Intrarectal Quinimax® (a combination of Cinchona alkaloids) administered at 3 different dosages to children with Plasmodium falciparum malaria in Niger

Clinical Drug Investigation

Volumn 11, Issue 3, 1996, Pages 154-158

  Barennes, H ^a   Pussard, E ^b   Mahaman Sani, A ^c   Clavier, F ^b   Henzel, D ^b   Kahiatani, F ^d   Granic, G ^d   Ravinet, L ^e   Verdier, F ^b,f  

^a Min de la S Publique du Niger   (Niger)

^b INSERM   (France)

^c Fac des Sci Medicales de Niamey   (Niger)

^d Hôpital de Niamey   (Niger)

^e SANOFI   (France)

^f BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CINCHONA ALKALOID; CINCHONIDINE; CINCHONINE; QUINIDINE; QUINIMAX; QUININE;

ADOLESCENT; ARTICLE; BODY TEMPERATURE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MIXTURE; FEMALE; HUMAN; HUMAN CELL; MALARIA; MALE; NIGER; PARASITEMIA; PARASITOLOGY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION;

EID: 0029922981     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199611030-00005     Document Type: Article

References (5)

1. Barennes H, Kahiatani F, Pussard E, et al. Intrarectal Quinimax® (a cinchona alkaloids association) for the treatment of Plasmodium falciparum malaria in children in Niger: efficacy and pharmacokinetics. Tr R Soc Trop Med Hyg 1995; 89: 418-21
2. Iliadis A, Brown C, Huggins ML. Apis: a software for model identification, simulation and dosage regimens calculation in clinical and experimental pharmacokinetics. Comput Meth Progr Biomed 1992; 38: 227-39
3. White NJ. Antimalarial pharmacokinetics and treatment regimens. Br J Clin Pharmacol 1992; 34: 1-10
4. White NJ, Warrell DA, Looreesuwan S, et al. Quinine loading dose in cerebral malaria. Am J Trop Med Hyg 1983; 32: 1-5
5. White NJ, Looareesuwan S, Warrell DA, et al. Quinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria. Am J Med 1982; 73: 564-72