 , pp. 622-629
    • Kugelberg, F.C.1    Carlsson, B.2    Ahlner, J.3    Bengtsson, F.4
  • 10
    • 0029035234 scopus 로고
    • Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography
    • Rochat B, Amey M, Baumann P. Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography. Ther Drug Monit 1995;17: 273-279.
    • (1995) Ther Drug Monit , vol.17 , pp. 273-279
    • Rochat, B.1    Amey, M.2    Baumann, P.3
  • 11
    • 0028863052 scopus 로고
    • Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC
    • Rochat B, Amey M, Van Gelderen H, Testa B, Baumann P. Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC. Chirality 1995;7: 389-395.
    • (1995) Chirality , vol.7 , pp. 389-395
    • Rochat, B.1    Amey, M.2    Van Gelderen, H.3    Testa, B.4    Baumann, P.5
  • 12
    • 0030601723 scopus 로고    scopus 로고
    • Determination of citalopram enantiomers in human plasma by liquid chromatographic separation on a chiral-AGP column
    • Haupt D. Determination of citalopram enantiomers in human plasma by liquid chromatographic separation on a chiral-AGP column. J Chromatogr B 1996;685: 299-305.
    • (1996) J Chromatogr B , vol.685 , pp. 299-305
    • Haupt, D.1
  • 13
    • 0032553517 scopus 로고    scopus 로고
    • Analysis of enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography
    • Kosel M, Eap CB, Amey M, Baumann P. Analysis of enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography. J Chromatogr B 1998;719: 234-238.
    • (1998) J Chromatogr B , vol.719 , pp. 234-238
    • Kosel, M.1    Eap, C.B.2    Amey, M.3    Baumann, P.4
  • 14
    • 0041324638 scopus 로고    scopus 로고
    • Stereospecific determination of citalopram and desmethylcitalopram by capillary electrophoresis and liquid-phase microextraction
    • Andersen S, Halvorsen TG, Pedersen-Bjergaard S, Rasmussen KE, Tanum L, Refsun H. Stereospecific determination of citalopram and desmethylcitalopram by capillary electrophoresis and liquid-phase microextraction. J Pharm Biomed Anal 2003;33: 263-273.
    • (2003) J Pharm Biomed Anal , vol.33 , pp. 263-273
    • Andersen, S.1    Halvorsen, T.G.2    Pedersen-Bjergaard, S.3    Rasmussen, K.E.4    Tanum, L.5    Refsun, H.6
  • 15
    • 0345873426 scopus 로고    scopus 로고
    • Enantiomeric separation of citalopram and its metabolites by capillary electrophoresis
    • Mandrioli R, Fanali S, Pucci V, Raggi MA. Enantiomeric separation of citalopram and its metabolites by capillary electrophoresis. Electrophoresis 2003;24: 2608-2616.
    • (2003) Electrophoresis , vol.24 , pp. 2608-2616
    • Mandrioli, R.1    Fanali, S.2    Pucci, V.3    Raggi, M.A.4
  • 16
    • 0032697902 scopus 로고    scopus 로고
    • Metabolism and excretion of citalopram in man: Identification of O-acyl- and N-glucuronides
    • Dalgaard L, Larsen C. Metabolism and excretion of citalopram in man: identification of O-acyl- and N-glucuronides. Xenobiotica 1999; 29: 1033-1041.
    • (1999) Xenobiotica , vol.29 , pp. 1033-1041
    • Dalgaard, L.1    Larsen, C.2
  • 18
    • 2442517316 scopus 로고    scopus 로고
    • Multivariate approaches for efficient detection of potential metabolites from liquid chromatography/mass spectrometry data
    • Idborg H, Edlund PO, Jacobsson SP. Multivariate approaches for efficient detection of potential metabolites from liquid chromatography/mass spectrometry data. Rapid CommunMass Spectrom 2004;18: 944-954.
    • (2004) Rapid CommunMass Spectrom , vol.18 , pp. 944-954
    • Idborg, H.1    Edlund, P.O.2    Jacobsson, S.P.3
  • 19
    • 4544246095 scopus 로고    scopus 로고
    • Liquid chromatography-positive ion electrospray mass spectometry method for the quantification of citalopram in human plasma
    • Pistos C, Panderi I, Atta-Politou J. Liquid chromatography-positive ion electrospray mass spectometry method for the quantification of citalopram in human plasma. J Chromatogr B 2004;810: 235-244.
    • (2004) J Chromatogr B , vol.810 , pp. 235-244
    • Pistos, C.1    Panderi, I.2    Atta-Politou, J.3
  • 20
    • 7444233562 scopus 로고    scopus 로고
    • Liquid chromatography-electrospray ionization mass spectrometry method for the determination of escitalopram in human plasma and its application in bioequivalence study
    • Singh SS, Shah H, Gupta S, Jain M, Sharma K, Thakkar P, Shah R. Liquid chromatography-electrospray ionization mass spectrometry method for the determination of escitalopram in human plasma and its application in bioequivalence study. J Chromatogr B 2004;811: 209-215.
    • (2004) J Chromatogr B , vol.811 , pp. 209-215
    • Singh, S.S.1    Shah, H.2    Gupta, S.3    Jain, M.4    Sharma, K.5    Thakkar, P.6    Shah, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.