Unsafe injections in the developing world and transmission of bloodborne pathogens: A review

Bulletin of the World Health Organization

Volumn 77, Issue 10, 1999, Pages 789-800

  Simonsen, L ^a   Kane, A ^b   Lloyd, J ^a   Zaffran, M ^a   Kane, M ^c  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

^b DUKE UNIVERSITY   (United States)

^c PATH   (United States)

Author keywords

Bloodborne pathogens; Disease transmission; Hepatitis B; Hepatitis C; HIV infections; Horizontal; Syringes

Indexed keywords

DEVELOPING WORLD; DISEASE TRANSMISSION; HEALTH CARE; INFECTIOUS DISEASE;

DEVELOPING COUNTRY; DISEASE TRANSMISSION; EBOLA VIRUS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN IMMUNODEFICIENCY VIRUS; INJECTION; INSTITUTIONAL CARE; INSTRUMENT STERILIZATION; LASSA VIRUS; MALARIA; NEEDLE; NEEDLESTICK INJURY; REVIEW; SAFETY; SYRINGE;

BEHAVIOR; BIOLOGY; COMMUNICABLE DISEASES; DEVELOPING COUNTRIES; DISEASES; EQUIPMENT AND SUPPLIES; HEPATITIS--TRANSMISSION; HIV INFECTIONS--TRANSMISSION; INFECTIONS; LITERATURE REVIEW; MEASUREMENT; PREVALENCE; RESEARCH METHODOLOGY; RISK BEHAVIOR; RISK FACTORS; SYRINGE; VIRAL DISEASES;

ADULT; BLOOD-BORNE PATHOGENS; CROSS INFECTION; DEVELOPING COUNTRIES; HEPATITIS B; HEPATITIS C; HIV INFECTIONS; HUMANS; INFECTION CONTROL; INJECTIONS; POPULATION SURVEILLANCE; PREVALENCE; SAFETY; UNNECESSARY PROCEDURES; WORLD HEALTH;

EID: 0032726232     PISSN: 00429686     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (85)

1. State of the world's vaccines and immunization, Geneva, World Health Organization/United Nations Children's Fund, 1996:159.
2. Medical Research Council. Reports of the Salvarsan Committee II. Toxic effects following the employment of arsenobenzol preparations. London, His Majesty's Stationery Office, 1922: 56.
3. Role of syringes in the transmission of jaundice. A memorandum by medical officers of the ministry of health. Lancet, 1945, July 28: 116-119.
4. Expanded Programme on Immunization. Changing needles but not the syringe: an unsafe practice. Weekly epidemiological record, 1987, 62: 345-352.
5. Lutz CT et al. Allergy testing of multiple patients should no longer be performed with a common syringe. New England journal of medicine, 1984, 310: 1335-1337.
6. Fleming A, Ogilvie A.C. Syringe needles and mass inoculation technique. British medical journal, 1951, (March 17): 543-546.
7. Collins CH, Kennedy DA. Microbiological hazards of occupational needlestick and 'sharps' injuries. Journal of applied bacteriology, 1987, 62: 385-402.
8. Kane M. Unsafe injections. Bulletin of the World Health Organization, 1998, 76: 99-100.
9. Hu DJ, Kane MA, Heymann DL. Transmission of HIV, hepatitis B virus, and other bloodborne pathogens in health care settings: a review of risk factors and guidelines for prevention. Bulletin of the World Health Organization, 1991, 69: 623-630.
10. Darwish MA et al. Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors. American journal of tropical medicine and hygiene, 1993, 49: 440-447.
11. Farghaly AG, Barakat RM. Prevalence, impact and risk factors of hepatitis C infection. Journal of the Egyptian Public Health Association, 1993, 68: 63-79.
12. Hersh BS et al. Acguired immunodeficiency syndrome in Romania. Lancet, 1991, 338: 645-649.
13. Wyatt HV. The popularity of injections in the Third World: origins and consequences for poliomyelitis. Social science and medicine, 1984, 19: 911-915.
14. Cunningham CE. Thai "injection doctors"; antibiotic mediators. Social science and medicine, 1970, 4: 1-24.
15. Ferguson AE. Commercial pharmaceutical medicine and medicalization: a case study from El Salvador. Culture, medicine and psychiatry, 1981, Jun. 5: 105-134.
16. Whyte SR. Pharmaceuticals as folk medicine: transformations in the social relations of health care in Uganda. Culture, medicine and psychiatry, 1992, Jun. 16: 163-186.
17. van der Geest S. The illegal distribution of Western medicines in developing countries: pharmacists, drug pedlars, injection doctors and others. A bibliographic exploration. Medical anthropology, 1982, 4197-4219.
18. Anonymous: High frequency of injections among Chisinau residents, Republic of Moldova. 1998. Weekly epidemiological record, 1999, 11: 84-86.
19. Wyatt HV, Mahadevan S. Unnecessary injections and poliomyelitis. Indian journal of pediatrics, 1993, 60: 327-329.
20. Pokrovskii VV et al. [An intrahospital outbreak of HIV infection in Elista]. Zhurnal Mikrobiologii, Epidemiologii, Immunobiologii, 1990, (April): 17-23 (in Russian).
21. Lepage P, Van de Perre P. Nosocomial transmission of HIV in Africa: what tribute is paid to contaminated blood transfusions and medical injections? Infection control and hospital epidemiology, 1988, 9: 200-203.
22. Mann JM et al. Risk factors for human immunodeficiency virus seropositivity among children 1-24 months old in Kinshasa, Zaire. Lancet, 1986, 2: 654-657.
23. WHO Expanded Programme on Immunization. Country reports (including special studies of injection safety). Geneva, World Health Organization, 1998 (unpublished documents).
24. Gumodoka B et al. Injection practices in Mwanza Region, Tanzania: prescriptions, patient demand and sterility. Tropical medicine and international health, 1996, 1: 874-880.
25. Hogeboom van Buggenum I et al. eds. Injections in Indonesia. In: The impact of injections on daily medical practice. Amsterdam, VU University Press, 1993: 77-91.
26. Greenhalgh T. Drug prescription and self-medication in India: an exploratory survey. Social science and medicine, 1987, 25: 307-318.
27. Loukina TN. [Current treatment methods for the respiratory infections in children]. Thesis for the degree of candidate of medical sciences. Moscow, Institute of Pediatrics, 1993 (in Russian).
28. Stekolschikova IA. [Diagnostic and treatment tactics in the management of ARI in children]. Thesis for the degree of candidate of medical sciences. Moscow, Institute of Pediatrics, RAMS, 1993 (in Russian).
29. van Staa A, Hardon A. Injection practices in the developing world: a comparative review of field studies in Uganda and Indonesia. Geneva, World Health Organization, 1996 (unpublished document WHO/DAP/96.4; available upon request from Essential Drugs and other Biologicals, World Health Organization, 1211 Geneva 27, Switzerland).
30. Reeler AV, Hematorn C. Injection practices in the third world. A case study of Thailand. Geneva, World Health Organization, 1994 (unpublished document WHO/DAP/94.8; available upon request from Essential Drugs and other Biologicals, World Health Organization, 1211 Geneva 27, Switzerland).
31. Guyer B, Candy D. Injectable antimalaria therapy in tropical Africa: iatrogenic disease and waste medical resources. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979, 73: 230-232.
32. Janszen E et al., eds. Injections: more expensive, more effective and faster. A report from Equador. In: The impact of injections on daily medical practice. Amsterdam, VU University Press, 1993: 43-56.
33. Ugalde A et al. eds. Medicines and rural health services: an experiment in the Dominican Republic. In: Sjaak van der Geest & Whyte SR. The context of medicines in developing countries. Dordrecht, Kluwer Academic Publishers, 1988: 57-79.
34. Koziol DE, Henderson D. Risk analysis and occupational exposure to HIV and HBV. Current opinions on infectious diseases, 1993, 6: 506-510.
35. Werner BG, Grady GF. Accidental hepatitis-B-surface-antigen-positive inoculations. Use of e antigen to estimate infectivity. Annals of internal medicine, 1982, 97: 367-369.
36. Owens DK, Nease RFJ. Occupational exposure to human immunodeficiency virus and hepatitis B virus: a comparative analysis of risk. American journal of medicine, 1992, 92: 503-512.
37. Grady GF, Lee VA. Hepatitis B immune globulin - prevention of hepatitis from accidental exposure among medical personnel. New England journal of medicine, 1975, 293: 1067-1070.
38. McMahon BJ et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. Journal of infectious diseases, 1985, 151 (4): 599-603.
39. Sodeyama T et al. Detection of hepatitis C virus markers and hepatitis C virus genomic-RNA after needlestick accidents. Archives of internal medicine, 1993, 153: 1565-1572.
40. Mizuno Y et al. Study of needlestick accidents and hepatitis C virus infection in healthcare workers by molecular evolutionary analysis Journal of hospital infections, 1997, 35: 149-154.
41. Arai Y et al. A prospective study of hepatitis C virus infection after needlestick accidents. Liver, 1996, 16: 331-334.
42. Lanphear BP et al. Hepatitis C virus infection in healthcare workers risk of exposure and infection. Infection control and hospital epidemiology, 1994, 15: 745-750.
43. Mitsui T et al. Hepatitis C virus infection in medical personnel after needlestick accidents. Hepatology, 1992, 16: 1109-1114.
44. Owens D et al. Occupational exposure to human immunodeficiency virus and hepatitis B virus: A comparative analysis of risk. American journal of medicine, 1992, 92: 503-512.
45. Marcus R et al. Surveillance of health care workers exposed to blood from patients infected with the human immunodeficiency virus. New England journal of medicine, 1988, 319 (17): 1118-1123.
46. Gerberding JL. Incidence and prevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and cytomegalovirus among health care personnel at risk for blood exposure: final report from a longitudinal study. Journal of infectious diseases, 1994, 170 (6): 1410-1417.
47. Henderson DK et al. Risk for cccupational transmission of human immunodeficiency virus type 1 (HIV-1) associated with clinical exposures. A prospective evaluation. Annals of internal medicine, 1990, 113 (10): 740-746.
48. Culver J. Preventing transmission of blood-borne pathogens: a compelling argument for effective device-selection strategies. American journal of infection control, 1997, 25 (5): 430-433.
49. Report on the qlobal HIV/AIDS epidemic, June 1998. Geneva, United Nations Joint Programme on HIV/AIDS, 1998 (unpublished document UNAIDS/98.10; available upon request from United Nations Joint Programme on HIV/AIDS, 1211 Geneva 27, Switzerland).
50. Hepatitis C: global prevalence. Weekly epidemiological record, 1997, 72 (46): 341-344.
51. Kane, M. Country-specific hepatitis B carrier rates, by world countries and regions. World Health Organization/Expanded Programme on Immunization, Geneva, 1998 (unpublished document).
52. Outbreak of Ebola hemorrhagic fever - Zaire, 1995. Epidemiological bulletin, 1995, 16: 16.
53. Fisher-Hoch SP et al. Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. British medical journal, 1995, 311: 857-859.
54. Abulrahi HA et al. Plasmodium falciparum malaria transmitted in hospital through heparin locks. Lancet, 1997, 349: 23-25.
55. Hersh BS et al. Risk factors for HIV infection among abandoned Romanian children. AIDS, 1993, 7: 1617-1624.
56. Christensen C. Cluster of HIV-1 infection among children in Indian Hospital in Bombay. Informal report to WHO, September 1998. Copenhagen, Department of Virology, Statens Serum Institute, 1998.
57. Hutin Y et al. Evidence of injections given in different health care settings as a major source of acute hepatitis B among adults in Moldova. International journal of epidemiology, 1999, 28 (4): 782-786.
58. Hutin YJF et al. Using surveillance data to monitor key aspects of the epidemiology of hepatitis B virus (HBV) infection in Romania, Abstract presented at the annual meeting of the Infectious Diseases Society of America, Denver, Colorado, November 1999.
59. Beasley RP et al. Incidence of hepatitis B virus infections in preschool children in Taiwan. Journal of infectious diseases, 1982, 146: 193-204.
60. Hsu SC et al. Horizontal transmission of hepatitis B virus in children. Journal of pediatric gastroenterology and nutrition, 1993, 16: 66-69.
61. Ko YC et al. Horizontal transmission of hepatitis B virus from siblings and intramuscular injection among preschool children in a familial cohort. American journal of epidemiology, 1991, 133: 1015-1023.
62. Narendranathan M, Philip M. Reusable needles - a major risk factor for acute virus B hepatitis. Tropical doctor, 1993, 23: 64-66.
63. Ma J et al. [A study on the relationship between disinfection of syringes, acupuncture needles, transfusion sets and HBV infection in children under 2 years]. Chinese journal of virology, 1991, 7 (suppl): 30-34 (in Chinese).
64. Frank C et al. The role of antischistosomal mass injection treatment in the spread of hepatitis C virus infection in Egypt. [Abstract] Paper presented at: International Conference on Emerging Infectious Diseases, Atlanta, 8-11 March, 1998.
65. Ho MS et al. High rate of hepatitis C virus infection in an isolated community: persistent hyperendemicity or period-related phenomena? Journal of medical virology, 1997, 52: 370-376
66. Luby SP et al. The relationship between therapeutic injections and high prevalence of hepatitis C infection in Hafizabad, Pakistan. Epidemiology and infection, 1997, 119: 349-356.
67. EPI Information system, global summary. Geneva, World Health Organization, 1998: 26 (unpublished document WHO/EPI/GEN/ 98.10.; available upon request from Essential Drugs and other Biologicals, World Health Organization, 1211 Geneva 27, Switzerland).
68. Davies SC. Blood transfusion in sickle cell disease. Current opinions in hematology, 1996, 3: 485-491.
69. Aylward B et al. Model-based estimates of the risk of human immunodeficiency virus and hepatitis B virus transmission through unsafe injections. International journal of epidemiology, 1995, 24: 446-452.
70. Ticklay IM et al. HIV infection in malnourished children in Harare, Zimbabwe. East African medical journal, 1997, 74: 217-220.
71. Diop Mar I, Badiane S, Sow A. [Tetanus as a result of intramuscular injection]. Bulletin de la Socíété Médicale d'Afrique Noire de la Langue Française, 1977, 22: 72-83 (in Frerch).
72. Sow S et al. [Tetanus after intramuscular injection in an infectious disease service in Dakar. 12-year review (1978-1989)] Dakar médical, 1990, 35: 198-204 (in French).
73. Wyatt HV. Unnecessary injections and poliomyelitis in Pakistan. Tropical doctor, 1996, 26: 179-180.
74. Wyatt HV, Mahadevan S, Srinivasan S. Unnecessary injections and paralytic poliomyelitis in India. Transactions of the Royal Society of Tropical Medicine and hygiene, 1992, 86: 546-549.
75. Guyer B et al. Injections and paralytic poliomyelitis in tropical Africa. Bulletin of the World Health Organization, 1980, 58: 285-291.
76. Wyatt HV. Mothers, injections and poliomyelitis. Social science and medicine, 1992, 35: 795-798.
77. Birungi H. Injections and self-help: risk and trust in Ugandan health care. Social science and medicine, 1998, 47: 1455-1462.
78. Kane A et al. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates. Bulletin of the World Health Organization, 1999, 77: 801-807.
79. Vos J et al. Improved injection practices after the introduction of treatment and sterility guidelines in Tanzania. Tropical medicine and international health, 1998, 3: 291-296.
80. Dentinger C et al. Therapeutic Injections in Romania: A population survey in four districts. Abstract presented at the annual meeting of the Society for Healthcare Epidemiology of America, San Francisco, USA, April 1999.
81. Raglow G, Luby SP, Nabi N. Therapeutic injections in Pakistan: knowledge, attitudes and practice among patients presenting to a university clinic. Social science and medicine (submitted).
82. Vincent-Ballereau F, Lafaix C, Haroche G. Incidence of intramuscular injections in rural dispensaries in developing countries. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989, 83: 106.
83. Soeters R, Aus C. Hazards of injectable therapy. Tropical doctor, 1989, 19: 124-126.
84. Khan AJ et al. The dynamic of frequent injection behaviour and its relationship to hepatitis C infection among patients attending clinics in periurban Karachi. Bulletin of the World Health Organization (unpublished data).
85. Singh J et al. Outbreak of viral hepatitis B in a rural community in India linked to inadeguately sterilized needles and syringes. Bulletin of the World Health Organization, 1998, 76: 93-98.