Spatial differences in biologic activity of large uterine leiomyomata

Fertility and Sterility

Volumn 85, Issue 1, 2006, Pages 179-187

  Wei, Jian Jun ^a,b   Zhang, Xing Min ^a   Chiriboga, Luis ^a   Yee, Herman ^a   Perle, Mary A ^a   Mittal, Khush ^a  

^a BELLEVUE HOSPITAL CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

ER; Hypoxia; Immunohistochemistry; Leiomyosarcoma; PR; Three dimensions; Tissue microarray; Uterine leiomyoma

Indexed keywords

BLOOD CLOTTING FACTOR 8; CD24 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOCORTICOID RECEPTOR; HIGH MOBILITY GROUP A2 PROTEIN; HYALIN; HYPOXIA INDUCIBLE FACTOR 1; KI 67 ANTIGEN; PROTEIN BCL 2; RETINOID X RECEPTOR ALPHA; SOMATOMEDIN B; VASCULOTROPIN;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MYOMETRIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; TISSUE DISTRIBUTION; TISSUE GROWTH; TISSUE MICROARRAY; UTERUS MYOMA; VASCULARIZATION;

ADULT; APOPTOSIS; CELL DIVISION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH SUBSTANCES; HUMANS; LEIOMYOMATOSIS; LEIOMYOSARCOMA; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; UTERINE NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 30344441218     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.07.1294     Document Type: Article

References (28)

1. D. Day Baird, D.B. Dunson, M.C. Hill, D. Cousins, J.M. Schectman High cumulative incidence of uterine leiomyoma in black and white women ultrasound evidence Am J Obstet Gynecol 188 2003 100 107
2. N. Varol, M. Healey, P. Tang, P. Sheehan, P. Maher, D. Hill Ten-year review of hysterectomy morbidity and mortality can we change direction? Aust N Z J Obstet Gynaecol 41 2001 295 302
3. S.Z. Zhao, J.M. Wong, L.M. Arguelles Hospitalization costs associated with leiomyoma Clin Ther 21 1999 563 575
4. G.P. Flake, J. Andersen, D. Dixon Etiology and pathogenesis of uterine leiomyomas a review Environ Health Perspect 111 2003 1037 1054
5. B. Davis Uterine leiomyoma longitudinal interventions studies the Fibroid Growth Study Advances in uterine leiomyoma research 2nd NIH International Congress; 2005 2005 NIH Bethesda (MD)
6. J.J. Wei, L. Chiriboga, K. Mittal Expression profile of the tumorigenic factors in association with tumor size and sex steroid hormone status in uterine leiomyomata Fertil Steril 84 2 2005 474 484
7. T.J. Colgan, S. Pendergast, M. LeBlanc The histopathology of uterine leiomyomas following treatment with gonadotropin-releasing hormone analogues Hum Pathol 24 1993 1073 1077
8. A.J. Friedman, M. Daly, M. Juneau-Norcross, R. Gleason, M.S. Rein, M. LeBoff Long-term medical therapy for leiomyomata uteri a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin "add-back" for 2 years Hum Reprod 9 1994 1618 1625
9. J. Wei, L. Chiriboga, M. Mizuguchi, H. Yee, K. Mittal Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata Mod Pathol 18 2005 179 188
10. S.D. Gamage, E.D. Bischoff, K.D. Burroughs, W.W. Lamph, M.M. Gottardis, C.L. Walker Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma J Pharmacol Exp Ther 295 2000 677 681
11. A.A. Arslan, L.I. Gold, K. Mittal, T.C. Suen, I. Belitskaya-Levy, M.S. Tang Gene expression studies provide clues to the pathogenesis of uterine leiomyoma new evidence and a systematic review Hum Reprod 20 4 2005 852 863
12. J.C. Tsibris, J. Segars, D. Coppola, S. Mane, G.D. Wilbanks, W.F. O'Brien Insights from gene arrays on the development and growth regulation of uterine leiomyomata Fertil Steril 78 2002 114 121
13. K.M. Skubitz, A.P. Skubitz Differential gene expression in uterine leiomyoma J Lab Clin Med 141 2003 297 308
14. W.S. Ahn, K.W. Kim, S.M. Bae, J.H. Yoon, J.M. Lee, S.E. Namkoong Targeted cellular process profiling approach for uterine leiomyoma using cDNA microarray, proteomics and gene ontology analysis Int J Exp Pathol 84 2003 267 279
15. B.J. Quade, T.Y. Wang, K. Sornberger, P.D. Cin, G.L. Mutter, C.C. Morton Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling Genes Chromosomes Cancer 40 2004 97 108
16. H. Wang, M. Mahadevappa, K. Yamamoto, Y. Wen, B. Chen, J.A. Warrington Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata Fertil Steril 80 2003 266 276
17. W.H. Catherino, C. Prupas, J.C. Tsibris, P.C. Leppert, M. Payson, L.K. Nieman Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology Fertil Steril 80 2003 282 290
18. N. Chegini, J. Verala, X. Luo, J. Xu, R.S. Williams Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy J Soc Gynecol Investig 10 2003 161 171
19. G. Weston, A.C. Trajstman, C.E. Gargett, U. Manuelpillai, B.J. Vollenhoven, P.A. Rogers Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium Mol Hum Reprod 9 2003 541 549
20. P.J. Hoffman, D.B. Milliken, L.C. Gregg, R.R. Davis, J.P. Gregg Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis Fertil Steril 82 2004 639 649
21. K. Bodner, B. Bodner-Adler, O. Kimberger, K. Czerwenka, K. Mayerhofer Bcl-2 receptor expression in patients with uterine smooth muscle tumors an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma J Soc Gynecol Investig 11 2004 187 191
22. W. Catherino, A. Salama, C. Potlog-Nahari, P. Leppert, J. Tsibris, J. Segars Gene expression studies in leiomyomata new directions for research Semin Reprod Med 22 2004 83 90
23. K.A. Kovacs, F. Lengyel, J.L. Kornyei, Z. Vertes, I. Szabo, B. Sumegi Differential expression of Akt/protein kinase B, Bcl-2 and Bax proteins in human leiomyoma and myometrium J Steroid Biochem Mol Biol 87 2003 233 240
24. S. Guller, R. Wozniak, M.I. Leibman, C.J. Lockwood Negative regulation of placental fibronectin expression by glucocorticoids and cyclic adenosine 3′,5′-monophosphate Ann N Y Acad Sci 734 1994 132 142
25. V. Tse, L. Xu, Y.C. Yung, J.G. Santarelli, D. Juan, K. Fabel The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture Neurol Res 25 2003 729 738
26. I. Serganova, M. Doubrovin, J. Vider, V. Ponomarev, S. Soghomonyan, T. Beresten Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice Cancer Res 64 2004 6101 6108
27. L. Deligdisch, S. Hirschmann, A. Altchek Pathologic changes in gonadotropin releasing hormone agonist analogue treated uterine leiomyomata Fertil Steril 67 1997 837 841
28. J.P. Pelage, N.G. Guaou, R.C. Jha, S.M. Ascher, J.B. Spies Uterine fibroid tumors long-term MR imaging outcome after embolization Radiology 230 2004 803 809