Dexamethsone suppresses bone formation via the osteoclast

Advances in Experimental Medicine and Biology

Volumn 602, Issue , 2007, Pages 43-46

  Kim, Hyun Ju ^a   Zhao, Haibo ^a   Kitaura, Hideki ^a   Bhattacharyya, Sandip ^a   Brewer, Judson A ^a   Muglia, Louis J ^a   Ross, F Patrick ^a   Teitelbaum, Steven L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GELATINASE B; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 1; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; RAC PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

BONE MALFORMATION; BONE MASS; BONE REMODELING; CELL DIFFERENTIATION; CELL DISRUPTION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CORTICOSTEROID INDUCED OSTEOPOROSIS; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; CYTOSKELETON; ENZYME ACTIVATION; ENZYME INHIBITION; EXPERIMENTAL MOUSE; HUMAN; MACROPHAGE; MAMMAL CELL; MITOSIS INHIBITION; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; TARGET CELL; ANIMAL; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; DRUG EFFECT; METABOLISM; OSTEOBLAST;

ANIMALS; BONE RESORPTION; CELLS, CULTURED; DEXAMETHASONE; GLUCOCORTICOIDS; HUMANS; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RANK LIGAND;

EID: 38449085535     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-72009-8_5     Document Type: Conference Paper

References (17)

1. Aubin, J.E. 1999. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J Cell Biochem 72: 396-410.
2. Chellaiah, M.A., N. Soga, S. Swanson, S. McAllister, U. Alvarez, D. Wang, S.F. Dowdy, and K.A. Hruska. 2000. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem 275: 11993-12002.
3. Dempster, D.W. 1989. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 4: 137-141.
4. Faccio, R., S.L. Teitelbaum, K. Fujikawa, J.C. Chappel, A. Zallone, V.L. Tybulewicz, F.P. Ross, and W. Swat, 2005. Vav3 regulates osteoclast function and bone mass. Nat Med 11: 284-290.
5. Hirayama, T., A. Sabokbar, and N.A. Athanasou, 2002. Effect of corticosteroids on human osteoclast formation and activity. J Endocrinol 175: 155-163.
6. Hofbauer, L.C., F. Gori, B.L. Riggs, D.L. Lacey, C.R. Dunstan, T.C. Spelsberg, and S. Khosla, 1999. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinol 140: 4382-4389.
7. Kim, H.-J., H. Zhao, H. Kitaura, S. Bhattacharyya, J.A. Brewer, L.J. Muglia, F.P. Ross, and S.L. Teitelbaum. 2006. Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest 116: 2152-2160.
8. Korhonen, M., H. Zhao, R. Faccio, F.P. Ross, T.M. Hopkins, J.A. Cancelas, S.L. Teitelbaum, and D.A. Williams. 2005. Rac1 and Rac2 GTPases play distinct roles and are essential for full osteoclast differentiation. ASH Annual Meeting Abstracts 106: 67.
9. Manolagas, S.C., and R.S. Weinstein. 1999. New developments in the pathogenesis and treatment of steroid-induced osteoporosis. J Bone Miner Res 14: 1061-1066.
10. Prummel, M.F., W.M. Wiersinga, P. Lips, G.T. Sanders, and H.P. Sauerwein. 1991. The course of biochemical parameters of bone turnover during treatment with corticosteroids. J Clin Endocrinol Metab 72: 382-386.
11. Purpura, K.A., J.E. Aubin, and P.W. Zandstra. 2004. Sustained in vitro expansion of bone progenitors is cell density dependent. Stem Cells 22: 39-50.
12. Rickard, D.J., T.A. Sullivan, B.J. Shenker, P.S. Leboy, and I. Kazhdan. 1994. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161: 218-228.
13. Rubin, J., D.M. Biskobing, L. Jadhav, D. Fan, M.S. Nanes, S. Perkins, and X. Fan. 1998. Dexamethasone promotes expression of membrane-bound macrophage colony-stimulating factor in murine osteoblast-like cells. Endocrinol 139: 1006-1012.
14. Teitelbaum, S.L. 2000. Bone resorption by osteoclasts. Science 289: 1504-1508.
15. Weinstein, R.S. 2001. Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord 2: 65-73.
16. Weinstein, R.S., R.L. Jilka, A.M. Parfitt, and S.C. Manolagas. 1998. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. J Clin Invest 102: 274-282.
17. Weinstein, R.S., J.-R. Chen, C.C. Powers, S.A. Stewart, R.D. Landes, T. Bellido, R.L. Jilka, A.M. Parfitt, and S.C. Manolagas. 2002. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest 109: 1041-1048.