Rectal versus intravenous quinine for the treatment of childhood cerebral malaria in Kampala, Uganda: A randomized, double-blind clinical trial

Clinical Infectious Diseases

Volumn 45, Issue 11, 2007, Pages 1446-1452

  Achan, Jane ^a   Byarugaba, Justus ^a   Barennes, Hubert ^b   Tumwine, James K ^a  

^a MAKERERE UNIVERSITY   (Uganda)

^b Institut Francophone de Medecine Tropicale   (Laos)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; QUINIMAX; QUININE; ANTIMALARIAL AGENT;

ABNORMAL FECES COMPOSITION; ARTICLE; BRAIN MALARIA; CHILD; CHILD DEVELOPMENT; CLINICAL TRIAL; COMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEVER; HUMAN; HYPOGLYCEMIA; HYPOTENSION; INFANT; JAUNDICE; LIQUID FECES; MAJOR CLINICAL STUDY; PARASITE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RASH; UGANDA; VOMITING; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALARIA; PRESCHOOL CHILD; RECTAL DRUG ADMINISTRATION;

ADMINISTRATION, RECTAL; ANTIMALARIALS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; HUMANS; INJECTIONS, INTRAVENOUS; MALARIA, CEREBRAL; QUININE; UGANDA;

EID: 38449092730     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/522972     Document Type: Article

References (25)

1. World Health Organization. Severe falciparum malaria. Trans R Soc Trop Med Hyg 2000; 94:1-2.
2. Marsh K, Forster B, Waruiru C, Mwangi I, Winstanley M, Marsh V. Indicators of life threatening malaria in African children. N Engl J Med 1995; 332:1399-404.
3. Dondorp A, Nosten F, Stepniewska K, Day N, White N; South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. Artesunate versus quinine for treatment of severe falciparum malaria: a randomized trial. Lancet 2005; 366:717-25.
4. Wyatt H, Mahadevan S, Srinivasan S. Unnecessary injections and paralytic poliomyelitis in India. Trans R Soc Trop Med Hyg 1992; 86:546-9.
5. Simonsen L, Kane A, Lloyd J, Zaffran M, Kane M. Unsafe injections in the developing world and transmission of blood borne pathogens: a review. Bull WHO 1999; 77:789-800.
6. Barennes H, Pussard E, Mahaman Sani A, et al. Efficacy and pharmokinetics of a new quinine formulation in children with Plasmodium falciparum malaria. Br J Clin Pharmacol 1996; 41:389-95.
7. Barennes H, Kahiatani F, Pussard E, et al. Intrarectal Quinimax for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics. Trans R Soc Trop Med Hyg 1995; 89: 418-21.
8. Barennes H, Sterlingot H, Nagot N, et al. Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria. Eur J Clin Pharmacol 2003; 58:649-52.
9. Pussard E, Straczek C, Kabore I, Bicaba B, Balima-Kousssoube T, Bourree P. Dose-dependent resorption of quinine after intrarectal administration to children with moderate falciparum malaria. Antimicrob Agents Chemother 2004; 48:4422-6.
10. Barennes H, Pussard E, Mahaman Sani A. Intrarectal quinimax (a cinchona alkaloid association) administered at 3 progressive doses to P. falciparum malaria in children in Niger. Clin Drug Invest 1996; 11: 154-8.
11. Barennes H, Pussard E, Mahaman-Sani A, et al. Efficacy and pharmacokinetics of a new rectal quinine formulation in children with P. falciparum malaria. Brit J Clin Pharmacol 1996; 41:389-95.
12. Teasdale G, Jennet B. Assessment of coma and impaired consciousness: a practical scale. Lancet 1974; 2:81-4.
13. Uganda Ministry of Health. National malaria treatment guidelines. 2nd ed. Kampala, Uganda: Uganda Ministry of Health, 2003.
14. Aceng JR, Byarugaba JS, Tumwine JK. Rectal arthemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomized clinical trial. BMJ 2005; 330:334-6.
15. Barennes H, Munjakazi J, Verdier F. An open randomized clinical study of intrarectal versus infused quinimax for the treatment of childhood cerebral malaria. Trans R Soc Trop Med Hyg 1998; 92:437-40.
16. Eisenhut M, Omari AAA. Intrarectal quinine for treating Plasmodium falciparum malaria. Cochrane Database of Systematic Reviews 2005: CD004009.
17. Brewer TG, Peggins JO, Grate SJ, et al. Neurotoxicity in animals due to arteether and artemether. Trans R Soc Trop Med Hyg 1994; 88(Suppl 1):S33-6.
18. Hensbroek M, Emeka O, Shabbar J. A trial of artemether or quinine in children with cerebral malaria. N Engl J Med 1996; 335:69-75.
19. Assamadi JK, Gbadoe AD, Agbodjan-Djossou O. Diluted injectable quinine in the intramuscular and intrarectal route: comparative efficacy and tolerance in malaria treatment in children. Med Trop Mars 2002; 62:158-62.
20. Esamai F, Ayou P, Owino-Ongor W, et al. Rectal dihydroartemesinin versus intravenous quinine in the treatment of severe malaria: a randomised clinical trial. East Afr Med J 2000; 77:273-7.
21. Barennes H, Balima-Koussoube T, Nagot N, Charpentier JC, Pussard E. Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomized clinical trial. BMJ 2006; 332:1055-9.
22. Druilhe P, Brandicourt O, Chongsuphajaisiddhi T, Berthe J. Activity of a combination of three cinchona alkaloids against Plasmodium falciparum in vitro. Antimicrob Agents Chemother 1988; 32:250-4.
23. Newton C, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther 1998; 79:1-53.
24. Molyneux ME, Taylor TT, Wirima JJ, Borgstein. Clinical features and prognostic indicators in pediatric cerebral malaria: a study of 131 comatose Malawian children. Quart J Med 1989; 71:441-59.
25. Barennes H, Kailon D, Pussard E, Munjakazi JM, Fernan M, Sherouat H. Intrarectal administration of quinine: an early treatment for severe malaria in children? Sante 2001; 11:145-53.